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WO/2003/031401A1 |
A process for preparation of 19−norvitamin D derivatives represented by the general formula (3): (3) [wherein RA is hydrogen, halogeno, or the like&semi Z is C1−26 alkyl or the like&semi and X1 and X2 are each independently hydrogen,...
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WO/2003/027065A1 |
The present invention refers to compounds according to formula (I) or a salt thereof, where the dotted line, R?1¿, R?2¿, R?3¿, R?4¿ and L are defined in the claims. The invention further refers to the use of the compounds of formula ...
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WO/2002/094754A1 |
The invention concerns novel bi-aromatic compounds, analogues of Vitamin D. The invention also concerns a method for preparing same, and the use thereof in pharmaceutical compositions for use in human or veterinary medicine (in dermatolo...
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WO/2002/066424A1 |
A novel vitamin D derivative having a specific substituent incorporated in the 2-position. The vitamin D derivative is represented by the general formula (1): (1) (wherein A represents linear or branched lower alkyl optionally substitute...
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WO2001002352A9 |
A method of purifying 1 alpha ,24(S)-dihydroxyvitamin D2 to obtain 1 alpha ,24(S)-dihydroxyvitamin D2 in crystalline form. The method includes the steps of boiling a solvent under inert atmosphere, dissolving a product containing 1 alpha...
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WO/2002/020021A1 |
This invention discloses 1$g(a)-hydroxy-2-methylene-19-nor-homopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their diff...
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WO/2002/017911A1 |
Parathyroid hormone production inhibitors or remedies for parathyroid hyperfunction which contain as the active ingredient vitamin D¿3? derivatives represented by general formula (1) wherein m is an integer of from 1 to 3; q is an integ...
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WO/2002/014268A1 |
A vitamin D derivative which has a methyl group in the 1-position and has an epi form in the 20-position. The vitamin D derivative is represented by the general formula (1): wherein R represents linear or branched alkyl optionally substi...
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WO/2002/012182A1 |
3-Methyl-20-epi-vitamin D derivatives represented by the general formula (1), wherein R is straight-chain or branched alkyl which may be hydroxylated.
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WO/2002/005823A2 |
This invention provides pharmaceutical uses for 2-methylene-19-nor-20(S)-1$g(a),25-dihydroxyvitamin D¿3?. This compound is characterized by high bone calcium mobilization activity demonstrating preferential activity on bone. This result...
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WO/2002/005824A1 |
This invention provides pharmaceutical uses for 2$g(a)-methyl-19-nor-20(S)-1$g(a),25-dihydroxyvitamin D¿3?. This compounds is characterized by high bone calcium mobilization activity demonstrating preferential activity on bone. This res...
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WO/2002/006218A2 |
The invention provides a stabilized 1$g(a)-hydroxy vitamin D ('SHVD') which is particularly well suited for pharmaceutical formulations.
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WO/2002/000679A2 |
Compounds of formula (I), where R is a monovalent cyclic organic group having from 3 to 15 atoms in the ring system, useful as pharmaceuticals.
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WO/2001/096293A1 |
Provided are vitamin D derivatives which exhibit excellent physiologic activities suitable for drugs, particularly remedies for dermatoses such as psoriasis, and are lowered in the calcium increasing activity. The derivatives are represe...
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WO/2001/092221A1 |
Biologically active 19-nor vitamin D analogs substituted at C-2 in the A-ring with an ethylidene or an ethyl group. These compounds have preferential activity on mobilizing calcium from bone and either high or normal intestinal calcium t...
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WO/2001/090061A1 |
Novel vitamin D derivatives are synthesized which are 5,6-trans-2-alkylated-vitamin D derivatives represented by the general formula (1), wherein R¿1? is linear or branched alkyl; and R¿2? is optionally hydroxylated linear or branched ...
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WO/2001/079165A1 |
The invention relates to a novel synthesis intermediate product of formula (I), to the microbiological production thereof, and to its use for the synthesis of vitamin D derivatives.
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WO/2001/079166A1 |
The invention aims at providing vitamin D¿3? derivatives which exhibit excellent physiological activities for drugs including remedies for skin diseases such as psoriasis and lowered calcium-increasing activities. Specifically, vitamin ...
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WO/2001/074766A1 |
This invention provides a novel class of vitamin D related compounds, namely, the 2-alkylidene-19-nor-vitamin D derivatives, as well as a general method for their chemical synthesis. The compounds have formula (I), where Y¿1? and Y¿2?,...
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WO/2001/074765A1 |
This invention provides 2-alkyl-19-nor-vitamin D derivatives, as well as a general method for their chemical synthesis. The compounds have formula (I) where Y¿1? and Y¿2?, which may be the same or different, are each selected from the ...
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WO/2001/074764A1 |
Intermediates for the synthesis of 1$g(a)-hydroxyvitamin D derivatives useful as drugs; and processes for the preparation of the same. Specifically, a process for the preparation of a compound of the general formula (5), which comprises ...
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WO/2001/074506A1 |
An extrusion die comprises a die body defining a die cavity (18). The cavity (18) is shaped such that the die body includes a male portion (24) and a female portion (26). A leading edge (18a) of a part of one side of the die cavity (18) ...
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WO/2001/074840A2 |
The present invention relates, $i(inter alia), to compounds having the general formula (I) in which: R?1¿ is a member selected from the group consisting of -OCH¿3? -SCH¿3?, -N(CH¿3?)¿2?, -NHCH¿3?, -NC¿4?H¿8?, -NC¿5?H¿10?, -NC¿...
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WO/2001/062723A1 |
The invention aims at synthesizing novel vitamin D derivatives having substituents at the 2$g(a)-position. Vitamin D derivatives of the general formula (1) are provided wherein R¿1? and R¿2? are each straight-chain or branched lower al...
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WO/2001/056982A1 |
The invention relates to compounds of the formula (I) wherein R?1¿ et R?2¿, which may be the same or different, represent hydrogen or a residue after removal of 1 hydrogen atom from a straight, branched or cyclic, saturated or unsatura...
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WO/2001/056981A1 |
Compounds of the formula (I) wherein X represents hydrogen or hydroxy; Y represents oxygen or sulphur or oxidized sulphur selected from the groups S(O) and S(O¿2?); R?1¿ and R?2¿, which may be the same or different, represent hydrogen...
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WO/2001/055098A1 |
The present invention is directed to a compound having the structure (I): and acceptable salts, polypeptides, and pro-forms thereof, wherein R is selected from the group consisting of: (a) substituted glycerols; wherein n is an integer f...
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WO/2001/051464A1 |
Compounds of the formula (I) wherein X represents hydrogen or hydroxy; R?1¿ and R?2¿, which may be the same or different, represent hydrogen, (C¿1?-C¿4?)alkyl optionally substituted with one hydroxyl group or one or more fluorine ato...
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WO/2001/046131A1 |
The invention provides a method for making 24(S)-hydroxyvitamin D¿2? which is a stereospecific synthesis.
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WO/2001/046132A1 |
Methods of treating inflammatory bowel disease are described, and in particular the prevention and treatment of inflammatory bowel disease in humans as well as other animals. These methods involve the administration of biologically activ...
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WO/2001/042205A2 |
A method of treating inflammatory bowel disease, particularly ulcerative colitis and Crohn's disease, is disclosed. The method involves administering a vitamin D compound in an amount effective to treat the disease. The administration of...
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WO/2001/042251A1 |
The invention relates to precursors of the A-ring of vitamin D, of formula (I): in which A, R, R¿1? and R¿2? are as defined in the specification. The invention also relates to a method of preparing compounds (I) comprising the enzymati...
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WO/2001/040177A2 |
Analogs of vitamin D¿3?, in particular esters of vitamin D¿3? and uses thereof, are described. The compounds of the present invention can be used as substitutes for natural and synthetic vitamin D¿3? compounds.
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WO/2001/030751A2 |
1,25-dihydroxy-5,6-trans vitamin D compounds and their derivatives, especially the esters, are useful in the treatment or prevention of diseases characterised by abnormall cell differentiation or cell proliferation, as well as other dise...
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WO/2001/016099A1 |
Novel vitamin D¿3? derivatives having substituents at the 2$g(a)-position, which are represented by general formula (I), wherein R?1¿ is a saturated aliphatic C¿1?-C¿15? hydrocarbon group which may be substituted with one to three op...
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WO/2001/010829A1 |
The present invention relates to compounds of formula (I), in which formula R represents hydrogen, or R represents (C¿1?-C¿6?)alkyl, phenyl, or (C¿7?-C¿9?)aralkyl, optionally substituted with one or more groups selected from (C¿1?-C...
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WO/2001/007405A2 |
The invention relates to vitamin D derivatives of the formula (I), wherein Z is an optionally substituted carbocyclic or heterocyclic, optionally aromatic or heteroaromatic 5- or 6-membered ring or an optionally substituted condensed rin...
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WO/2001/004089A1 |
Compounds of formula (I) wherein R¿1? is hydrogen or an alkyl group; R¿2? is hydrogen or an alkyl group; or R¿1?, R¿2? and C¿20? together are cyclopropyl; A is a, b, c or d; R¿3? is alkyl, hydroxy-alkyl or fluoroalkyl; and R¿4? is...
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WO/2000/066548A1 |
Novel vitamin D¿3? derivatives which are substituted at the 2-position and epimerized at the 20-position and have -O- or -CH(CH¿3?)- at the 22-position, as represented by general formula (I): wherein X is -O- or -CH(CH¿3?)-; R?1¿ is ...
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WO/2000/064870A1 |
Novel 3-methylated vitamin D¿3? derivatives represented by general formula (I) wherein X is -CH¿2?-, -O-, or -S-; and R?1¿ is a C¿1?-C¿15? saturated or unsaturated aliphatic hydrocarbon group which may be substituted with one to thr...
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WO/2000/064924A1 |
A method for separating sterols from neutral substances comprising the sterols, the method comprising: (a) providing a hydrocarbon fraction containing in the neutral substances; (b) optionally washing the hydrocarbon fraction with water;...
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WO/2000/064869A1 |
The present invention relates to compounds of general formula (I) wherein R?1¿ and R?2¿, which may be the same or different, represent (C¿1?-C¿4?)alkyl, and R?3¿ represents hydrogen, halogen, (C¿1?-C¿4?)alkyl, or O-(C¿1?-C¿4?)al...
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WO/2000/061694A1 |
The present invention provides a method for manufacturing fat-soluble phytosterol or phytostanol ester of unsaturated fatty acid for inhibiting the absorption of cholesterol and foodstuffs containing the same. The method for manufacturin...
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WO/2000/061549A2 |
Compounds or their salts of general formula (I): A-(B) wherein A = R-T¿1?-, wherein R is the drug radical and T¿1? = (CO)¿t? or (X)¿t'?, wherein X = O, S, NR¿1C?, R¿1C? is H or an alkyl having from 1 to 5 carbon atoms, or a free va...
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WO/2000/059513A1 |
Novel sulfur-containing analogs of 1$g(a),25- dihydroxyvitamin D¿3? are provided. These analogs are synthesized in a convergent manner by joining A-ring and C,D ring fragments. Each analog with 1$g(a),3$g(b)-substituent stereochemistry ...
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WO/2000/043361A1 |
A method of purifying 1$g(a)-hydroxyvitamin D¿2? to obtain 1$g(a)-hydroxyvitamin D¿2? in crystalline form. The method includes the steps of boiling a solvent selected from the group consisting of ethyl formate, ethyl acetate and a 2-pr...
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WO/2000/042008A1 |
The invention relates to a group of new vitamin D analogs of formula (I), wherein R¿1? is a hydrogen atom or a hydroxy group, A and B represent hydrogen or methyl, or together form the methylene group, R¿2? is a group of formula (II), ...
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WO/2000/024712A1 |
Compounds represented by general formula (1), wherein R¿01? and R¿02? are each independently hydrogen or a hydroxyl-protecting group; and Z is a group represented by general formula (1-1), (1-2), (1-3), (1-4) or (1-5). These compounds ...
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WO/2000/010548A2 |
The 26 and/or 27 homologated analogs of 19-nor-1$g(a),25-dihydroxyvitamin D¿3? are disclosed as having relatively high calcemic activity. The 26 and/or 27 homologated analogs showed strong in vivo calcium transport as well as bone calci...
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WO/2000/001477A1 |
An ultraviolet irradiation apparatus for a photochemical reaction which can irradiate an ultraviolet ray of a specific wavelength suitable to a desired photochemical reaction to a photochemical reaction mixture as well as a method for pr...
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