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WO/2012/098049A1 |
The present invention relates to a process for the preparation of statins by means of a Julia-Kocienski reaction between an aldehyde and a sulfone derivative in the presence of an alkaline metal alkoxy base. The resulting derivatives are...
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WO/2012/098050A1 |
The present invention relates to a process for the preparation of a 1-methyl-1H-tetrazole-5-thio derivative comprising reaction of a halomethyl substrate with 1-methyl-H-tetrazole-5-thiol to obtain a thio-ether compound, and oxidizing th...
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WO/2012/098048A1 |
The present invention relates to a process for the preparation of a diol sulfone derivative comprising reaction of a halomethyl substrate with a thio-aryl compound to obtain a thio-ether compound, and oxidizing the thio-ether compound to...
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WO/2011/162514A2 |
The present invention provides a novel method for preparing [1,2,3]-oxathiazolidine-2,2-dioxide or [1,2,5]-thiadiazolidine-1,1-dioxide derivatives. According to the manufacturing method of the present invention, it is possible to conveni...
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WO/2011/141848A1 |
Mineralocorticoid receptor antagonists (MRa), pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetic nephropathy and hypertension in mammals, including humans.
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WO/2011/073098A1 |
The invention relates to formula (I) or the salts thereof, in which the divalent groups X1, X2, X3, and X4 mean a group of the formulas CH, N, NH, O, or S, wherein the ring bonded to the 1-N atom of the pyrazol ring is a heteroaromatic f...
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WO/2011/067272A1 |
The present invention relates to compounds of formula (I): Wherein A1, A2, A3, A4, G1, L, Y1, Y2, Y3, Y4, R1, R2, R3 and R4 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to intermedia...
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WO/2011/060000A1 |
This disclosure concerns novel compounds of Formula (I) or as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A p...
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WO/2011/059784A1 |
Disclosed are compounds of Formula (I) or stereoisomers or salts thereof, wherein: X1, X2, X3, W, Q1, Q2, and G2 are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor ...
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WO/2011/039276A1 |
The invention relates to novel oxathiazinyl(het)arylsulfonylureas of the formula (I), to processes for preparation thereof and to the use thereof as crop protection agents and crop growth regulators, where J is J-1 to J-4, where J-1 to J...
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WO/2011/041655A1 |
Disclosed herein are novel quinazolin-4-amine derivatives that are inhibitors of Clk1, Clk2, Clk3, Clk4, or Dyrk1A. Also disclosed are quinazolin-4-amine derivatives as potent and selective inhibitors of Clk1, Clk4, and Dyrk1A. These age...
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WO/2011/023795A1 |
The present invention relates to (thio)morpholine derivatives of the formula (I), wherein R1 is selected from cyano, (2-4C)alkynyl, (1-4C)alkyl, (3-6C)cycloalkyl, (4-6C)cycloalkenyl, (6-8C)bicycloalkyl, (8-10C)bicyclic group, each option...
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WO/2011/012622A1 |
The present invention relates to benzoxazinone derivatives, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in treating disorders mediated by GlyT1, including neurological and...
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WO/2010/105048A9 |
The present invention relates to thiazolidinedione analogues that are useful for treating hypertension, diabetes, and inflammatory diseases. In other aspects, the present invention also presents methods of treating hypertension, diabetes...
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WO/2011/005028A2 |
Provided is a method for preparing (S)-5-chloro-N-((3-(4-(5,6-dihydro-4H-1,2,4-oxadiazin-3-yl)p
henyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide derivatives of Formula (I) which are useful as blood coagulation factor Xa inhibit...
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WO/2010/100144A1 |
The invention relates to compounds of formula (I) for the regulation of phosphoinositides 3-kinases activity and related diseases.
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WO/2010/090716A1 |
This invention provides compounds of formula (IA) or (IB): wherein R1, R2, G1 and HY are as described in the specification. The compounds are inhibitors of PI3K and/or mTor and are thus useful for treating proliferative, inflammatory, or...
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WO/2010/072310A1 |
The present invention relates to a novel benzoxathiazine derivatives of the formula (I), wherein R1, R2, R3, R4, R5 and R6 are as defined in the description, to a plurality of methods for the production thereof, and to the use thereof as...
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WO/2009/134224A1 |
Synergistic pesticidal mixtures are provided. The mixtures comprise a compound of formula (I) and at least a further pesticide.
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WO/2009/131977A1 |
Compounds comprising formula (I) or a pharmaceutically acceptable salt thereof, are disclosed, wherein J, B, Y, and A are as described in claims 1-13. Methods, compositions, and medicaments related thereto are also disclosed, for treatin...
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WO/2009/127726A1 |
Compounds of formula (I) in which the substituents are as defined in claim 1, are suitable for use as microbiocides.
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WO/2009/078498A1 |
A novel biarylpyrazole 4-carboxamide compound of formula (I) or a pharmaceutically acceptable salt thereof is effective as a cannabinoid CB1 receptor ligand, which is useful for preventing or treating obesity and obesity-related metaboli...
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WO/2009/046010A2 |
Monomethine dyes that have no or minimal fluorescence in buffer or in the presence of single stranded DNA or RNA, but strongly fluoresce in the presence of double-stranded DNA. In one embodiment, the dye is useful in quantitative RT-PCR.
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WO/2009/027393A2 |
The present invention relates to novel pyrazole compounds of the formulae (I) and (II), to their salts and their N-oxides which can be used for combating or controlling invertebrate pests, in particular arthropod pests. The invention als...
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WO/2009/020579A1 |
This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula Compounds of formula (I) include compounds of formulas (IA) and (IB). Also disclosed are methods of modulating gamma secretase...
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WO/2009/015776A1 |
The present application relates to novel substituted aryloxazole derivatives, a method for the production thereof, the use thereof for the treatment and/or prophylaxis of diseases and the use thereof for the production of drugs for the t...
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WO/2009/013348A2 |
The present invention concerns a compound of formula (I) or a salt, suitably a pharmaceutically acceptable salt, or solvate thereof, wherein the groups R1, R2, Ar', A and B are defined in the description, to compositions and use of the c...
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WO/2008/127275A2 |
Provided herein are compounds that modulate the activity of a bacterial peptidyl tRNA hydrolase, including compositions and dosage forms comprising the compounds. Further provided herein are methods for preventing or inhibiting bacterial...
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WO/2008/123207A1 |
[PROBLEMS] To provide a compound useful as a therapeutic agent for chronic renal failure or diabetic neuropathy. [MEANS FOR SOLVING PROBLEMS] Disclosed is an ornithine derivative having an EP4 receptor antagonistic activity. In the compo...
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WO/2008/124075A1 |
Disclosed are novel 2, 3 -benzodiazepine of formula (I), wherein R9 and R10 are alkoxy derivatives, methods of making the same, and their use in treating psychotic disorders. FIG. 1 shows, comparatively, the effect of clozapine, compound...
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WO/2008/116881A1 |
The object of the present invention is novel substituted pyrrolidine amides of the general formula (I) in which D, L, E, G, J, M, L1, L2 , R4 and R5 are defined as in the specification, the tautomers, enantiomers, diastereomers, mixtures...
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WO/2008/073956A2 |
The present invention is directed to cyclic sulfonamide derivatives of formula (I): or a pharmaceutically acceptable salt thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their u...
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WO/2008/064218A2 |
Disclosed are compounds, stereoisomers, tautomers, pharmaceutically acceptable salts, or prodrugs thereof of having Formula (I), their preparation, use, and compositions thereof for treating an infection mediated at least in part by a vi...
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WO/2008/050101A2 |
The invention relates to a novel group of compounds of Formula (I) or a salt thereof: wherein R1, A and HET-1 are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition med...
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WO/2008/044045A1 |
The invention provides combinations comprising (or consisting essentially of) one or more ancillary compound(s) and a compound of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 ...
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WO/2008/044027A2 |
The invention provides a compound for use in medicine, the compound being a compound of the formula (Vl0) or a salt, solvate, tautomer or N-oxide thereof: wherein the bicyclic group: is selected from the structures C1, C5 and C6: wherein...
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WO/2008/039023A1 |
A heteroaryl-pyrazole compound of formula (I) or a pharmaceutically acceptable salt thereof is effective as a cannabinoid CB1 receptor inverse agonist or antagonist, which is useful for preventing or treating obesity and obesity-related ...
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WO/2008/013414A1 |
This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1 )antagonist; and a pharmaceutical composition containing the same. The...
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WO/2008/005338A1 |
The present invention relates to certain biphenyl sulfonamide derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the histamine H3-receptor. Compounds and pharmaceutical compositions thereof ...
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WO/2007/137791A1 |
The invention relates to aryl-substituted heterocycles, methods for the production thereof, the use thereof for treating and/or preventing diseases, and the use thereof for producing medicaments used for treating and/or preventing diseas...
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WO/2007/137800A1 |
The invention relates to novel isoindolin-1-one-, isoindolin-3-one- and isoindolin-1,3-dione-derivatives, to methods for the production thereof, to the use thereof for treating and/or preventing diseases, and to the use thereof for produ...
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WO/2007/123853A2 |
Disclosed are compounds of Formula (1), including all geometric and stereoisomers, N-oxides, and salts thereof wherein G is O or NR3; U is C(=O), S(=O), C(=S), or S(O)2; Z is N or CR2; R1 is cyano; or C1-C6 alkyl, C2-C6 alkenyl, C2-C6 al...
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WO/2007/105637A1 |
Disclosed is a compound represented by the general formula (I), a salt or N-oxide of the compound, a solvate of the compound, salt or N-oxide, or a prodrug of the compound, salt, N-oxide or solvate, which can bind specifically to CCR5 an...
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WO/2007/092638A1 |
Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
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WO/2007/068374A2 |
The invention relates to novel thienylpyridyl carboxamides of formula (I) wherein R1, R8, R9, R10, R11 and A have the meanings cited in the description. The invention also relates to several methods for producing said substances, to the ...
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WO/2007/063010A1 |
The invention is concerned with novel vinylogous acids derivatives of formula (I) wherein A and R1 to R6 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit ch...
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WO/2007/060541A2 |
The use of a compound of formula (I) wherein Y is a single bond, C=O, C=S or S(O)mwhere m is 0, 1 or 2; the ring is a 6-membered aromatic or is a 5 or 6 membered heteroaromatic ring; Ra, R1, R2, R4 and R8 are specified organic groups; n ...
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WO/2007/059359A2 |
The invention is related to compounds of formula (I) as antagonists of the TGFβ family type I receptors, Alk5 and/or AIk 4, compositions and methods of use. The compounds of formula (I) can be employed in the prevention and/or treatment...
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WO/2007/057407A2 |
The invention relates to insecticidal methods using 3-amino-1,2-benzoisothiazole compounds of the formula (I) wherein the variables n and R1 to R6 are as defined in the description. The invention relates to methods of combating or contro...
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WO/2007/053135A1 |
The present application discloses methods of detecting and treating cancer which express MUC1 aberrantly.
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