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WO/2017/174382A1 |
The aim of the invention is to improve the cleaning power of detergents and cleaning agents in relation to stains. This is substantially achieved by incorporating N-methylpiperidine group-containing acyl hydrazones.
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WO/2017/170826A1 |
The purpose of the invention is to provide a compound useful in the prevention or treatment of diabetes, obesity, and conditions related thereto. The present invention relates to an enhancing agent for glucagon-like peptide-1 receptor ac...
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WO/2017/167180A1 |
The present invention provides a vortioxetine pamoic acid salt, which includes a crystal form, a solvate or an amorphous substance of the vortioxetine pamoic acid salt. The present invention provides a preparation method and use of the v...
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WO/2017/165822A1 |
A compound, or a stereoisomer, pharmaceutically acceptable salt, or ester thereof, according to formula (III) or according to Table A, a pharmaceutical composition comprising said compound and at least one pharmaceutically acceptable add...
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WO/2017/161524A1 |
Provided is a pyruvate dehydrogenase kinase inhibitor and an application therefor. Specifically provided is a compound Ra-S-S-Rb of formula X or a pharmaceutically acceptable salt thereof, the compound having excellent inhibition of pyru...
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WO/2017/162536A1 |
Prodrugs of vortioxetine are provided
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WO/2017/159484A1 |
[Problem] To provide an agent for inhibiting aggregation of tau and/or amyloid β. [Solution] A compound represented by formula (I) or a salt thereof. This compound is used in therapy, diagnosis, and symptom alleviation and in prevention...
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WO/2017/157882A1 |
The present invention relates to a compound of formula (I), a stereoisomer thereof, an enantiomer thereof, a racemic thereof, or a tautomer thereof as defined in claim 1 (I) the present invention also relates to a compound of formula (I)...
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WO/2017/153748A1 |
The present invention relates inter alia to a compound of formula (I) wherein R1, R2 and R3, are as defined in the specification and to compositions comprising the same and to the use of the compounds and to compositions of the compounds...
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WO/2017/154016A1 |
The present invention relates to novel crystalline polymorphs of 1 -[2-(2,4-dimethyl- phenylsulfanyl)-phenyl] -piperazine hydrobromide represented by the following structural formula- la and process for preparation thereof.
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WO/2017/156222A1 |
The present disclosure relates to compounds of Formula (I), compositions containing the compounds (alone or in combination with other agents), and their use to prevent, mitigate or treat damage induced by ionizing radiation.
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WO/2017/147701A1 |
The present application is directed to compounds of Formula I: (I) compositions comprising these compounds and their uses, for example as medicaments for the treatment of diseases, disorders or conditions mediated or treatable by inhibit...
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WO/2017/148455A1 |
The invention relates to iodinated aromatic choline analogs of general formula wherein at least one R is iodine; the quaternary ammonium group comprises a hydroxyl substituent, and further substituent are as defined in the claims. The co...
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WO/2017/147146A1 |
Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.
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WO/2017/144404A1 |
The invention relates to the manufacture of a compound of formula (I), wherein R1 is defined as in the description and in the claims.
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WO/2017/144181A1 |
The invention relates to a composition comprising a fluorine-containing surfactant having a cationic group, a divalent sulfur-containing group and a fluorinated group, further comprising an anion that corresponds to the cationic group of...
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WO/2017/141512A1 |
Provided is a catalyst represented by general formula (1), where R1-R16 in the general formula (1) individually represent a hydrogen atom or a substituent independently of each other.
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WO/2017/141775A1 |
The present invention relates to a lubricant containing an ionic liquid that has a conjugate base and a conjugate acid, wherein the conjugate acid has a group including a hydroxyl group and a group including a linear hydrocarbon group ha...
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WO/2017/140778A1 |
The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts, solvates and prodrugs thereof: Formula (I) wherein Q is selected from O, S and Se; J is S or Se; W1 and W2, when present, are independently...
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WO/2017/137047A1 |
The invention relates to a method for arylation of amines, such as aliphatic amines by reaction of aryl-halogens, e.g. chloro- or fluorobenzene derivatives without strongly electron withdrawing substituents in the presence of a strong base.
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WO/2017/137048A1 |
The invention relates to a method for synthesis of 1-[2-(2,4-Dimethyl-phenylsulfanyl)- phenyl]piperazine in the presence of a strong base.
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WO/2017/137530A1 |
The present invention relates to a process to prepare ethyleneamines of the formula NH2-(C2H4-NH-)pH wherein p is at least 2 wherein one or more units -NH-C2H4-NH- are present as a piperazine unit or precursors thereof wherein optionally...
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WO/2017/133591A1 |
The present invention discloses an N-sulfonyl benzamide derivative with a heterocyclic substituent, and a preparation method therefor and a pharmaceutical application thereof. More specifically, the invention discloses a compound represe...
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WO/2017/133913A1 |
The present invention relates to a process for the N-alkylation of amines by reacting an amine with an orthocarboxylic acid ester and with hydrogen in the presence of a hydrogenation catalyst.
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WO/2017/133429A1 |
The present invention discloses a terpineol and a preparation method and an application thereof. The terpineol has a structure represented by formulas (I) or (II). In formula (I), R is independently selected from C12 to C16 alkyl, -NR1R2...
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WO/2017/129061A1 |
Disclosed is an application of substituted cinnamamide derivatives in the preparation of Anti-anxiety medications, the substituted cinnammide derivatives are compounds having the structure of formula (I) or pharmaceutically acceptable sa...
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WO/2017/125673A1 |
The invention relates to a method for preparing a compound (I) or one of the salts thereof, and the uses of said method, R1OOC-C(=X)-CHR2 R3 (I), wherein X is selected among O; N-R', wherein R' is H or a C1-C6 alkyl; and N-OR'' wherein R...
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WO/2017/125504A1 |
The present invention provides novel polymorphic forms of vortioxetine hydrobromide (I).
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WO/2017/122697A1 |
The present invention provides a radiation-sensitive resin composition that contains: a first polymer having a first structural unit that contains a first acid-dissociable group; a radiation-sensitive acid generator; and a compound repre...
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WO/2017/119515A1 |
An object of the present invention is to provide a novel ascochlorin derivative which activates adenosine monophosphate-activated protein kinase (AMPK), and is useful in the treatment or prevention of diseases or conditions that involve ...
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WO/2017/112972A1 |
The invention relates to a method for producing ionic liquids based on bistriflimid anion. In a first stage, a primary aliphatic amine R-NH2 is reacted with triflic anhydride Tf2O so as to form corresponding N-alkylated triflic imid R-NT...
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WO/2017/116272A1 |
The invention relates to the field of the organic chemistry and, in particular to a method for preparing a compound of formula (I) or (II), and/or a mixture of isomers thereof, wherein R is -Alk, -AlkN(Alk)2, -AlkN(Ar)2, -AlkNAlkAr, -Alk...
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WO/2017/114497A1 |
Provided are the use of LSD1 inhibitors in connection with use and manufacture of immune effector cells (e.g., T cells, NK cells), e.g., engineered to express a chimeric antigen receptor (CAR), to treat a subject having a disease, e.g., ...
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WO/2017/113439A1 |
Provided are a plating additive for electrodeposition, and the corresponding fabrication method thereof. The plating additive enables to electroplate holes on a substrate with good height uniformity within a feature and among features at...
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WO/2017/106957A1 |
This invention provides lipid-linked prodrugs having structures as set out herein. Uses of such lipid-linked prodrug compounds for treatment of various indications, and methods for making and using lipid-linked prodrugs are also provided.
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WO/2017/111878A1 |
Reinforcing bars include load transfer connectors. A link plate includes openings that mate with the load transfer connectors to overlie the splice between reinforcing bars being spliced. A cover plate may be fastened over the link plate.
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WO/2017/112865A1 |
The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanop...
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WO/2017/102802A1 |
The present invention relates to a compound of formula (I) for its depigmenting, lightening and/or bleaching the skin in which R1 and R2 independently denote H, an alkyl radical, a radical S* denoting a monosaccharide sugar radical or a ...
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WO/2017/101791A1 |
Disclosed are a compound and a use thereof in preparing a drug, and in particular, provided in the present invention are: the compound as shown in formula (I) or a stereoisomer, a geometric isomer, a tautomer, a racemate, a nitroxide, a ...
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WO/2017/100045A1 |
The present invention provides a novel partially fluorinated piperazine sulfonamide compound, and polymer composition comprising the fluorinated compound and a thermoplastic or thermoset polymer. The polymer composition is useful in prep...
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WO/2017/096997A1 |
Provided is a preparation method for cariprazine (RGH 188). Preparation steps comprise: a condensation reaction between 4-(2-hydroxyethyl)cyclohexanone and 1- (2,3-dichlorophenyl)piperazine to produce 4-[2-[4-(2,3-dichlorophenyl) piperaz...
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WO/2017/097891A1 |
The invention relates to crystalline eravacycline and to a process for its preparation. Furthermore, the invention relates to the use of crystalline eravacycline for the preparation of a pharmaceutical composition. The pharmaceutical com...
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WO/2017/093491A1 |
The invention relates to Compound (I), which is 4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-d
ifluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-
1-yl)-N-(4-fluorophenyl)benzamide, or a pharmaceutically acceptable...
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WO/2017/087257A1 |
The present invention relates to Amido-Substituted Pyridotriazine Derivatives of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein B, X, Y, R, R1, R2 and R10 are as defined herein. The present invention also relates...
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WO/2017/087256A1 |
The present invention relates to Spirocyclic Pyridotriazine Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, R1, R2 and R10 are as defined herein. The present invention also relates to composi...
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WO/2017/078149A1 |
Disclosed is an additive for nonaqueous electrolyte solutions, which contains a disulfonic acid amide compound represented by formula (1). In formula (1), A represents CmH(2m-n)Zn; m represents an integer of 1-6; n represents an integer ...
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WO/2017/077550A1 |
The present invention discloses a novel metal free process for the regioselective synthesis of α-substituted carbonyl compounds of formula I from alkene, X is selected from the following compounds (A, B).
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WO/2017/076771A1 |
The present invention relates to selected acylhydrazone compounds, their use as oxidation catalysts and to a process for removing stains and soil on textiles and hard surfaces. The compounds contain two acylhydrazone groups per molecule ...
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WO/2017/077152A1 |
A process for obtaining a compound of formula (I), wherein each R 1 represents C1-4alkyl.
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WO/2017/070084A1 |
The disclosed subject matter provides N- hydroxylsulfonamide derivative compounds of formulae (I), (II) or (III) as drawn below, pharmaceutical compositions comprising such compounds, kits comprising such compounds, and methods of using ...
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