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WO/2019/076324A1 |
Disclosed are a salt of indoleamine-2,3-dioxygenase inhibitor and a preparation method therefor. In particular, disclosed are a salt of a compound of formula I and a variety of amorphous substances and polymorphs thereof, wherein the def...
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WO/2019/076904A1 |
The application relates to compounds of formula (I) that show great affinity and activity towards the subunit α2δ of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels or dual activi...
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WO/2019/073399A1 |
The invention relates to crystalline forms of a 3-substituted 1,2,4-oxadiazole compound, methods of their preparation, and related pharmaceutical preparations thereof. The invention also relates to preparations suitable for pharmaceutica...
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WO/2019/067678A1 |
The invention relates to crystalline forms of a 3-substituted 1,2,4-oxadiazole compound, including an anhydrous crystalline form, methods of their preparation, and related pharmaceutical preparations thereof. The invention also relates t...
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WO/2019/058290A1 |
The present invention relates to an improved process for the preparation of optically chiral amino compound. The present invention particularly relates to the improved process for the preparation of (S)-1-amino-2,3-dihydro-1H-indene-4-ca...
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WO/2019/057104A1 |
The present invention relates to a salt of a dioxygenase inhibitor and a preparation method therefor and the use thereof, in particular relates to a salt of (Z)-N-(3-bromo-4-fluoro-phenyl)-4-((2-(N-(cyclopropylsulfony
l)-S-methylsulfinyl...
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WO/2019/052932A1 |
The present invention relates to novel trifluoromethyloxadiazoles of the formula I as defined herein, or an N-oxide and/or their agriculturally useful salts and to their use for controlling phytopathogenic fungi; to a method for combatin...
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WO/2019/042219A1 |
The present invention relates to a crystalline form of ozanimod hydrochloride and a preparation method therefor. The crystalline form of ozanimod hydrochloride provided by the present invention can be used to treat autoimmune diseases, p...
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WO/2019/040724A1 |
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having an oxadiazole-oxadiazolone structure (e.g., oxadiazole-phenyl-oxadiazolone compounds, oxadiazole-pyridin...
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WO/2019/038042A1 |
The present invention relates to trifluoromethyloxadiazoles of the formula I, or the N-oxides, or the agriculturally useful salts thereof, and the use thereof for controlling phytopathogenic fungi; to a method for combating phytopathogen...
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WO/2019/040404A1 |
The present invention is related to the development of therapeutics and prophylactics for the treatment and/or prevention of bacterial infections in humans and other mammals. A new class of small molecules is disclosed that inhibits the ...
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WO/2019/025250A1 |
The present invention relates to trifluoromethyloxadiazoles of the formula I, or the N-oxides, or the agriculturally useful salts thereof, and the use thereof for controlling phytopathogenic fungi; to a method for combating phytopathogen...
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WO/2019/020451A1 |
The present invention relates to a process for the preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles (compounds I), which can be obtained through reaction of hydroxyamidine compounds of formula II with trifluoroacetyl...
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WO/2019/020501A1 |
The present invention relates to a process for the preparation of 3-aryl-5-trifluoromethyl-1,2,4- oxadiazoles, which are useful as fungicidal compounds or as intermediates for the synthesis of fungicidal oxaciazole compounds, using trifl...
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WO/2019/022061A1 |
This fungicide for agricultural and horticultural use includes a compound represented by formula (I) (in the formula, X represents a halogen group, etc.; n represents any integer of 0-4; when n is 2 or higher, X may be the same or differ...
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WO/2019/011078A1 |
Provided is oxadiazole linkers and use thereof, more specifically to the compounds represented by formulas (I), (II), and (III), and their use in the preparation of antibody-drug conjugates (ADCs). The ADCs obtained from said oxadiazole ...
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WO/2019/013299A1 |
The present invention provides a thermally conductive material that has excellent thermal conductivity. The present invention also provides: a device that is provided with a thermally conductive layer that includes the thermally conducti...
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WO/2019/011170A1 |
Provided are: an oxadiazole derivative as shown in formula (1), or salts, esters, stereoisomers, tautomers, polymorphs, solvates, hydrates, metabolites or prodrugs thereof, or a mixture of said substances; a pharmaceutical composition co...
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WO/2019/010192A1 |
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, tautomers, N-oxides, and salts thereof, wherein R1, Z1, W, Z2 and J are as defined in the disclosure. Also disclosed are compositions containing the compoun...
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WO/2019/007321A1 |
Disclosed in the present invention are an indoleamine-2,3-dioxygenase inhibitor compound, a preparation method therefor, and an application thereof. The indoleamine-2,3-dioxygenase inhibitor compound provided by the present invention is ...
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WO/2019/009412A1 |
The present invention addresses the problem of providing a novel compound having high LSD1 inhibitory activity, high selectivity for LSD1 inhibition, and/or having useful therapeutic effects for various diseases. One embodiment of the pr...
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WO/2019/001342A1 |
The present invention belongs to the field of medicine, and specifically discloses an amino alcohol derivative represented by Formula I, a pharmaceutically acceptable salt, solvate, polymorph or prodrug thereof. In addition, the present ...
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WO/2017/191000A9 |
Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a di...
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WO/2018/234139A1 |
2-[[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]aryloxy](thio)a
cetamides for combating phytopathogenic fungi The present invention relates the compounds of the formula I and their N-oxides and agriculturally acceptable salts thereof, and t...
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WO/2018/227886A1 |
Provided in the present invention are a new type indoleamine 2,3-dioxygenase inhibitor and a preparation method and pharmaceutical composition thereof, wherein the definitions of the R and X groups are as shown in the description. Also p...
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WO/2018/230528A1 |
Provided are a novel nitrocatechol derivative having COMT inhibitory effect and DDC inhibitory effect or a salt thereof and a medicinal composition comprising the same. A compound represented by general formula (1) or a pharmaceutically ...
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WO/2018/230555A1 |
The present invention provides a compound represented by formula (1)( in formula (I), R1 represents a substituted or unsubstituted C1-6 alkyl group; R2 represents a substituted or unsubstituted C1-8 alkyl group; R3 represents a hydrogen ...
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WO/2018/224455A1 |
The invention relates to cyclopropyl compounds of formula (I), wherein the variables have the meanings as defined in the specification, to compositions comprising them, to active compound combinations comprising them, and to their use fo...
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WO/2018/219935A1 |
The invention relates to benzamides of formula (I), wherein Q is Q1 or Q2 or Q3 or Q4 (formulae (Q1), (Q2), (Q3), (Q4)); and their use as herbicides. In said formula (I), R2 is R2cR2dNC(O)NR2n-Z2, both R4 and R5 are hydrogen, R1, R3 and ...
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WO/2018/219936A1 |
The invention relates to benzamides of formula (I), wherein Q is Q1 or Q2 or Q3 or Q4, and their use as herbicides. In said formula (I), R2 is R2cR2dNC(O)NR2n-Z2, R5 is hydrogen, R1, R3, R4 and R6 represent groups such as hydrogen, halog...
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WO/2018/219797A1 |
The present invention relates to substituted oxadiazoles of the formula (I), or the N-oxides, or the agriculturally useful salts thereof, and to the use thereof for controlling phytopathogenic fungi; to a method for combating phytopathog...
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WO/2018/215818A1 |
The present invention relates to compounds of formula (I): wherein Q is O or S; R1 is a cyclic group substituted with at least one group X, wherein R1 may optionally be further substituted; X is any group comprising a carbonyl group; and...
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WO/2018/214958A1 |
Disclosed are a crystal form of an indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor and a preparation method therefor.
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WO/2018/215807A1 |
The present invetion relates a new process for the preparation of ozanimod of the formula and acid addition salts, via new intermediates and a new polimop form of ozanimod base.
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WO/2018/213537A1 |
A label for an antibody or protein is described that is both site-selective and unusually stable in vivo. The label has a general formula given by Formula (I) wherein R1 is a metal chelator, a fluorophore or a click-chemistry synthon.
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WO/2018/202491A1 |
Substituted trifluoromethyloxadiazoles for combating phytopathogenic fungi The present invention relates to trifluoromethyloxadiazolesof the formula I, or the N-oxides, or theagriculturally useful salts thereof, and the use thereof for c...
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WO/2018/202535A1 |
Substituted benzoyl amides and their use as herbicides. The invention relates to benzoyl amides of general formula (I) as herbicides. In formula (I) X, R and Ra represent radicals such as alkyl, cycloalkyl and halogen. Q is a five-member...
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WO/2018/202694A1 |
The present invention refers to compounds of the following formula (I) or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions containing them and to a process for the preparation of said compounds: Formula (I), whe...
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WO/2018/202428A1 |
Fungicidal mixture comprising substituted 3-phenyl-5-(trifluoromethyl)-1,2,4-oxadiazoles The present invention relates to fungicidal mixtures comprising at least one substituted 3- phenyl-5-(trifluoromethyl)-1,2,4-oxadiazoles (compounds ...
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WO/2018/196747A1 |
The present invention belongs to the field of medical technology. Particularly, the present invention relates to a compound shown in formula (I), a pharmaceutically acceptable salt thereof, and a stereoisomer of the same. X, Y, Z, R1, R2...
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WO/2018/196861A1 |
The present invention relates to the field of pharmaceuticals, and in particular to a guanidine derivative containing a furan structure and a composition thereof. The derivative and the composition thereof can be used for preparing pharm...
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WO/2018/196768A1 |
The present invention relates to the field of medical chemistry, and relates to a heterocyclic compound serving as a PD-L1 inhibitor. Specifically, the present invention relates to a compound represented by formula A, or an isomer, pharm...
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WO/2018/193297A1 |
The present invention provides compounds which are modulators of RORϒ and their use for the treatment of diseases or conditions mediated by RORϒ. Further, the present invention relates to processes of preparing such compounds, their ta...
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WO/2018/188962A1 |
The present invention relates to novel trifluoromethyloxadiazoles of the formula (I), or the N-oxides, or theagriculturally useful salts thereof; and to intermediates that are useful for their preparation; and to the use of compounds of ...
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WO/2018/189340A1 |
The present invention relates to novel benzohydroxamic compounds of formula (I) and (II) and pharmaceutically acceptable salts, isomers and prodrugs thereof, exhibiting a high selective inhibitory activity against histone deacetylase 6 (...
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WO/2018/185211A1 |
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as pesticides, especially as fungicides.
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WO/2018/185013A1 |
Compounds of the Formula (I) wherein the substituents are as defined in claim 1, useful as pesticides, especially as fungicides.
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WO/2018/184585A1 |
The present invention provides a compound for inhibiting IDO, a manufacturing method and a use thereof. The compound has a general structural formula of (I), wherein (II) is selected from a cis-isomer, a trans-isomer, or a mixture of cis...
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WO/2018/184986A1 |
Compounds of the formula (I): wherein the substituents are as defined in claim 1, useful as pesticides, especially as fungicides.
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WO/2018/184982A1 |
Compounds of the formula (I): wherein the substituents are as defined in claim 1, useful as pesticides, especially as fungicides.
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