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WO/1998/008829A1 |
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as anti-neoplastic agents, and for the treatment of cancer. The invention further provides a formulation for administering th...
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WO/1998/008506A1 |
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as anti-neoplastic agents, antifungal, and for the treatment of cancer. The invention further provides a formulation for admi...
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WO/1998/008505A1 |
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as anti-neoplastic agents, and for the treatment of cancer. The invention further provides a formulation for administering th...
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WO/1998/008812A1 |
This invention provides processes for preparing cryptophycin compounds and novel intermediates which are useful in such processes.
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WO/1998/006710A1 |
Compounds of formula (I), in which A is a substituted or unsubstituted heterocyclyl group; -E-R is -C(=O)-R, -C(=O)O-R, -C(=O)N(R�1?)-R, -C(=O)C(=O)-R, -C(=O)C(=O)O-R, -C(=O)C(=O)N(R�1?)-R or -C(=S)N(R�1?)-R; R is hydrogen or a sub...
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WO/1998/006709A1 |
The present invention relates to a cyclic urea or thiourea compound comprising (i) a group of formula (I') wherein Q?1� represents an aromatic ring group which may optionally be substituted; and R?1� and R?2� are the same or differ...
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WO/1998/005655A1 |
Substance PF1022G, a novel cyclodepsipeptide represented by formula (D), is produced together with known cyclodepsipeptides, i.e., Substances PF1022F and PF1022H by culturing a bacterium which produces the Substances PF1022F, PF1022G and...
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WO/1998/005656A1 |
Oxadiazines of formula (I), wherein R?1� is F, Cl or fluoralkoxy and R?2� is alkyl, are prepared by reacting hydrazine derivatives of formula (II) with a dialkoxymethane in the presence of a protic acid catalyst in an inert solvent u...
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WO/1998/004247A1 |
The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds...
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WO/1998/004247A2 |
The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds...
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WO/1998/004913A1 |
Pharmacophore models of VLA-4 inhibitors, methods of identifying novel inhibitors and novel inhibitors identified by these methods.
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WO/1998/002501A1 |
The present invention provides a method for scavenging sulfyhydryl compounds from sour hydrocarbon substrates, preferably crude oils, refined distillate streams, and natural gas, by mixing said substrates with preferably substantially wa...
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WO/1997/046542A1 |
The invention concerns a plurality of novel processes and novel intermediate products for preparing 3-(1-hydroxyphenyl-1-alkoximinomethyl)dioxazines which are known (WO-A-95/04728) as initial products for preparing compounds having fungi...
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WO/1997/036883A1 |
The invention concerns novel (1,3,4)-oxadiazine derivatives of formula (I) in which: R1 and R2, independently of each other, stand for hydrogen, or for alkyl, hydroxylalkyl, alkanoyloxyalkyl, alkoxyalkyl, arylalkoxyalkyl, mercaptoalkyl, ...
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WO/1997/032844A1 |
The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
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WO/1997/031632A1 |
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as antineoplastic agents, and for the treatment of cancer. The invention further provides a formulation for administering the...
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WO/1997/027189A1 |
Compounds of formula (I) in which: A is for alkanediyl optionally substituted as necessary; R stands for cycloalkyl, aryl or benzo condensed heterocyclyl, each of this group optionally being substituted; E stands for -CH= or nitrogen; Q ...
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WO/1997/023211A1 |
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as antineoplastic agents, and for the treatment of cancer. The invention further provides a formulation for administering the...
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WO/1997/020945A1 |
The invention relates to a new process for the preparation of substituted aryl lactic acid containing cyclodepsipeptides with 24 ring atoms of the formula (I), in which R1, R2, R3, R4 have the meanings given in the description, with the ...
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WO/1997/018207A2 |
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tis...
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WO/1997/017322A1 |
Disclosed are "acid-amide" calixarenes of formula (I) wherein: L is [-CH2-] or [-O-CH2-O-] and may be the same or different between each aryl group; R5 is H, halogen, or C1-C10 aliphatic hydrocarbyl group, C6-C20 aryl group, C6-C20 hydro...
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WO/1997/013504A1 |
The invention refers to pharmaceutical compositions suitable for the protection of the mitochondrial genome and/or mitochondrium from damages or for the treatment of diseases connected with such damages, said compositions comprising a hy...
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WO/1997/011071A1 |
A compound of formula (I), wherein R1 and R2 independently are hydrogen, halogen, trifluoromethyl, hydroxy, C1-6-alkyl or C1-6-alkoxy; and R3 is hydrogen or C1-3-alkyl; and A is C1-3-alkylene; and Y is >CH-CH2-, >C=CH-, >CH-O-, >C=N-, >N...
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WO/1997/011064A1 |
Novel PF1022 derivatives which are cyclic depsipeptides represented by general formula (I) or their salts are useful as a vermicide in the prevention or treatment of vermination.
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WO/1997/007798A1 |
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as antineoplastic agents, antifungal, and for the treatment of cancer. The invention further provides a formulation for admin...
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WO/1997/008334A1 |
Methods for producing cryptophycin compounds by bacterial fermentation are disclosed, together with novel compositions produced thereby.
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WO/1997/002256A1 |
A novel industrial process for producing an anthelmintic depsipeptide derivative represented by structural formula (I), which is excellent in the yield etc.
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WO/1997/000866A1 |
Compounds of formula (I) and their possible isomers and isomer mixtures, in which (Z) is a group (a), (b), (c) or (d) and in which the other substituents are as defined herein. They can be used for pest control, in particular as microbic...
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WO/1996/040626A1 |
a water-containing composition containing a linear aminoplast-ether copolymer of formula (I), where the divalent R01 contains a divalent alkyleneoxy containing moiety; Amp is the skeletal residue of an aminoplast, R is hydrogen, alkyl co...
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WO/1996/040108A1 |
The invention relates to multidentate metal complexes having formula (I) wherein M is Fe, In, Ga or Al; the dashed lines represent independently a sigle or a double bond; the hatched lines represent coordination to the metal cation (M); ...
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WO/1996/040184A1 |
Novel cryptophycin compounds are disclosed, together with methods of producing cryptophycins by total synthesis and methods for the use of such cryptophycins in pharmaceuticals to inhibit the proliferation of mammalian cells and to treat...
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WO/1996/039829A1 |
The present invention provides novel cryptophycin compounds having structure (I). The present invention also provides methods for producing novel cryptophycins from the Nostoc sp. of blue-green algae (cyanobacteria). Pharmaceutical compo...
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WO/1996/038165A2 |
The present invention relates to mixtures of avermectines, 22,23-dihydroavermectines B1 (ivermectines) and milbemycines from the macrocyclic lactone class in combination with cyclic depsipeptides, possibly in the presence of praciquantel...
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WO/1996/036618A1 |
Compounds of formula (Ia) wherein Z is (a), wherein x is an integer from 0 to 4, n is an integer from 0 to 5 and R is defined below; or (b), wherein n is an integer from 0 to 5 and R is defined below; R is selected from the group consist...
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WO/1996/031467A1 |
Provided is a compound of formula (I). This compound is an intermediate to and is used for preparing the arthropodicidal oxidiazine Compound (II) described in the specification.
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WO/1996/030348A1 |
The present invention provides an efficient process of reacting a bis-indolyl acid of Formula (II), wherein R1 is a hydrogen or C1-C4 alkyl and R, X, and Y are optional substitutions; to produce a bis-indolyloxallic acid of Formula (III)...
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WO/1996/030377A1 |
Novel macrocyclic compounds are constructed to include large cyclic structures that are interrupted by at least one ring sytem. Each interrupting ring system includes two bridgehead atoms. Bridgehead atoms are bonded to one or more bridg...
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WO/1996/025406A1 |
Compounds of formula (I) in which A is possibly substituted alkylene, Ar is possibly substituted arylene or heteroarylene, E is preferably one of the grouping (a), (b), (c), (d), (e), Y1 is oxygen, sulphur or a possibly alkyl-substituted...
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WO/1996/022983A1 |
The invention relates to novel substituted arylazadioxacyclo alkenes of formula (I), several processes for their production and their use as fungicides.
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WO/1996/018624A1 |
The invention concerns novel 1,3,4-oxadiazine derivatives of formula (I) in which Ar1 stands for in each case optionally substituted aryl or hetaryl; Ar2 stands for in each case optionally substituted aryl or hetaryl; and X stands for th...
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WO/1996/016950A1 |
A HIV-1 protease inhibitor which includes an N-terminal cycle (A) or a C-terminal cycle (B) or both cycles (A) and (B) wherein Y is selected from side chains of Asn or Ile or Val or Glu and alkyl of 1-6 carbon atoms inclusive of linear o...
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WO/1996/015131A1 |
This invention provides a process for producing a macrocyclic lactone compound, which comprises cultivating Actinoplanes sp. FERM BP-3832, in the presence of L-proline, L-hydroxyproline or L-nipecotic acid, and then isolating a macrocycl...
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WO/1996/013260A1 |
A compound having formula (I) wherein Me represents a methyl group, having an antibacterial activity.
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WO/1996/011945A2 |
A process is disclosed for the aromatic sulfonylation, sulfenylation, thiocyanisation and phosphorylation of cyclic depsipeptides with 6 to 24 ring atoms, composed of 'alpha'-hydroxycarboxylic acids and 'alpha'-aminoacids and containing ...
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WO/1996/011191A1 |
3- and 5-substituted 1,2,3,4-oxatriazole-5-imine compounds of general formula (I), wherein R1 is the same or different groups and represents alkyl or alkoxy groups having 1 to 3 carbon atoms, halogen, trifluoromethyl, nitro, cyano, pheny...
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WO/1995/029171A1 |
A method for making arthropodicidal oxadiazines and intermediates which are racemic or enantiomerically enriched at their chiral center, the method for making the oxadiazines comprising reaction of an intermediate selected from (II) or (...
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WO/1995/028392A1 |
The invention provides amphiphilic compounds of the formula (I) Ch-(-L-Ar-(-AH)n)m (where Ch is a hydrophilic chelant moiety or a salt or a chelate thereof); each L is an optionally oxo substituted C2-25-alkylene linker wherein at least ...
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WO/1995/027498A1 |
The invention concerns the use, to control parasitic protozoans, in particular coccidia, and fish parasites, of cyclic depsipeptides in which the 18-atom ring is made up of amino-acid and hydroxycarboxylic acid units and which have gener...
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WO/1995/026723A1 |
This invention relates to novel substituted tryptamine and phenalkylamine and related compounds, pharmaceutical compositions thereof and methods of using said compounds and compositions for a number of pharmaceutical indications includin...
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WO/1995/022523A1 |
A cyclic nitrogenous compound represented by general formula (1) and a herbicide containing the same, exhibiting a high herbicidal activity in a small dose, and having crop selectivity: wherein R1 represents alkyl; R represents hydgrogen...
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