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JP2000511177A |
Compounds selected from the group consisting of formulae III, IV, VI and VIIIwherein R is H is NH2, or a pharmacologically acceptable salt thereof, are suitable for use in methods for treating non-insulin-dependent diabetes mellitus (NID...
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JP3058806B2 |
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JP2000505473A |
(57) [Summary] The present invention provides novel cryptophycin compounds that may be useful in disrupting the microtubule system as antitumor agents and for treating cancer. The present invention further provides a preparation for admi...
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JP2000504728A |
Compounds of Formula I I and Formula III III which are useful in the treatment of thrombin and trypsin related disorders.
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JP3014146B2 |
The present invention provides an efficient process of reacting a bis-indolyl acid of the Formula (II): (II) wherein R1 is a hydrogen or C1-C4 alkyl and R, X, and Y are optional substitutions; to produce a bis-indolyloxallic acid of the ...
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JP2000502050A |
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tis...
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JPH11513376A |
The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective beta 3 receptor agonists useful in the treatment of Type II d...
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JP2979188B1 |
[wrap up] [Task] A copper complex having high solubility in an organic solvent is provided. A copper complex represented by the following general formula (I). [Chemical 1] (In the equation, n is an integer greater than or equal to 1, X i...
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JPH11511733A |
Aziridines may be subjeted to a cyclooligomerization reaction to produce polyazacycloalkane compounds useful for example in the preparation of chelating agents for use in diagnostic imaging contrast agents. N-benzyl-aziridine in particul...
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JPH11510792A |
The application concerns a method of identifying compounds that can be used to inhibit undesired human CD4+ T cell immune responses by identifying compounds that block the interaction of CD4 and MHC, class II, gene products and a method ...
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JPH11508604A |
The present invention relates to the design and synthesis of linear and cyclic inhibitors of cathepsin D and plasmepsins I and II. The present invention also relates to the uses of these inhibitors for inhibiting invasion and metastasis ...
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JPH11189573A |
To obtain a new compound useful for the production of a polymer precursor excellent in solubility and capable of producing, on a substrate, after cyclized, polybenzoxazole or polybenzothiazole having low hygroscopicity, high temperature ...
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JPH11158129A |
To obtain the subject new compound suitable for producing polymers satisfying the increasing demands of microelectronics. An o-aminophenol carboxylic acid and an o-aminothiophenol carboxylic acid of formula I {A1-A7 are each H, CH3, OCH3...
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JPH11140061A |
To provide the subject new compound that is useful as a detergent or cleaning agent that can contain peroxy compounds in no need of addition of any heavy metal ion source, and as a catalyst. This new compound is a cyclic polymine salt of...
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JP2894839B2 |
A process for the purification of aminophosphonic acids under non-alkaline conditions is described. In particular, aminophosphonic acids are slurred in neutral or acidic water, heated to reflux, cooled and then filtered. Product purities...
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JP2877844B2 |
Macrocyclic compounds of the general formula I in which @is a single or double bond, q is the numbers 0-5, A and B, which are identical or different, are each a straight-chain or branched alkylene group with 2 to 6 carbon atoms, D is a n...
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JPH11500130A |
A method of inhibiting viruses in which a virus is contacted with an antiviral amount of a compound of formula I. Activity is shown against HIV and other viruses. formula I: wherein W is a bridge carbon which has a polar or non-polar sid...
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JP2788550B2 |
An improved process is described for obtaining triazacyclononanes, esepcially 1,4,7-trimethyl-1,4,7-triazacyclononame. The first step involves reacting diethylenetriamine (DET) with a sulfonylation agent to form a sulfonamidated DET, in ...
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JPH10508036A |
Novel macrocyclic compounds are constructed to include large cyclic structures that are interrupted by at least one ring system. Each interrupting ring system includes two bridgehead atoms. Bridgehead atoms are bonded to one or more brid...
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JP2764262B2 |
The present invention relates to novel hydantoin derivatives, processes for producing said hydantoin derivatives, pharmaceutical compositions containing at least one of said hydantoin derivatives as aldose reductase inhibitors and novel ...
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JP2714724B2 |
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JPH09512004A |
PCT No. PCT/GB95/00833 Sec. 371 Date Jan. 17, 1997 Sec. 102(e) Date Jan. 17, 1997 PCT Filed Apr. 12, 1995 PCT Pub. No. WO95/28392 PCT Pub. Date Oct. 26, 1995The invention provides amphiphilic compounds of the formula (I) Ch-(-L-Ar-(-AH)n...
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JP2683080B2 |
Ti-aza macrocycles of formula (1), wherein m and n, which may be the same or different, is each zero or an integer 1, 2, or 3; p is zero or an integer 1 or 2; q is zero or an integer from 1 to 6 inclusive; R1, R2 and R3, which may be the...
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JP2675058B2 |
Ligands and complexes of the title and the applications of these complexes in magnetic resonance imaging, in X-ray radiology and as in-vivo chemical shift agents.
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JPH09507668A |
The present invention provides new and structurally diverse compositions comprising compounds of the general formula: Wherein U is -(CH2)nX or -(CH2)nNR1(CH2)X; R1 is hydrogen, C1-C8 alkyl, C1-C8 hydroxyalkyl or C1-C8 alkoxyalkyl; V is -...
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JP2622673B2 |
PURPOSE: To obtain a therapeutic agent for asteroporosis comprising a new triazepine compouns as an active ingredient useful for treating Paget's disease, osteoporosis, etc., having excellent inhibitory action on bone resorption and low ...
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JP2613707B2 |
PURPOSE: To obtain a novel bleach and an oxidation catalyst, to provide a method for bleaching a substrate using the oxidation catalyst and a bleaching (detergent) compsn. contg. the catalyst. CONSTITUTION: The catalyst is a manganese-ba...
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JPH09503497A |
(57) [Summary] The present invention has the general formula (I): W- (A).n-B- (A*)m-For V retroviral protease inhibitors, W, A, B, A*, V, n, m are defined herein and include the relevant prodrugs of formula (I) containing soluble groups ...
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JPH0987260A |
To obtain a new condensed ring compound having cholesterol-lowering action and triglyceride-lowering action as well as low toxicity and safety and useful for preventing and treating hyperlipemia. This compound is represented by formula I...
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JP2578573B2 |
PURPOSE: To obtain a polycarbonate resin composition useful for a building material, etc., having sufficient weather resistance by mixing a polycarbonate resin with a benzotriazole compound as an ultraviolet absorber and a coumarin compo...
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JPH0920762A |
To obtain a chiral manganese-triazanonane complex, which is a catalyst enabling the production of chiral compounds on an industrial scale. This complex is represented by formula I [u and v are each 1 or 2; w, x and y are each 0, 1, 2, 3;...
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JPH09500120A |
PCT No. PCT/EP94/02235 Sec. 371 Date Jan. 11, 1996 Sec. 102(e) Date Jan. 11, 1996 PCT Filed Jul. 7, 1994 PCT Pub. No. WO95/02582 PCT Pub. Date Jan. 26, 1995This invention relates to substituted cyclic carbonyls and derivatives thereof us...
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JPH08512297A |
Contrast agents particularly useful for X-ray diagnostic examinations of vascular system of the human and animal body are disclosed.
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JPH08311023A |
PURPOSE: To obtain the subject compound at a high reaction rate, high conversion and high selectivity and in high concentration with suppressing decomposition of the product without by-product such as formic acid or acetic acid by using ...
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JP2547348B2 |
New 9-anthrylalkyl compounds having the general formula wherein R is hydrogen or an alkyl group, whereby, however, not more than one of the groups R is an alkyl group; R1 is hydrogen, lower alkyl, halogen or nitro; n is an integer of fro...
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JPH08231987A |
To inhibit the re-absorption of migrating dyes in the wash liquor without causing discoloration of cotton, polyamide, polyester fibers, etc., by introducing a specified amt. of a specific org. manganese complex into a wash liquor contg. ...
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JPH08157369A |
PURPOSE: To obtain the subject lowering agent, containing a condensed ring compound represented by a specific formula and useful for preventing and treating hyperlipemia, above all, preventing and treating hypertriglyceridemia according ...
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JPH0827129A |
PURPOSE: To obtain a new compound useful as an antiviral agent and further the new antiviral agent containing the compound as an active ingredient. CONSTITUTION: This cyclic polyamine compound comprises a 2C, a 3C or a 4C alkylene chain ...
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JPH07110854B2 |
Azole derivative of the general formula (I) in which A, L, O, R<1>, X, Y, Z and q have the meanings given, a process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the ...
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JPH07179464A |
PURPOSE: To mass-produce via a simple route the subject compound useful as a synthesis intermediate for an angiotensin II antagonist by a novel process comprising cyclizing a specifically obtained amidine with a specified dicarbonyl comp...
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JPH0765074B2 |
Novel bleach and oxidation catalysts, a method of bleaching substrates using these catalysts and bleaching (detergent) compositions containing the catalysts are reported. The catalysts are a manganese-based co-ordination complex of the g...
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JPH07149741A |
PURPOSE: To dramatically reduce the necessary dispersant amount and to produce a desired product in a good yield with a high purity by carrying out an azo coupling reaction by using a specific dispersant. CONSTITUTION: A substituted 2-ni...
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JPH07502994A |
The pH controlled selectivity of the sulfomethylation reaction is used to prepare a series of di-, tri-, tetra- and hexaazacyclomacrocycles with specified patterns of pendent side-chain chelating groups. The prepared mono and diacetic ac...
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JPH06339390A |
PURPOSE: To obtain a new compound having a prolyl endopeptidase-inhibiting activities and useful for treatment or the like of amnesia, dementia or the like. CONSTITUTION: This new compound is a compound of the formula (R is a 1-4C alkyl,...
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JPH06510741A |
(57) [Summary] Since this publication is application data before electronic filing, summary data is not recorded.
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JPH06263742A |
PURPOSE: To obtain a new azole compound having excellent aromatase inhibiting action and especially useful as a therapeutic agent for breast cancer. CONSTITUTION: A compound of formula I [R is 1-immdazolyl, 4-imidazolyl, 5-imidazolyl, 1-...
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JPH06256512A |
PURPOSE: To obtain a new compound containing a molecular recognition space, having excellent organism-like functionality and substrate specificity and useful as catalyst, etc. CONSTITUTION: The compound of formula I [R10N and NR20 are gr...
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JPH06507176A |
This invention concerns cyclic aromatic amide oligomer compositions and a process for preparing such cyclic oligomers.
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JPH06179629A |
PURPOSE: To obtain a heterocyclic antagonist of an angiotensin II receptor which is useful as a drug to prevent or cure coronary cardiopathy, function disabilities in recognition and erection, kidney and immunological diseases. CONSTITUT...
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JPH06157444A |
PURPOSE: To provide a new compound having excellent insecticidal characteristics for armyworm, mite etc., useful as a pest controlling agent safely usable with assured effect. CONSTITUTION: The compound of formula I(X is halogen, alkyl, ...
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