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JPH09503994A |
A novel class of therapeutic compounds, denominated Balanoids, is disclosed. Balanoids have protein kinase C inhibitory activity and selectivity among the isoforms of protein kinase C. Balanoids are useful for treatment of diseases relat...
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JPH0940662A |
To obtain a tricyclic compound having antagonisms to substance P and bradykinin, and useful for curing and prevention of allergy, asthma, inflammation, pain relief, autoimmune disease, shock, etc. This compound is expressed by formula I ...
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JP2577189B2 |
PURPOSE: To obtain a new hydrazine derivative exhibiting a high insecticidal activity against insect pests with resistance to inssectide, especially Hemiptera insect pests. CONSTITUTION: A compound of formula I[A, B are O, S, CO, group o...
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JP2577154B2 |
PURPOSE: To provide a new compound useful as an insecticide for paddy field, plowed land, orchard, forest and environmental hygienic treatment, exhibiting especially excellent activity on lepidopterous vermin and having low toxicity. CON...
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JPH0920755A |
To obtain the subject compound having an α1 receptor antagonistic action and a bladder reflex suppressing action characteristic of prostate and useful as a treating agent for dysuria accompanying to prostate hyperplasia and a treating a...
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JPH08301763A |
PURPOSE: To obtain a composition consisting of a powdery inorganic carrier with both sparingly water-soluble medicinal substance and nonionic surfactant adsorbed thereto, capable of quickly releasing the medicinal substance through solub...
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JP2549997B2 |
PURPOSE: To obtain the subject new compound useful as a raw material compound for dibenzothiepin derivatives useful as highly safe anti-inflammatory agents having excellent anti-inflammatory and analgesic activities. CONSTITUTION: This h...
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JP2549239B2 |
PURPOSE: To obtain a new heterocyclic compd. or a salt of its carboxylic acid useful as a therapeutic agent for an autoimmune disease or a disease having a strong immunological component, in particular psoriasis. CONSTITUTION: This heter...
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JP2544123B2 |
Compounds represented by general formula (I), (wherein Y-Z represents (II), -CH=CH- or -CH2CH2-, R1 and R2 each represents a substituent, R3 represents hydrogen, alkyl or alkoxy, R4 represents hydrogen, alkyl, optionally substituted alke...
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JPH08259558A |
PURPOSE: To obtain a new 2-amino-1-phenylethanol compound, having excellent depressomotor actions on an enteric canal and useful for treating or preventing diseases in a gastrointestial tract accompanying an abnormal tension of human and...
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JPH08253472A |
PURPOSE: To obtain a dibenzothiepin derivative by subjecting a thiepinone as a starting raw material to Friedel-Crafts reaction, treating the reaction product with an alcoholate and a sulfonyl compound and subjecting the resultant substa...
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JP2526005B2 |
PURPOSE: To obtain a new compound useful as a therapeutic agent for hypertension, congestive heart failure, renal failure, glaucoma, etc. CONSTITUTION: This compound is expressed by formula I {R1 is H, halogen or lower alkyl; A is cyano,...
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JPH08501771A |
Disclosed are a novel class of anti-androgenic compounds including saturated and unsaturated fatty acids, their derivatives, and synthetic analogs, according to the following formula: CH3-(CH2)a-(CR1R2CH=CH)b-(CH2)c-COOH, wherein R1 and ...
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JPH07103115B2 |
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JPH07100688B2 |
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JPH0798817B2 |
The invention concerns:Novel dibenz/b,e/oxepin and dibenz/b,e/thiepin compounds having the general formula:wherein X is 0 or S,R1, R2, R3 and R4 are the same or different and are each selected from the group consisting of hydrogen, lower...
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JPH07252250A |
PURPOSE: To obtain a new 10-membered ring enynallene compound having a short and ready synthesis process, a highly simplified structure and extremely high DNA chain cutting activity. CONSTITUTION: This compound is expressed by formula I ...
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JPH0786094B2 |
Compounds of the formula in which the symbols R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, n, X and Y have the meaning indicated in the description, can be used as medicines for oncological and dermatological indications.
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JPH0764840B2 |
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JPH0751574B2 |
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JPH07504887A |
The present invention relates to novel tocotrienols and tocotrienol-like compounds displaying biological activity. The tocotrienols and tocotrienol-like compounds of this invention may be conveniently obtained from biological sources or ...
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JPH07138212A |
PURPOSE: To obtain a new aminoanthraquinone compound useful as an anti- tumor agent having reduced toxicity while retaining strong anti-tumor activity. CONSTITUTION: A compound of formula I [R1 is H, a lower alkyl or a lower alkoxy; R2 i...
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JPH07109273A |
PURPOSE: To efficiently obtain the compound useful as an intermediate for medicines, agricultural chemicals, etc., in a high yield substantially without causing the environmental pollution by reacting a specific arylthiomethylbenzoic aci...
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JPH0735357B2 |
A muscarinic receptor antagonist, useful in treating irritable bowel syndrome, of the formula:- or a pharmaceutically acceptable salt thereof, wherein R<1> is a group of the formula:- where Z and Z<1> are each independently hydrogen, hal...
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JPH0710832B2 |
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JPH0694464B2 |
Disclosed is a tricyclic compound represented by the formula (I): wherein each of R<1>, R<2>, R<3> and R<4> independently represents hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, amino, C1-6 alkylamino, halogenated C1-6 alkyl, halog...
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JPH0688995B2 |
NEW MATERIAL:A compound of formula I (R<1>, R<2> are H, halogen, CF3, hydroxyl, NH2, nitro, cyano, 1-4 C alkyl, 1-4C alkoxy, 2-5C alkanoylamino; n is 0, 1, 2; formula II is single or double bond). EXAMPLE:5-Oxo-2,3,4,5-tetrahydro-1-benzo...
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JPH06507616A |
The invention relates to therapeutically active azaheterocyclic compounds and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating a central nervous system ailment related to the GABA uptake.
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JPH06206858A |
PURPOSE: To provide a tricyclic compound having an acylcoenzyme A: cholesterol-acyltransferase-inhibiting action and useful as a therapeutic medicine for hyperlipemia and arterial sclerosis. CONSTITUTION: The tricyclic compound of formul...
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JPH0653716B2 |
A compound of the formula (IA) or (IB), useful in treating diseases associated with the altered motility and/or tone of smooth muscle, such as irritable bowel syndrome, of the formula:- and their pharmaceutically-acceptable salts, where ...
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JPH0651697B2 |
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JPH0649668B2 |
A compound for use in lowering blood cholesterol having the relative stereochemical formula:- wherein R is hydrogen, (C1-C3)alkyl, phenyl, benzyl or a conventional radical forming an ester group which is hydrolyzable under physiological ...
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JPH0645600B2 |
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JPH06503072A |
(57) [Summary] Since this publication is application data before electronic filing, summary data is not recorded.
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JPH0615538B2 |
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JPH05339223A |
PURPOSE: To provide a novel tricyclic compound having an acylcoenzyme A: cholesterol-acyltransferase-inhibiting action and useful as a hyperlipidemia therapeutic agent and an arterial sclerosis therapeutic agent. CONSTITUTION: A tricycli...
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JPH0584316B2 |
A benzofuran derivative having the general formula (I):whereinR' is hydrogen atom, a benzyl group, unsubstituted or substituted with a halogen atom or an alkyloxy group, or an alkyl group having 1 to 3 carbon atoms, R2 is hydrogen atom o...
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JPH05286963A |
PURPOSE: To provide the novel compound having a remarkable action for inhibiting the collagen-inducing platelet aggregation. CONSTITUTION: A compound of formula I (R1 is H, lower alkyl; R2 is lower alkyl; Z is O, S, e.g. 1,2,4,5-tetrahyd...
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JPH0572902B2 |
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JPH05239024A |
PURPOSE: To provide a new condensed heterocyclic carboxylic acid derivative having excellent cholinesterase inhibiting action and useful as an agent for the treatment and prevention of geriatric dementia. CONSTITUTION: The compound of fo...
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JPH0555509B2 |
NEW MATERIAL:The compound of formula I (R<1> and R<2> are H, halogen, trifluoromethyl, OH, amino, nitro, 1-4C alkyl, etc.; R<2> is H, 1-8C alkyl, hydroxy-1-4C alkyl, 2-5C alkanoyloxy-1-4C alkyl, aryl, aryl-1-4C alkyl, etc.; n is 0-2; dot...
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JPH0482129B2 |
This invention relates to bicyclic catechol derivatives having the general formulae I and II I II wherein R1, R2, R3 and Z represent various substituents, to a preparation process of the same comprising reacting a compound of formula III...
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JPH0469152B2 |
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JPH04506205A |
PCT No. PCT/SE90/00179 Sec. 371 Date Nov. 25, 1991 Sec. 102(e) Date Nov. 25, 1991 PCT Filed Mar. 20, 1990 PCT Pub. No. WO90/11303 PCT Pub. Date Oct. 4, 1990.Initiators for cationic polymerization by thermal activation, photochemical acti...
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JPH04202153A |
NEW MATERIAL:A tricyclic compound shown by formula I [R1 to R3 are lower alkyl or R1 and R2 or R2 and R3 are bonded to together form lower alkylene; Z is O, S, NR4 (R4 is lower alkyl), carbonyl or CHOR5 (R5 is H or lower alkyl); (n) is 1...
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JPH0443050B2 |
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JPH0419233B2 |
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JPH0417956B2 |
This invention relates to bicyclic catechol derivatives having the general formulae I and II I II wherein R1, R2, R3 and Z represent various substituents, to a preparation process of the same comprising reacting a compound of formula III...
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JPH0358341B2 |
PCT No. PCT/JP85/00445 Sec. 371 Date Apr. 10, 1986 Sec. 102(e) Date Apr. 10, 1986 PCT Filed Aug. 9, 1985 PCT Pub. No. WO86/01203 PCT Pub. Date Feb. 27, 1986.Compounds of the formula: wherein A means an alkylene; Y-Z means -CH=CH-, -CH2CH...
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JPH0341022A |
PURPOSE: To obtain a treating agent of hyperuricemia having low side effects specific to psychotropic agents, such as suppressive action on nervous system, comprising a dibenzothiepin (or debenzoxepin) derivative, which is novel except a...
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