| Document |
Document Title |
|
JP2007506729A |
This invention relates to prodrugs of certain amino acids that bind to the alpha-2-delta (alpha2delta) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of ...
|
|
JP2007502825A |
Novel PDF inhibitors and novel methods for their use are provided.
|
|
JP2006523213A |
Embodiments of this invention provide novel peptidomimetics that contain a macrocycle, an embodiment of which is 2S,9′S,12′S)-2-{[(1′,4′-Diaza-2′-oxobicyclo[7.3.0]
dodecyl)-12′-carbonyl]amino}-1,5-pentanedioic acid trifluoroa...
|
|
JP2006522156A |
The present invention relates to compounds of Formula (I): their pharmaceutical composition and their utility in treating neoplasm.
|
|
JP3782475B2 |
PURPOSE: To provide novel compounds having vasopressin and oxytocin antagonistic activity and useful in the treatment of diseases accompanied by excess water reabsorption by kidneys, diseases accompanied by increased vascular resistance ...
|
|
JP3660702B2 |
PURPOSE: To obtain a new heterocyclic compound containing nitrogen capable of irreversively generating red color by the irradiation of a light having a specific wave length, especially of an ultraviolet radiation, excellent in color stab...
|
|
JP3647451B2 |
A benzolactam derivative represented by the following formula (I): wherein n represents an integer of from 1 to 3; R<1> represents a straight- or branched-chain alkyl group or an aralkyl group; R<2> represents a straight- or branched-cha...
|
|
JP3630449B2 |
PURPOSE: To obtain a novel tricyclic compound which has antagonist activity at V1 and/or V2 receptors and exhibits in vivo vasopressin antagonist activity and is useful for treatment of diseases characterized by excess renal reabsorption...
|
|
JP2005015373A |
To provide a tetraazacyclodecahexaene compound suitably used for an optical memory, an optical switch, etc.The tetraazacyclodecahexaene compound is represented by formula (1) (wherein R1-R4 are identical to or different from each other a...
|
|
JP2004510775A |
There is provided a process for the preparation of a compound of formula I, (I), or a pharmaceutically acceptable derivative thereof, wherein A, B, G, R 1 , R 2 , R 3 , R 4 and R 41 to R 46 have meanings given in the description, which p...
|
|
JP3462234B2 |
PURPOSE: To obtain a new heterocyclic compound, having excellent choline esterase inhibiting activity and antidepressant action and useful as a therapeutic or a preventing agent for senile dementia. CONSTITUTION: The compound of formula ...
|
|
JP2003510251A |
Formulation components such as bleach boosting compounds selected from the group consisting of bleach boosters comprising quaternary imine cations, zwitterions, polyions having a net charge of from about +3 to about -3 and mixtures there...
|
|
JP2003506442A |
A compound of formula Iin which M, A1, A2, A3, A4, A5, A6, B1, B2, B3, B4, B5, B6, K1, and K2 are defined herein and are novel effective tryptase-inhibitors.
|
|
JP2002540197A |
Compounds of formula (I) are antibacterial agents wherein: R3 and R4, taken together with the carbon atoms to which they are respectively attached, form an optionally substituted saturated carbocyclic or heterocyclic ring of 5 to 16 atom...
|
|
JP2002504545A |
The subject invention involves processes for making 2-oxopiperazine and homologous compounds using a solid support resin by (a) removing the protecting group from an N-protected amino acid ester of the resin (if present), (b) reacting th...
|
|
JP2002502832A |
The present invention relates to methods for preparing macrocyclic products having 9 or more ring atoms by ring-closing diyne metathesis of suitable diyne substrates. The diyne substrates can be converted into cycloalkynes or into cycloa...
|
|
JP2001524949A |
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tis...
|
|
JP2001520215A |
The present invention relates to pharmaceutically acceptable compounds, including acylguanidine compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the inv...
|
|
JP3215338B2 |
To produce a new aminobenzenesulfonic acid derivative monohydrate useful for producing a medicinal composition effective in preventing or treating ischemic cardiopathy, cardiac failure and hypertension, etc. This new aminobenzenesulfonic...
|
|
JP3208140B2 |
A compound of formula or a pharmaceutically acceptable salt form thereof, is useful as a retrovial protease inhibitor for treating HIV infections.
|
|
JP2001509151A |
Macrocyclic compounds of formula (I) are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting comp...
|
|
JP2001172266A |
To provide a nitrogen-containing compound, to provide a complex formed from the nitrogen-containing compound and a transition metal in the group VIII, to provide a complex formed from the nitrogen-containing compound and zinc, and to pro...
|
|
JP2001506606A |
Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula:wherein X is O or NR<9 >and R<1>-R<4>, R<6>-R<9>, R<11>, R<12>, R, R, R, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or ...
|
|
JP3117717B2 |
PCT No. PCT/SE92/00690 Sec. 371 Date Apr. 1, 1994 Sec. 102(e) Date Apr. 1, 1994 PCT Filed Oct. 2, 1992 PCT Pub. No. WO93/07429 PCT Pub. Date Apr. 15, 1993.A foodstuff air treatment device includes a housing (1) with an elongated trough (...
|
|
JP2000510149A |
Compounds of formula (I) wherein R1 is H, (C1-C5)alkyl, OR, SR, N(R)(R), halo, NO2, NHC(O)[(C1-C4)alkyl] or NHOH; R2 is a (C5-C22) hydrocarbyl group, optionally comprising 1-3 double bonds, 1-2 triple bonds or a mixture thereof, or (C6-C...
|
|
JP3014146B2 |
The present invention provides an efficient process of reacting a bis-indolyl acid of the Formula (II): (II) wherein R1 is a hydrogen or C1-C4 alkyl and R, X, and Y are optional substitutions; to produce a bis-indolyloxallic acid of the ...
|
|
JP2000502050A |
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tis...
|
|
JP2945271B2 |
PURPOSE: To prepare an alkylimidazolidone(meth)acrylate under mild conditions by using a novel catalyst chosen from the chelates of calcium with 1,3-dicarbonyl compounds and reacting (meth)acrylate with heterocyclic alcohol. CONSTITUTION...
|
|
JP2905909B2 |
|
|
JP2895633B2 |
A compound (I) is prepared by reacting at least one (meth)acrylate (II) with a heterocyclic alcohol (III) in the presence of at least one catalyst chosen from tin dialkyloxides and/or tin dialkyldialkoxides. Alkylimidazolidone acryla...
|
|
JP2879918B2 |
The present invention is directed to a new class of cyclic guanidines of the formula: in which Q is represented by a substituent selected from the group consisting of (CH2)n in which n is an integer from 2-10, A is a substituent selected...
|
|
JPH11503132A |
A compound of formula (I), in which Z is selected from (a), (b), (c), (d), (e), (f), (g), (h), (i), (j) and (k). The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substitu...
|
|
JP2818640B2 |
PURPOSE: To obtain the subject compound for providing a catalyst exhibiting excellent productivity and selectivity at a lower temperature, by reacting (meth) acrylate and a heterocyclic alcohol in the presence of a magnesium alkoxide. CO...
|
|
JP2776782B2 |
Prepn. of N-alkyl-diazone methacrylate derivs. of formula (I) comprises reacting H2C=CR1-C(O)O-R2 with a heterocyclic alcohol of formula (III) in the presence of a catalyst comprising at least one magnesium alkoxide and calcium chelated ...
|
|
JPH107542A |
To obtain a skin lotion which has actions to prohibit the melanin formation and to inhibit the tyrosinase activity and is effective for prevention and improvement of pigmentation after sun burn, skin spots, freckles and liver spots. This...
|
|
JP2680044B2 |
|
|
JP2589702B2 |
A blood substitute employs combinations of fluoro or perfluorochemicals capable in the presence of emulsifying agents of forming emulsions stable at room temperature and possessing enhanced oxygen carrying capacity.
|
|
JPH08512313A |
PCT No. PCT/SE94/00664 Sec. 371 Date Jan. 30, 1995 Sec. 102(e) Date Jan. 30, 1995 PCT Filed Jul. 5, 1994 PCT Pub. No. WO95/01967 PCT Pub. Date Jan. 19, 1995Novel heterocyclic compounds having a structure according to general formula (1),...
|
|
JPH08509700A |
This invention relates to substituted cyclic carbonyls and derivatives thereof useful as Human Immunodeficiency Virus (HIV) protease inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these comp...
|
|
JPH08157453A |
PURPOSE: To obtain the subject composition reduced in the discoloration due to solar light, fluorescent lamp light, etc., and useful as a raw material for heat-resistant pigments, a heat-sensitive coloring agent, etc., by reducing a spec...
|
|
JPH08503693A |
PCT No. PCT/EP93/02306 Sec. 371 Date Feb. 15, 1995 Sec. 102(e) Date Feb. 15, 1995 PCT Filed Aug. 26, 1993 PCT Pub. No. WO94/05671 PCT Pub. Date Mar. 17, 1994The invention relates to an addition compound which is obtainable by reaction of...
|
|
JPH0859574A |
PURPOSE: To prepare a new compound which is an important intermediate for a bistertiary phosphine useful as a bidentate ligand of a complex used for a hydrogenating catalyst, etc. CONSTITUTION: This compound is represented by formula I (...
|
|
JPH07258224A |
PURPOSE: To provide a new bicyclic compound useful as a causal treatment antirheumatic agent for the prevention and treatment of autoimmune diseases and inflammatory diseases and exhibiting strong effect and high safety. CONSTITUTION: Th...
|
|
JPH07247273A |
PURPOSE: To obtain a new fullerene derivative useful as a physiologically active substance such as an anti-HIV active substance, and improved in hydrophilicity owing to adding pyrazoline ring thereto. CONSTITUTION: This new fullerene der...
|
|
JPH0776214B2 |
Novel benzoheterocyclic compounds of formula (I), wherein R<1> is H, halogen, alkyl, optionally substituted amino, alkoxy; R<2> is H, halogen, alkoxy, phenylalkoxy, OH, alkyl, optionally substituted amino, carbamoyl-alkoxy, optionally su...
|
|
JPH07206827A |
PURPOSE: To obtain a process for producing a cyclic amidine compound in high yield at a low cost. CONSTITUTION: This process for the production of a cyclic amidine compound by reacting a nitrile compound with a polyamino compound in liqu...
|
|
JPH07173142A |
PURPOSE: To obtain the subject novel inhibitor which inhibits the angiotensinogen-cleaving action of a natural proteolytic enzyme, renin, and is useful in treating or preventing renin-associated hypertension, hyperaldosteronism, glaucoma...
|
|
JPH0749421B2 |
Acrylates or methacrylates I I (A and B=C2-C5-alkylene, R1=H, CH3) are prepared by reacting an acrylate or methacrylate II II (R2=C1-C4-alkyl) with a heterocycle III III in the presence of titanium alcoholates chelate compounds of the me...
|
|
JPH07501057A |
PCT No. PCT/US92/09467 Sec. 371 Date Apr. 29, 1994 Sec. 102(e) Date Apr. 29, 1994 PCT Filed Oct. 30, 1992This invention relates to a method of inhibiting platelet aggregation using 1,4-diazocine compounds which are mimics of the peptide ...
|
|
JPH06507176A |
This invention concerns cyclic aromatic amide oligomer compositions and a process for preparing such cyclic oligomers.
|
