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WO/2000/004905A1 |
Benzo[$i(b)]quinolizidine and benzo[$i(f)]indolizidine derivatives are provided which are useful for the treatment of Alzheimer's disease, senile dementia, or other conditions characterized by memory loss. Pharmaceutical compositions con...
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WO/2000/004900A1 |
The present invention concerns antiviral compounds, their compositions, and use in the treatment of viral infections. More particularly, the invention provides benzimidazole derivatives for the treatment of respiratory syncytial virus in...
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WO/2000/003990A1 |
The invention concerns a pharmaceutical composition having an activity on the proliferation of clonogenic cells in tumours and comprising an efficient amount of a compound selected among the compounds of formulae (I) and (Ia) wherein: X,...
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WO/2000/004019A1 |
Described herein are compounds selective for a 5-HT¿1D? receptor, which have general formula (I) wherein: R?1¿ is selected from the group consisting of CR?5¿R?6¿CH¿2?NR?7¿R?8¿ and a group of formula (II) or (III) wherein R?2¿ is ...
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WO/2000/000487A1 |
The present invention relates to a compound of formula (I): or a pharmaceutical acid addition salt thereof; which is useful for activating 5-HT¿1F? receptors and inhibiting neuronal protein extravasation in a mammal.
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WO/1999/055704A1 |
The novel compounds of chemical formulae (I) and (II) exhibit $i(in vitro) antifungal activity against fungi including cutaneous filamentous fungus, such as $i(Epidermophyton, Microsporum, Trichophyton, Sporothrix schenckii, Aspergillus)...
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WO/1999/047521A1 |
The present invention concerns derivatives of general formula I (I' and I''), in which X represents a divalent radical of formula (a) or (b), R¿1?, R¿2?, R¿3?, and R¿4? represent, independently of each other, a hydrogen atom, a hydro...
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WO/1999/044987A1 |
Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are of general formula (I), where X¿1?, X¿2?, Y, and Z are defined variables. Such compounds and their pharmaceutically acceptable salts, multim...
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WO/1999/033828A1 |
The present invention refers to benzo[c]quinolizines derivatives, fully and partially saturated, having formula (I), and their pharmaceutically acceptable salts which proves useful for pharmaceutical and agricultural use being capable of...
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WO/1999/032480A1 |
Novel compounds having formulas (I), (II) or (III) or pharmaceutically-acceptable salts or prodrugs thereof, which are useful for controlling synaptic transmission; to therapeutically-effective pharmaceutical compositions of these compou...
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WO/1999/021855A1 |
Derivatives of pleuromutilin of formula (IA) or (IB) in which the glycolic ester moiety at position (14) is replaced by R?2¿(CH¿2?)¿m?X(CH¿2?)¿n?CH¿2?COO are of use in antimicrobial therapy. In which: each of n and m is independent...
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WO/1999/021856A1 |
The invention concerns 2-aminomethyl-benzo[a]quinolizidine derivatives, corresponding to general formula (I) in which: R¿1? represents either a hydrogen atom or a branched, linear or cyclic C¿1?-C¿4? alkyl group, a branched, linear or...
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WO/1999/011627A1 |
The invention relates to benzimidazole antibacterial compounds of formula (I) as described herein, pharmaceutical compositions containing the compounds, and methods for their production and use. These compounds are effective in inhibitin...
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WO/1999/007696A1 |
A quinolizine carboxylic acid derivative of formula (I) or a pharmaceutically acceptable salt thereof, wherein R?1¿ and R?2¿ have the same meanings as defined in the specification.
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WO/1999/005913A1 |
Described herein is the use of benzo[c]quinolizine derivatives of formula (I) as regulators of the growth of plants, and compositions for agricultural use containing the said derivatives or their salts.
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WO/1998/046570A1 |
This invention provides novel 5-HT�1F? agonists of Formula (I) in which X, Y, E, R, A, B, and n are as defined in the specification, which are useful for the treatment of migraine and associated disorders.
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WO/1998/042667A1 |
Compounds of general formula (1), tautomers, stereoisomers and optical isomers of them, and medicinally acceptable salts thereof, which exhibit excellent inhibitory activities against nNOS or iNOS, and therefore are useful as remedies fo...
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WO/1998/040383A1 |
This invention concerns compounds of formula (I), the pharmaceutically acceptable acid additions salts and the stereochemically isomeric forms thereof, wherein the dotted line represents an optional bond; X is oxygen or sulfur; -A- is a ...
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WO/1998/038191A1 |
A process for the preparation of a compound having formula (a) wherein R?1�, R?2�, R?3�, R?4�, and R?5� are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-...
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WO/1998/025930A2 |
The invention is concerned with the use of bi- and tricyclic pyridone compounds of general formula (I) and of their pharmaceutically acceptable salts for the production of medicaments for the prophylaxis or treatment of illnesses which a...
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WO/1998/022437A1 |
A process for the preparation of chiral 3-aminopyrrolidine of formula (I) and analogous bicyclic derivatives of formula (II) from dihydroxy olefins such as for the formula: HO-CH�2?-CH=CH-CH�2?-OAr by treatment with titanium isopropo...
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WO/1998/018783A1 |
Compounds represented by general formula (I) carrying a tricylic amine substituent optionally having various substituents, their salts, hydrates thereof or drugs containing these compounds as the active ingredient. Because of having favo...
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WO/1998/007695A1 |
The present invention relates to organic molecules capable of modulating, regulating and/or inhibiting protein kinase signal transduction. Such compounds are useful for the treatment of diseases related to unregulated protein kinase sign...
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WO/1998/005642A1 |
CFTR channel activator compounds from the benzo[c]quinolizinium family or families of compounds derived therefrom, as well as pharmaceutical compositions containing said compounds, and the uses thereof, particularly for treating cystic f...
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WO/1998/005659A1 |
Compounds of formula (3), and pharmaceutically acceptable salts and derivatives thereof, in which R?1� is vinyl or ethyl; and R?2� is a group R?3�, R?4�CH�2?-, or R?5�R?6�C=CH-; wherein each of R?3� and R?4� is an azabi...
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WO/1998/004937A1 |
The invention relates to photochromic compounds of general formula (I), in which: R1-R8 represent various substituents, characterized in that at least two of the groups R3-R6 are C1-C6 alkoxy groups.
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WO/1998/001443A1 |
A compound of formula (I), or a salt thereof, or a solvate thereof, wherein Ra represents a group R�5? which is hydrogen, alkyl or optionally substituted aryl and Rb represents a moiety of formula (a), wherein X represents a hydroxy or...
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WO/1997/044034A1 |
A remedy for rosacea being efficacious even against intractable rosacea which cannot be completely cured by using remedies comprising antibiotics such as minocycline and having a low toxicity, little side effects and a long-lasting drug ...
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WO/1997/040046A1 |
Benzoquinolizine derivatives represented by general formula (1), pharmaceutically acceptable salts thereof and medicinal compositions containing the same as the active ingredients, wherein R1 represents hydroxy or alkoxy; R2 represents h...
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WO/1997/030999A1 |
A compound of formula (I), wherein R1 represents a bicyclic structure in which a cycloalkyl or heterocyclo ring is bound to NH and is fused to a second ring selected from aryl or heteroaryl, and in which either or each ring is optionally...
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WO/1997/031000A1 |
A compound of formula (I) wherein n is an integer of up to 3; R1 represents cycloalkyl, aryl, heteroaryl or heterocyclo, any of which rings may be fused to a second ring selected from aryl, heteroaryl, to give a bicyclic structure, and i...
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WO/1997/030971A1 |
The present application describes m-amidino phenyl analogs of formula (I), wherein D can be amidino and E can be phenyl, which are useful as inhibitors of factor Xa.
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WO/1997/029106A1 |
The present invention provides protoberberine alkaloid derivatives useful as anticancer agents, and methods of use thereof. The invention also provides protoberberine derivatives useful as topoisomerase inhibitors. The invention further ...
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WO/1997/029107A1 |
The present invention refers to benzo[c]quinolizine derivatives of general formula (I), their pharmaceutically acceptable salts or esters, processes for their preparation and pharmaceutical compositions containing them.
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WO/1997/025309A1 |
Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and derivatives thereof, in which R1 is ethyl or vinyl, Y is a carbamoyloxy group, in which the N-atom is unsubstituted, or mono- or di-substituted, are useful...
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WO/1997/017344A1 |
There are provided novel compounds of formula (I), wherein X, R1, R2, R3, R4 and R5 are as defined in the specification and optical isomers and racemates thereof and pharmaceutically acceptable salts thereof; together with processes for ...
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WO/1996/039407A1 |
Antibacterial compounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, selected preferred examples of which include those compounds wherein A is =CR6-; R1 is cycloalkyl of from three to eight car...
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WO/1996/025932A1 |
A preventive/remedy for interstitial pneumonia, inflammatory intestinal diseases or vascular thickening which contains as the active ingredient quinolizinone compounds represented by general formula (I), salts thereof or hydrates thereof...
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WO/1996/022089A1 |
The present invention provides an antiproliferative p-heteroatom-substituted phenol compound having structure formula (I), wherein m is 0 to 3, n is 0 when Het is oxygen or sulfur, 0 to 4 when Het is nitrogen, Het is nitrogen, oxygen or ...
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WO/1996/013478A1 |
Novel retinoid-related compounds that can substitute for retinoic acid as preventives or remedies for various diseases and compounds that are antagonistic to retinoids, i.e., heterocyclic compounds represented by the general formula (1-I...
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WO/1995/026335A1 |
Novel n-arylaliphatic-n-alkyl-functionalised amides of formula (I), wherein Am is in particular a substituted piperidyl group. A method for preparing these compounds, and pharmaceutical compositions containing them are also disclosed. Th...
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WO/1995/010519A1 |
Antibacterical coumpounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, preferred examples of which include those coumpounds wherein R1 is cycloalkyl of from three to eight carbon atoms or subst...
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WO/1995/003302A1 |
Known and novel azabicyclic derivatives of formula (I) such as quinolizidines with calcium channel antagonist activity, in which: p, and q each independently represent an integer from 3 to 5; n is 0 to 6; m is 0 to 6; A is a bond, -CH=CH...
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WO/1994/024129A1 |
Compounds of formula (I), wherein R1 represents C1-4alkyl; and R2, R3, R4 and R5 each independently represent hydrogen, halogen, C1-4alkyl, C1-4alkoxy, C1-4alkoxyC1-4alkyl, C1-4alkylsulphonyl, trifluoromethylsulphonyl; optionally substit...
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WO/1994/019344A1 |
Compounds of formula X-NH-CO-Z and pharmaceutically acceptable salts thereof, and the use of a compound of said formula or a pharmaceutically salt thereof, wherein X is a monocyclic or polycyclic aromatic group, Z is of sub-formula (h), ...
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WO/1994/008994A1 |
Compounds of formula (I), wherein formula (I) consists of formulae (I-1) to (I-4), and pharmaceutically acceptable salts thereof, and the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof, and their use as ph...
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WO/1994/007863A1 |
Stereoisomeric substituted and/or unsubstituted octahydronaphthoquinolizines (OHNQs), and derivatives and analogs thereof are provided, including pharmaceutical and diagnostic compositions, as well as methods of making and using these co...
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WO/1993/023357A1 |
The present invention relates to stilbene derivatives which possess utility as anti-cancer agents. The compounds can be used to treat cancers which are susceptible to treatment therewith, and can be utilized in a method of treating such ...
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WO/1993/018027A1 |
Compounds of formula (I) and pharmaceutically acceptable salts thereof and their use as pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS disorders.
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WO/1993/016702A1 |
Quinobenzoxazine, quinobenzothiazines, and pyrido-acridine derivatives of formula (I) as well as the pharmaceutically acceptable salts, esters, amides and prodrugs thereof are disclosed, wherein R1 is hydrogen or acarboxy-protecting grou...
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