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WO/2018/107450A1 |
This invention provides an electrochemical process for producing a propiolactone compound comprising reacting a compound having at least one ethylenically unsaturated carbon-carbon double bond with carbon dioxide in the presence of an el...
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WO/2018/107185A1 |
The present invention is directed to biodegradable polyester polyol polymers having high bio-based content and methods for producing biodegradable polyester polyol polymers having high bio-based content. In preferred embodiments, β-lact...
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WO/2018/101057A1 |
Provided are a compound useful as a mold release agent, a mold release agent containing same, a curable composition, and a nanoimprint lithography resin material. Specifically, the present invention provides: a calixarene compound with a...
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WO/2018/102419A1 |
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
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WO/2018/089402A1 |
There are described RORγ Gamma modulators of the formula (I), (I) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutic...
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WO/2018/079333A1 |
The present invention provides a spontaneous alignment assistant for liquid crystal compositions, which is capable of ensuring storage stability if added to a liquid crystal composition, while enabling vertical alignment of liquid crysta...
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WO/2018/071327A1 |
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...
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WO/2018/039376A1 |
The present invention relates to monoterpenoid and phenylpropanoid containing derivative compounds, methods of making the compounds, compositions comprising the compounds, and methods of repelling pests using the compounds and/or composi...
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WO/2018/010604A1 |
A group of polyfunctional oxetane compounds and a preparation method therefor. The compound is a compound in a structure as shown in general formula (I) or a product obtained by reacting the compound as shown in general formula (I) with ...
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WO/2017/215188A1 |
Provided are a taxoid compound as shown in formula (I) and a preparation method and use thereof, wherein the preparation method comprises the following steps of: firstly protecting the two hydroxyl groups of gemcitabine, then condensing ...
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WO/2017/192304A1 |
The present disclosure is directed to compounds of formula (I): or a pharmaceutically acceptable salt, solvate or solvate of the salt thereof. Compounds of formula (I) are inhibitors of NOX4 and are useful in the treatment of fibrotic di...
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WO/2017/190086A1 |
Provided herein are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in treating a condition, disease, or disorder associated with abnormal activation of the SREBP pathw...
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WO/2017/177004A1 |
Compunds of Formula (I) and pharmaceutically acceptable salts thereof, wherein G1, G2, G3, L1, L2, and L3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the modulation o...
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WO/2017/170808A1 |
To provide a technique for producing a four-membered ring lactone more efficiently with higher yield by means of a carbonylation reaction of an epoxide using a heterogeneous catalyst that is able to be handled in air and is easily separa...
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WO/2017/160925A1 |
Disclosed herein are compounds of Formulae (I), and (II), methods of synthesizing compounds of Formulae (I) and (II), and methods of using compounds of Formulae (I) and (II) as an analgesic.
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WO/2017/156165A1 |
The present invention provides compounds, compositions thereof, and methods of using the same.
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WO/2017/123760A1 |
This document relates to non-covalently bound complexes comprising cabazitaxel and human serum albumin. This document also relates to compositions comprising non-covalently bound complexes comprising cabazitaxel and human serum albumin. ...
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WO/2017/119515A1 |
An object of the present invention is to provide a novel ascochlorin derivative which activates adenosine monophosphate-activated protein kinase (AMPK), and is useful in the treatment or prevention of diseases or conditions that involve ...
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WO/2017/115301A1 |
The present disclosure provides methods for the treatment of breast cancer, including triple negative breast cancer. Said methods comprise the administration of (a) a cationic liposomal formulation comprising a taxane, (b) a non-liposoma...
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WO/2017/106957A1 |
This invention provides lipid-linked prodrugs having structures as set out herein. Uses of such lipid-linked prodrug compounds for treatment of various indications, and methods for making and using lipid-linked prodrugs are also provided.
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WO/2017/107907A1 |
The present invention relates to a condensed ring γ-amino acid derivative and a medical use thereof, and in particular relates to the condensed ring γ-amino acid derivative as shown in formula (I), or a stereisomer, a solvate, a metabo...
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WO/2017/097732A1 |
The invention relates to a compound of formula (I) wherein R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
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WO/2017/098291A1 |
The subject of the invention relates to a centrifugal partition chromatography (CPC) method serving for separating 10- deacetylbaccatin III, where the solution to be purified containing 10-deacetylbaccatin III is purified in at least one...
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WO/2017/088058A1 |
The present disclosure relates to peptide compounds and conjugate compounds, processes, methods and uses thereof for treating cancer and increasing cellular internalization of said peptide compounds. The peptide compounds are selected fr...
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WO/2017/075848A1 |
The present invention relates to the technical field of functional fine chemicals, and provides a method of preparing an environmentally friendly emulsifier of alkyl ketene dimers. The method comprises: placing sorbitan trioleate and a c...
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WO/2017/053391A1 |
The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule cytotoxins that are chemically modified to include one or more moieties that include hydrophobic port...
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WO/2017/049821A1 |
Disclosed is a water-soluble docetaxel anticancer pharmaceutical compound having the structure of formula I. The active moieties of the anticancer drug docetaxel and a polyethylene glycol monoalkyl ether form the water-soluble docetaxel ...
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WO/2017/049172A1 |
Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of condi...
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WO/2017/038871A1 |
The purpose of the present invention is to provide a compound having inhibitory activity with respect to the discoidin domain receptor 1. The present invention provides a urea derivative represented by the formula below or a pharmacologi...
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WO/2017/040537A1 |
Disclosed herein are embodiments of a method of accelerating bone healing in a subject in need thereof, comprising administering to the subject a compound disclosed here. The method may further comprise selecting or identifying a subject...
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WO/2017/025593A1 |
The invention relates to a method for insertion of carbon monoxide in at least one reactant component, characterized in that a reactant fluid which has at least one reactant component and carbon monoxide is contacted with a catalyst that...
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WO/2017/010399A1 |
Provided are compounds having RORγt inhibitory effects represented by formula (I). Compounds represented by formula (I) (wherein L represents -NR1ACO-, -SO2- or the like, A represents a substituted or unsubstituted aromatic carbocyclic ...
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WO/2017/006573A1 |
A side chain precursor of paclitaxel and docetaxel is provided at high purity, high yield, and low cost through a method for producing a compound shown by formula (3) using a compound shown by formula (1) as a starting compound. Using th...
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WO/2017/004478A1 |
The invention includes taxoid compounds represented by the formula: (1) wherein: R1 represents a methyl group or a fluorine; R2 represents an alkyl or alkenyl group having one to six carbon atoms; or a cycloalkyl or cycloalkenyl group ha...
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WO/2016/205202A1 |
The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertensi...
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WO/2016/198374A1 |
Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a di...
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WO/2016/172496A1 |
Provided are novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSDl. Also provided are pharmaceutical compositions ...
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WO/2016/168058A1 |
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...
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WO/2016/168056A1 |
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...
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WO/2016/131004A1 |
The integrated processes herein provide improved carbon efficiency for processes based on coal or biomass gasification or steam methane reforming. Provided are also ethylene oxide carbonylation products such as beta-propiolactone and suc...
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WO/2016/128131A1 |
Novel beta-lactone compounds are described. Also described are uses thereof, such as for inhibition of phospholipase A2 activity. Therapeutic uses thereof are also described, such as for the treatment of autoimmune conditions, and/or neu...
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WO/2016/119045A1 |
Compositions which comprise a hydrophobic taxane such as paclitaxel are produced by non-covalent complexing between the taxane and alpha-fetoprotein c at a ratio of about 4 moles of taxane per mole of AFP. The complexes are water soluble...
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WO/2016/114345A1 |
The present invention addresses the problem of providing a polymerizable compound and a polymerizable composition unlikely to cause a decrease in phase difference or discoloration when a film-shaped polymer obtained by polymerization is ...
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WO/2016/109501A1 |
The present invention is directed to amide compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment or prevention of diseases or disorders associated with peripheral ...
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WO/2016/098015A1 |
The present invention relates to a novel process for the preparation of taxanes such as Docetaxel, a very important anticancer drug. Docetaxel 1 is a clinically well-established anti -mitotic chemotherapy medication used mainly for the t...
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WO/2016/097389A1 |
The invention relates to benzenesulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of same as inverse agonists of retinoid-related orphan rece...
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WO/2016/077724A1 |
A compound, or pharmaceutically acceptable salt thereof, having a formula (I) wherein R1 is H or optionally-substituted alkyl; R2 is optionally-substituted alkyl; R3 and R4 are each independently H or optionally-substituted alkyl; R5 is ...
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WO/2016/069542A2 |
Provided herein are lactone compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as inhibitors of serine hydrolases, such as ABHD16A. Furthermore, the subject compounds an...
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WO/2016/066146A1 |
Disclosed is an ester compound containing an oxetane group. The compound has polyfunctionality, high stability and high cationic reaction activity, and is simple and convenient to prepare in a high yield. The ester compound can exhibit v...
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WO/2016/057322A1 |
Provided herein are deuterated compounds and compositions useful in increasing PPAR5 activity. The compounds and compositions provided herein are useful for the treatment of PPAR5 related diseases (e.g., muscular diseases, vascular disea...
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