Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 401 - 450 out of 5,698

Document Document Title
WO/2020/033520A1
The present invention provides compounds of Formula (I) useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders, wherein each of Ring A, L, Q, R1, R2, R3, R4, R7, and R8 along with other variabl...  
WO/2020/031107A1
The invention is directed to substituted tetrahydrofuran derivatives. Specifically, the invention is directed to compounds according to Formula (I), wherein C, D, L1, L2, R1, R2, R3, R4, R5, R6, Y1, Y2, z1, z2, z3, z4, X1, X2, X3, X4, X5...  
WO/2020/026054A1
The compositions and compounds of formula I and formula II which includes nucleic acid synthesis inhibitor conjugates or its polymorphs, enantiomers, stereoisomers, solvates, and hydrates thereof. These conjugates may be formulated as ph...  
WO/2020/025030A1
Provided are an aromatic compound having immunoregulatory effect, a preparation method thereof, and a use of the same in regulating immune responses or inhibiting PD-1/PD-L1.  
WO/2020/021953A1
Provided is a composition for optical materials that gives optical materials which can have at least one improved property selected from among satisfactory mold releasability after polymerization and curing, unsusceptibility to separatio...  
WO/2020/021113A1
The invention relates to a process to prepare a compound of the following formula (I): (I), in which P represents a protective group of a hydroxyl function which is a -COR1 group with R1 representing an aryl or a (C1C6)alkyl, R represent...  
WO/2020/015675A1
The present invention belongs to the technical field of semiconductors. Disclosed are a compound having triarylamine as a core and an application thereof. The structure of the compound provided in the present invention is represented by ...  
WO/2020/008382A1
The present application relate to a process for preparation of 4-methylene tetrahydrofuran compound of formula II, which is useful as an intermediate for the preparation of halichondrin B analogues such as eribulin and its pharmaceutical...  
WO/2020/006294A1
Disclosed herein are methods of treating liver fibrosis by administering calpain inhibitors to subjects in need thereof.  
WO/2019/242691A1
Provided are a paclitaxel-lipid-polysaccharide dual-type conjugate related to general formula I, a preparation method therefor, a use thereof, and a pharmaceutical composition comprising same. The present invention also relates to a seri...  
WO/2019/245910A1
The present invention relates to triazine compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating autoimmune, inflammatory, and neurodegenerative diseases by adminis...  
WO/2019/242687A1
The present invention discloses a 1,3-dioxane-4,6-dione compound, and a preparation method, a pharmaceutical composition, and an application thereof. The structure of the compound is represented by formula I, and the definition of each s...  
WO/2019/245169A1
According to various embodiments of the present invention, a method of producing bifunctional furan epoxy (BFFE) can produce BFFE by using bio-based monofunctional furan raw material, the method comprising the steps of: conducting a reac...  
WO/2019/233440A1
Disclosed are compounds for the treatment or prevention of liver diseases, which are compounds represented by the general formula (I) or (II), optical isomers or pharmaceutically acceptable salts thereof that can be applied to the prepar...  
WO/2019/229464A1
There are described compounds of formula (I): (I) and their use as a medicament in the treatment of diseases associated with the abnormal or elevated catabolism of tryptophan, such as, cancer, immunosuppression, viral infection, depressi...  
WO/2019/232275A1
Compounds that inhibit mitogen-activated protein kinases (MAPKs) are disclosed. Some inhibitor compounds specifically target a single MAPK such as MAPK13, while others target multiple MAPKs such as MAPK13 and MAPK12. The compounds can be...  
WO/2019/224373A1
The present invention relates to the use of 2-furyl-and 2-thienyl-substituted di-and tetrahydropyrans of the formula (I) wherein the variables are as defined in the claims and the description, as aroma chemicals;to aroma chemical composi...  
WO/2019/190409A9
There is provided a compound represented by general formula (lb), wherein ring A is a carbocyclic or heterocyclic ring, a reaction product of the reaction between one or more said compounds and one or more amine containing compounds. Als...  
WO/2019/222157A1
Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and...  
WO/2019/215633A1
The present invention is directed to 5,5-difluoro- and 5-fluoro-5-methyl-C-glycoside derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by SGLT activity, more par...  
WO/2019/199667A2
The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, pa...  
WO/2019/193062A1
The invention discloses compounds of Formula (I) wherein R1, R2, R3, R3A, R4, and R5 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharm...  
WO/2019/192912A1
There is provided a synthesis of [18F]SFB (N-succinimidyl 4-[18F]fluorobenzoate) using a one-step reaction procedure without generating radioactive waste gases. [18F]SFB is useful as a reagent for labeling of low- and high-molecular weig...  
WO/2019/190999A1
Disclosed herein are methods of treating fibrotic disorders by administering compounds selective for CAPN1, CAPN2, and/or CAPN9 such that side effects, off pathway interactions, and/or toxicities are minimized. Such methods may, for exam...  
WO/2019/185875A1
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as pesticides, especially as herbicides.  
WO/2019/175713A1
The present invention relates to the new catechol molecules and their use as inhibitors to P450 related metabolic pathways. The invention further relates to a method of controlling crop pests and/ or non-crop pests that are resistant to ...  
WO/2019/178119A1
Disclosed are aminocoumarin compounds, pharmaceutical compositions containing aminocoumarin compounds, and methods of their use, e.g., in the treatment of a Gram- negative bacterial infection.  
WO/2019/171278A1
The present invention is directed to heterocycloalkenyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the GPR120 and / or GPR40 receptors. 5 More particul...  
WO/2019/170543A1
The present invention covers heterocyclic compounds of general formula (I) in which T, U, Y, Z, R1 and R3 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceuti...  
WO/2019/166003A1
The present invention belongs to the technical field of medicine, and discloses use of 14-deoxy-11,12-dehydro-8,12-epoxy-andrographolide and derivatives thereof and 14-deoxy-11,12-dehydro-7,8-ene andrographolide and 15-substituted deriva...  
WO/2019/168170A1
The purpose of the present invention is to provide a compound having high binding specificity for amyloid proteins and high blood-brain barrier permeability, and featuring rapid elimination from normal tissues. The present invention rela...  
WO/2019/162458A1
The present invention relates to novel compounds which are particularly useful as inhibitors of bacterial glutaminyl cyclases (bacQC); pharmaceutical compositions comprising such compounds; compounds and/or pharmaceutical compositions fo...  
WO/2019/162323A1
The present invention encompasses compounds of formula (I) (I), wherein the groups R1 to R5 have the meanings given in the claims and specification, their use as inhibitors of mutant EGFR, pharmaceutical compositions which contain compou...  
WO/2019/161010A1
The present invention relates to polycyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 to R4, R7 to R10, Y and A are as defined herein. The invention also relates to pharmaceutical compositions com...  
WO/2019/160315A1
The present invention relates to a heterocyclic compound of formula 1 and an organic light emitting device comprising the same.  
WO/2019/161157A1
Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with histone acetyltransferase (HAT).  
WO/2019/156903A1
Disclosed are compounds of Formula 1, wherein J is and R1a, R1b, R2, R3, R4, R5, R6, R7, R8, R14, R15, R16, Q and X are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for c...  
WO/2019/154663A1
The present invention relates to the use of compounds of formula I, wherein the variables are defined as given in the description and claims. The invention further relates to the compounds I and composition for compounds of formula I.  
WO/2019/150305A1
Compounds of the general formula (I): processes for the preparation of these compounds, compositions containing these compounds, and compounds (I) for use as inhibitors of the KRAS protein for the tretament of cancer.  
WO/2019/145719A1
The present invention relates to compounds of Formula I as defined herein, and salts and solvates thereof. (I) The present invention also relates to pharmaceutical compositions comprising compounds of Formula (I), and to compounds of For...  
WO/2019/138332A1
Process for the preparation of a disubstituted diaryloxybenzoheterodiazole compound having general formula (I).  
WO/2019/134667A1
A compound as an SGLT1/SGLT2 dual inhibitor, and an application thereof in the preparation of a drug as the SGLT1/SGLT2 dual inhibitor. The compound is a compound represented by formula (I), an isomer thereof, or a pharmaceutically accep...  
WO/2019/121691A1
The present disclosure relates to compounds of Formula (I): (I) and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for...  
WO/2019/126505A1
This application relates to compounds of Formula (I) or pharmaceutically acceptable salts thereof, which are inhibitors of ΡΙ3Κ-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular dis...  
WO/2019/121159A1
The present invention relates to the compounds of formula (I), and the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof wherein the variables are defined according to the description, formula...  
WO/2019/121373A1
The present invention relates to the pyrimidine compounds of formula (I), or their agriculturally acceptable salts or derivatives as herbicides, wherein the variables are defined according to the description, use of pyrimidine compounds ...  
WO/2019/124903A1
An organic light emitting device comprising a compound represented by formula 1 as a light emitting auxiliary layer material and an electronic device comprising the same are disclosed. As the compound represented by formula 1 is comprise...  
WO/2019/122345A1
The present invention relates to benzamide compounds of formula I wherein the variables are defined as in the claims and the description, the N-oxides and salts thereof,and to compositions comprising the same. The invention also relates ...  
WO/2019/113693A1
Compounds that are inhibitors of retinoic acid inducible P450 (CYP26) enzymes. The compounds have retinoid activity, are resistant to CYP26-mediated catabolism, act as inhibitors of CYP26B1, and are used for treating diseases that are re...  
WO/2019/101719A1
The present invention relates to triarylamine compounds according to a defined formula. The present invention further relates to methods for producing said compounds, to the use of the compounds in electronic devices, and to electronic d...  

Matches 401 - 450 out of 5,698