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WO/2018/071320A1 |
The (1R,3R)- or (1S,3S)-enantiomer of 2,2-dichloro-3-(substituted phenyl)cyclopropane-carboxylic acid is prepared in a process involving chemical resolution of a racemic mixture of a trans-2,2-dichloro-3-(substituted phenyl)cyclopropanec...
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WO/2018/066447A1 |
A method for producing 1, 4-dicyanocyclohexane, which comprises a step for obtaining 1, 4-dicyanocyclohexane by subjecting a thermal concentrate of an ammonia aqueous solution of 1, 4-cyclohexane dicarboxylic acid to a cyanation reaction.
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WO/2018/062854A1 |
The present invention relates to a method for producing 1,3-cyclohexanedicarboxylic acid, wherein the efficiency and economic feasibility of a reaction can be improved by using a catalyst which exhibits excellent activity and has improve...
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WO/2018/032796A1 |
Disclosed is a novel 2-fluorocyclopropane carboxylic acid synthesis method, comprising the following steps: 1) reacting 1,1-dichloro-1-fluoroethane with thiophenol in the presence of alkali to produce a phenyl sulfide intermediate; 2) ca...
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WO/2018/012425A1 |
Provided is a method for manufacturing carboxylic acid or a salt thereof under a moderate condition and in a simple, highly-selective, high-yielding manner. Provided is a method for manufacturing a compound represented by general formula...
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WO/2018/011226A1 |
The invention relates to chemical compositions in the form of an organogel, comprising a gelled organic liquid, comprising or consisting of a volatile organic liquid, and at least one resin acid. The invention also relates to a method fo...
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WO/2018/010932A1 |
The present invention relates to a method of reacting starting materials with an activating group, namely alkanes carrying a leaving group and/or olefins, with carbon dioxide under transition metal catalysis to give carboxyl group-contai...
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WO/2017/179727A1 |
The present invention is a radiation sensitive resin composition which contains a polymer having a first structural unit that contains an acid-cleavable group, a first radiation sensitive acid generator and a solvent, and wherein the fir...
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WO/2017/172957A1 |
Compounds of Formula (I) are estrogen receptor alpha modulators, where the variables in Formula (I) are described in the disclosure. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for tr...
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WO/2017/154947A1 |
In order to provide a high-purity 1,4-cyclohexanedicarboxylic acid powder having excellent powder flow properties, the present invention provides a high-purity 1,4-cyclohexanedicarboxylic acid powder in which: the grain size distribution...
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WO/2017/143946A1 |
Provided are a fatty acid compound, a preparation method therefor and use thereof. The fatty acid compound is of a structure represented by general formula I. The compound has an AMPK activating activity and a capability of inhibiting gl...
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WO/2017/136976A1 |
The present invention discloses an ionic liquid having a methanofullerene carboxylate as an anion, and a preparation method thereof. The ionic liquid is comprised of the methanofullerene carboxylate anion and a quaternary ammonium cation...
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WO/2017/130871A1 |
The present invention provides a method for producing an acid halide solution that is useful when producing a polymerizable liquid crystal compound. This method for producing an acid halide solution includes: a first step of obtaining a ...
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WO/2017/056501A1 |
The present invention provides a method for producing an acid halide solution, which is useful as a production intermediate or the like that enables a polymerizable liquid crystal compound to be produced in an industrially advantageous m...
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WO/2017/035271A1 |
The invention provides compounds having the general formula (I): (I) and pharmaceutically acceptable salts thereof, wherein the variables RAA, n, ring A, X1, L, m, X2, R2, R3, R4, R5, X, and R6 have the meaning as described herein, and c...
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WO/2017/019487A1 |
Provided herein are methods and intermediates for making (lR,2R,5R)-5-amino-2- methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated w...
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WO/2016/114707A1 |
The present invention relates to derivatives of dehydroabietic acid useful in treatment ofcardiac arrhythmiaor a hyperexcitablity disease, such as epilepsy or pain, by extracellularly acting on the voltage sensitive domain (VSD) to open ...
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WO/2016/079431A1 |
The invention relates to 2-octylcyclopropyl-1-carboxylic acid, especially in the form of one of the isomers thereof, which is isolated, or in the form of a mixture of at least two of said isomers. The invention also relates to a method f...
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WO/2016/071849A1 |
The present invention relates to a process for preparing Lomitapide or its pharmaceutically acceptable salt thereof having high purity with acceptable levels of impurities.
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WO/2016/038379A1 |
The invention relates to pharmaceutical uses of compounds of formula (II). Particular aspects of the invention relate to the use of those compounds in treating, preventing or ameliorating a seizure-related disorder, bipolar disorder, man...
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WO/2016/026014A1 |
The present invention provides a perillic acid derivative in the form of a salt having formula II, with anti-cancer activity, in which the counter-ion M+ comprises alkali or alkaline earth metals, such as Na+ (sodium), K+ (potassium), Ca...
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WO/2016/016641A1 |
A quaternary ammonium salt of formula wherein each of R1, R2, R3 and R4 is independently selected from an optionally substituted alkyl, alkenyl or aryl group having less than 8 carbon atoms and R5 is hydrogen or an optionally substituted...
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WO/2015/181094A1 |
The present invention relates to the therapeutic use of derivatives of 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid for improving the cognitive capacity of patients with intellectual disabilities, an IQ of less than 85, diagnose...
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WO/2015/170713A1 |
Provided is a method for producing a 1,3-di-substituted-cyclobutane-1,2,3,4-tetracarboxylic acid (2) and a dianhydride (3) of the acid with high selectivity and high yield. A 1,3-di-substituted-cyclobutane-1,2,3,4-tetracarboxylic acid (2...
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WO/2015/134710A1 |
Disclosed herein are compounds of the general Formula (I), and methods of synthesizing substituted bicyclo[1.1.1 jpentanes. The synthetic methods described herein use a [1.1.1]propellane, a Group VIII transition metal compound, a hydride...
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WO/2015/129740A1 |
The present invention provides a method for producing an alicyclic polycarboxylic acid capable of keeping the heat removal performance of a reaction mixture stable and obtaining stable reaction results over an extended period of time. In...
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WO/2015/108170A1 |
Provided is a method for obtaining cyclobutanetetracarboxylic acid and/or a dianhydride thereof by using, as the raw material, the residue remaining after a target substance generated in a process for producing a cyclobutanetetracarboxyl...
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WO/2015/012263A1 |
An adsorption method for saturated hydrocarbon that causes a saturated hydrocarbon having no more than three carbon atoms to be selectively absorbed by a metal complex including a ligand indicated by formula (1) and metal ion, by causing...
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WO/2014/205392A1 |
Disclosed herein are cocrystals of dimethyl fumarate and gentisic acid or (+)-camphoric acid. Dimethyl fumarate is a prodrug of methyl hydrogen fumarate. The cocrystals have improved physicochemical properties and are used in treating mu...
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WO/2014/129569A1 |
A method for producing a metal complex comprising a polycarboxylic acid compound, at least one metal ion, an organic ligand capable of multidentately coordinating with the metal ion and a monocarboxylic acid compound, wherein a metal sal...
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WO/2014/110388A1 |
Method to obtain methylene malonate and related monomers following a bis(hydroxymethyl) malonate pathway. A bis(hydroxymethyl) malonate intermediary is subsequently reacted (i.e., subjected to thermolysis) to provide a methylene malonate...
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WO/2014/110036A1 |
Compounds of formula (I): [Formula should be inserted here]; where [Formula should be inserted here], n, R1, R4a, R4b, R5, R7 and R8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed co...
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WO/2014/102808A1 |
A commercially viable process for industrial preparation of trans-(l R,2R)-cyclohexane 1,2- dicarboxylic acid represented by compound of Formula-I, wherein the compound has more than 99% HPLC purity. The compound of Formula-I is a key in...
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WO/2014/053618A1 |
The present invention relates to a method for producing at least one cyclohexanecarboxylic acid or a derivative thereof by bringing into contact at least one corresponding benzene polycarboxylic acid or a derivative thereof with a gas co...
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WO/2013/190357A1 |
The present invention provides an improved process for the preparation of a compound of formula (I),
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WO/2013/181786A1 |
Provided in the present invention are various labdane diterpenoid compounds and derivatives thereof for use in preparation of a pharmaceutical composition for preventing or treating neurodegenerative diseases. Also provided in the presen...
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WO/2013/180462A1 |
The present invention is related to the inventive compositions comprising the extract of pine leaf extract or the compound isolated therefrom. It showed potent inhibitory effect on human papillomavirus (HPV) as well as anti-cancer effect...
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WO/2013/169740A2 |
Synthetic triterpenoids and methods of using the same to induce gene expression and differentiation of stem or progenitor cells are provided.
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WO/2013/117687A1 |
The present invention pertains to a method for preparing a carboxylic acid by acidification of a liquid feed comprising a carboxylate salt, which method comprises the steps of - providing a liquid feed comprising magnesium carboxylate; -...
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WO/2013/086460A1 |
A photoacid compound comprising a light absorbing moiety attaching a payload moiety through a linker, in which the linker comprises a geminal dialkyl linked to a carbonyl group attaching the payload moiety, and the linker is configured t...
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WO/2013/078372A1 |
In an aspect, the invention relates to compositions, methods, and kits for inhibiting or preventing skeletal muscle atrophy or inducing muscle hypertrophy by providing to an animal an effective amount of a composition comprising a Gadd45...
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WO/2013/028289A1 |
Described herein are oxygen scavengers, oxygen scavenging polymeric compositions, and oxygen scavenging articles. The polymeric compositions comprising the oxygen scavengers may have utility in packaging, sealing, wrapping, and storing o...
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WO/2013/007712A1 |
A process for the preparation of a compound of formula (I): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
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WO/2012/117976A1 |
Provided are a method for producing an alicyclic carboxylic acid by hydrogenation of the aromatic ring of an aromatic carboxylic acid, wherein a catalyst containing ruthenium and palladium is used as the catalyst, and a catalyst supporti...
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WO/2012/116238A1 |
The present disclosure is directed to compositions and methods for formulating a pharmaceutical dosage form by forming a composition comprising acetyl-11-keto-β- boswellic acid, diindolylmethane, or curcumin with one or more pharmaceuti...
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WO/2012/086409A1 |
Disclosed is a mixture of regioisomers of dehydroabietic acid derivatives, which comprises at least two dehydroabietic acid derivatives each represented by general formula (I) and independently selected from the group consisting of methy...
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WO/2012/082727A1 |
The present invention relates to polyamides prepared from benzene, cyclohexene and cyclohexane compounds having amide groups at the 1 and 4 positions and optionally the 2 position and diamines, such as 1,2-ethylene diamine, 1,4-diaminobu...
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WO/2012/080647A2 |
The invention relates to a continuous method for the carbonylation of an (R1R3)C - X alcohol in acid, where: R1 and R3 are radicals bonded to the carbon atom by means of a single covalent bond, or an aliphatic cyclic compound that integr...
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WO/2012/060347A1 |
[Problem] To provide an environmentally friendly organic hybrid type catalyst for achieving oxidation reaction of alcohols. [Solution] An organic hybrid type catalyst which is a 2,2,6,6-tetramethylpyridine-1-oxyl derivative represented b...
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WO/2012/054400A1 |
A method is disclosed for the recovery of an organic acid from a dilute salt solution in which the cation of the salt forms an insoluble carbonate salt. An amine, C02 and a water immiscible solvent are introduced to the solution to form ...
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