Heterocyclic Compounds

Matches 301 - 350 out of 30,874	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/2023/239189A1	NOVEL COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING SAME The present invention provides a novel compound and an organic light emitting device using same.
WO/2023/239629A1	COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THAT DEGRADE CDK2 This disclosure provides compounds and pharmaceutically acceptable salts thereof that are useful as modulators of targeted ubiquitination. The compounds disclosed herein bind to and degrade one or more cyclin dependent kinases 2 (CDK2).
WO/2023/237504A1	HSD17B13 INHIBITORS The present invention encompasses heteroaryl substituted 2,6-difluorophenol compounds of formula (I), wherein the groups A1 to A3, and Z have the meanings given in the claims and specification, their use in pharmaceutical compositions wh...
WO/2023/239710A1	BENZOPYRIMIDIN-4(3H)-ONES AS PI3K INHIBITORS Novel PI3K inhibitors of the general Formula (1) are described along with methods of their preparation and their use in the treatment of diseases associated with the elevation or activation of the PI3K pathway, wherein R1 to R8 are as de...
WO/2023/235925A1	COMPOUNDS WITH MERTK ACTIVITY The present invention provides compounds of Formula (I), which have activity as inhibitors of MERTK. The present invention also provides radio-labelled compounds which may be used in diagnostic and imaging compositions. The present inven...
WO/2023/239729A1	PYRIDINAMINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS The present disclosure is directed to compounds of Formula (I): wherein m, n, Y, R1, R2, R3, R4 and R5 are each as described herein, as stereoisomers, enantiomers or tautomers thereof or mixtures thereof; or pharmaceutically acceptable s...
WO/2023/237116A1	PROTEIN DEGRADERS AND USES THEREOF The present invention discloses a protein degrader such as a GSPT1 degrader and use thereof, particularly use in the prevention and/or treatment of diseases.
WO/2023/231795A1	HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING ELEMENT COMPRISING SAME The present invention relates to the technical field of organic electroluminescent materials, and particularly relates to a heterocyclic compound and the use thereof. The structural formula of the compound is as shown in formula (I). The...
WO/2023/232133A1	COMPOUND FOR INHIBITING OR DEGRADING BCL6 AND USE THEREOF IN PHARMACEUTICS The present invention relates to a compound represented by general formula (I) or a stereoisomer, a deuterated form, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt or an eutectic thereof, and an intermediate and a...
WO/2023/231948A1	ISR INHIBITORS, METHOD FOR PREPARING SAME, AND USE THEREOF Disclosed are a class of ISR inhibitors, a method for preparing same, and use thereof. The present invention belongs to the technical field of biopharmaceutics. The compound of the present invention is a compound having a structure of fo...
WO/2023/235384A1	COMPOUNDS FOR ENHANCING READ THROUGH OF GENES CONTAINING PREMATURE TERMINATION CODONS AND METHODS FOR MAKING AND USING THE SAME Disclosed herein are new aromatic compounds, compositions that include one or more aromatic compounds, and methods of synthesizing the same. Also disclosed herein are methods of enhancing readthrough of genes containing premature termina...
WO/2023/234425A1	AMINO ACID ACTIVE ESTER AND SALT THEREOF The present invention provides a novel active ester of an amino acid to be used for amino acylation of tRNA, said ester being capable of reducing risks to safety and waste. The present invention provides a compound represented by formula...
WO/2023/227734A1	FLAVIVIRUS INHIBITORS The invention relates to compounds that are inhibitors of Flavivirus NS2B-NS3 proteases and inhibit replication of flavivirus in cells. Compounds of this invention are useful alone or in combination with other agents for use in the treat...
WO/2023/227696A1	NEW DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS The invention relates to compounds that are useful for the prevention or treatment of TRPM3 mediated disorders, more in particular disorders selected from pain, epilepsy and inflammatory hypersensitivity. The invention also relates to a ...
WO/2022/226191A9	METHODS OF STABILIZING THE NEURONAL PROTEOME AGAINST COLLAPSE AND PROTECTING VASCULAR CELLS The disclosure provides method of enhancing neuronal, vascular cell, and macrophage proteostasis, in a subject by administering a CMA activator to the subject. Enhancing proteostasis is a method of preventing or slowing advancement of an...
WO/2023/227697A1	NEW DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS The invention relates to compounds that are useful for the prevention or treatment of TRPM3 mediated disorders, more in particular disorders selected from pain, epilepsy and inflammatory hypersensitivity. The invention also relates to a ...
WO/2023/226658A1	NITROGEN-CONTAINING FIVE-MEMBERED HETEROCYCLIC DERIVATIVES AS CHECKPOINT KINASE 1 INHIBITOR AND USES THEREOF The present disclosure relates generally to nitrogen-containing five-membered heterocyclic derivatives usefulness in treatment of conditions associated with Checkpoint kinase (CHK), particularly more specifically CHK-1 enzymes. Methods o...
WO/2023/229375A1	HETEROCYCLIC COMPOUND AS DIACYLGLYCEROL KINASE INHIBITOR AND USE THEREOF The present invention relates to a heterocyclic compound represented by chemical formula 1, exhibiting a diacylglycerol kinase inhibitor activity, a pharmaceutical composition comprising same as an active ingredient, and use thereof.
WO/2023/226323A1	QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF The present invention relates to the technical field of chemical medicine, and in particular to a quinazoline derivative, and a preparation method therefor and the use thereof. The quinazoline derivative provided by the present invention...
WO/2023/220831A1	HETEROARENES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME Disclosed are compounds and pharmaceutically acceptable salts thereof that may be used in the treatment of subjects in need thereof. The compounds disclosed herein may be inhibitors of tyrosine and threonine-specific cdc2-inhibitory kina...
WO/2023/222115A1	HYDROXYAMIDE DERIVATIVE AND USE THEREOF Provided in the present application is a hydroxyamide derivative represented by formula (I), and a tautomer, stereoisomer, solvate, metabolite, isotopically-labeled compound, pharmaceutically acceptable salt or co-crystal thereof. The co...
WO/2023/223174A1	COMPOSITIONS FOR PREVENTING OR TREATING IDIOPATHIC PULMONARY FIBROSIS (IPF) The present disclosure relates to a pharmaceutical composition for preventing or treating idiopathic pulmonary fibrosis, comprising a compound represented by formula I, optical isomers thereof or pharmaceutically acceptable salts thereof...
WO/2023/221868A1	DERIVATIVE OF ISOXAZOLINE COMPOUND AND USE THEREOF Provided in the present invention are a derivative of an isoxazoline compound and the use thereof in the prevention and treatment of parasitic infections. The derivative of the isoxazoline compound has the following general structural fo...
WO/2023/222137A1	NOVEL TETRAHYDROISOQUINOLINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAID COMPOUND, AND USE THEREOF Provided are a novel tetrahydroisoquinoline compound, a preparation method therefor, a pharmaceutical composition containing said compound, and a use thereof. Specifically, provided are a nitrogen-containing heterocyclic compound as repr...
WO/2023/222849A1	AMINO HETEROAROMATIC COMPOUNDS USEFUL IN THE TREATMENT OF LIVER DISEASES The specification relates to compounds of Formula (I) and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in the tre...
WO/2023/222084A1	BENZIMIDAZOLE OR AZABENZIMIDAZOLE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF Disclosed in the present invention are a benzimidazole or azabenzimidazole compound, a preparation method therefor and a use thereof. The benzimidazole or azabenzimidazole compound has a structure shown in formula (I). A use of the compo...
WO/2023/224981A1	HSD17B13 INHIBITORS AND USES THEREOF Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such...
WO/2023/225244A1	HETEROCYCLIC COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE The present disclosure provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof and its use in, e.g. treating a condition, disease, or disorder in which lowering mutant huntingtin protein ("mHTT") in a subject is ...
WO/2023/222850A1	AMIDO HETEROAROMATIC COMPOUNDS USEFUL IN THE TREATMENT OF LIVER DISEASES The specification relates to compounds of Formula (I): and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in the tr...
WO/2023/217851A1	PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF-κB INDUCING KINASE The present disclosure relates to compounds of Formula (I') that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are useful for preventi...
WO/2023/218241A1	HETEROARYL DERIVATIVE COMPOUNDS, AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF The present invention relates to a heteroaryl derivative compound and a pharmaceutical composition comprising thereof. Specifically, the present invention relates to a heteroaryl derivative compounds having RAF inhibitory activity.
WO/2023/220404A1	TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS Provided herein are methods and compositions for treating non-alcoholic steatohepatitis (NASH) in a patient in need thereof, wherein the NASH of the patient is characterized by advanced stage hepatic fibrosis. The methods comprise admini...
WO/2023/220129A1	BENZOYPARAZINE PYRAZINES ANE THEIR USES The present disclosure features compounds of Formula I, Formula I, or pharmaceutically acceptable salts thereof, and formulations containing the same. Methods of treating BAF complex-related disorders, such as cancer, are also disclosed.
WO/2023/220225A1	INHIBITORS OF HUMAN RESPIRATORY SYNCYTIAL VIRUS AND METAPNEUMOVIRUS The present disclosure is directed to compounds of Formula (I) or a pharmaceutically acceptable salt thereof, and their use for the treatment of hRSV and hMPV.
WO/2023/217879A1	PYRROLIDIONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE The present disclosure relates to compounds of Formula (I) that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are useful for preventin...
WO/2022/212568A9	COMPOUNDS AND COMPOSITIONS FOR MODULATING LIPID METABOLISM The present disclosure features methods and related compositions that, inter alia, modulate the mitochondrial lipid shunt pathway, including the modulating the cellular mechanisms by which lipids (e.g., fatty acids) are transported betwe...
WO/2023/218245A1	HETEROARYL DERIVATIVE COMPOUNDS, AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF The present invention relates to heteroaryl derivative compounds and a pharmaceutical composition comprising thereof. Specifically, the present invention relates to heteroaryl derivative compounds having RAF inhibitory activity.
WO/2023/218023A1	THIAZOLOARYL-METHYL SUBSTITUTED CYCLIC HYDRAZINE-N-CARBOXAMIDE DERIVATIVES The present invention relates to compounds of the formula (I) Formula (I) wherein Ar1, R1, R2, R3, X1, X2, Y, and Z are as described in the description, to their preparation, to pharmaceutically 5 acceptable salts thereof, and to their u...
WO/2023/217276A1	HETEROCYCLIC SUBSTITUTED AROMATIC COMPOUND, PREPARATION METHOD THEREFOR, HERBICIDAL COMPOSITION AND APPLICATION The present invention belongs to the technical field of pesticides, and specifically relates to a heterocyclic substituted aromatic compound, a preparation method therefor, a herbicidal composition and an application. The compound is as ...
WO/2023/218201A1	IKK INHIBITORS The present invention relates to IKK-alpha inhibitory compounds, or a pharmaceutically acceptable salts, hydrates or solvates thereof, having the structural Formula (I), shown below: (I) wherein R1, X, R3 R4 and X1 are each as defined he...
WO/2023/217232A1	KINESIN KIF18A INHIBITOR AND USE THEREOF Provided are a kinesin KIF18A inhibitor represented by formula (I) and use thereof. The compound can regulate KIF18A protein to influence the cell cycle and the cell proliferation process, so as to treat cancers and cancer-related diseas...
WO/2023/218194A1	NUCLEIC ACID BINDERS The present invention concerns compounds suitable as RNA or DNA binders. RNA or DNA binders are useful in the treatment of various conditions, including those caused by microbial infection and cancer. The present invention concerns speci...
WO/2023/217018A1	EZH2 INHIBITOR AND USE THEREOF IN MEDICINE Provided is a compound having a structure of formula (I), which has cancer treatment activity. Further provided are a preparation method for the compound of formula (I), and a pharmaceutical composition comprising the compound.
WO/2023/217906A1	PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE The present disclosure relates to compounds of Formula (I) that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are useful for preventin...
WO/2023/217275A1	HETEROCYCLE-SUBSTITUTED AROMATIC COMPOUND, METHOD FOR PREPARING SAME, HERBICIDAL COMPOSITION, AND USE THEREOF The present invention belongs to the technical field of pesticides, and particularly, relates to a heterocycle-substituted aromatic compound, a method for preparing same, a herbicidal composition, and use thereof. The compound is represe...
WO/2023/218203A1	DIHYDROINDENE DERIVATIVES AS MALT1 INHIBITORS The present invention relates to compounds that are MALT1 inhibitors. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical c...
WO/2023/220741A1	ALPHA 4 BETA 7 INTEGRIN MODULATORS AND USES THEREOF The present disclosure provides small molecule compounds and pharmaceutical compositions for the modulation of alpha 4 beta 7 integrin, useful for the treatment of inflammatory conditions such as inflammatory bowel disease, including ulc...
WO/2023/217063A1	BENZO[D]ISOXAZOLE COMPOUND AND USE THEREOF The present application provides a benzo[d]isoxazole compound and use thereof. The compound has a structure represented by the following formula I. The benzo[d]isoxazole compound of the present application can induce the degradation of B...
WO/2023/216992A1	CYANINE-TREHALOSE COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF Provided are a cyanine-trehalose compound, a method for preparing same, and use thereof. Specifically, the compound is represented by formula I. The cyanine-trehalose compound can be used for detecting Mycobacterium tuberculosis, and fea...
WO/2023/213308A1	AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF The present invention provides an amide-substituted heterocyclic compound or an isomer, a solvate, a deuterated derivative or a pharmaceutically acceptable salt of the compound, wherein R1, R2, R3, R4, Ⓐ, L, L1, X, X1, and Y1 are defin...

Matches 301 - 350 out of 30,874	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >