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WO/2016/062212A1 |
The present invention provides a method for recycling 3-carbamoymethyl-5-methylhexanoic acid from a 3-carbamoymethyl-5-methylhexanoic acid chiral resolution mother liquor. The method comprises the following steps: (a) distilling the 3-ca...
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WO/2016/056533A1 |
The present invention provides a method for producing an aqueous solution including bis(Nε-lauroyllysine)dicarboxylic acid diamide and/or a salt thereof and having a pH of 9-11, the method including a first step for forming bis(Nε-laur...
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WO/2016/057771A1 |
The present disclosure describes a method of coupling a first compound to a second compound, the method comprising: providing the first compound having a fluorosulfonate substituent; providing the second compound comprising an alkene; an...
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WO/2016/057770A1 |
The present disclosure describes a method of coupling a first compound to a second compound, the method comprising: providing the first compound having a fluorosulfonate substituent; providing the second compound comprising an amine; and...
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WO/2016/050894A1 |
The invention relates to a method for the manufacture of N,N-dialkyllactamide, whereby at least one of the compounds selected from the series consisting of alkyl lactate, lactide and polylactic acid is mixed with dialkylamine in order to...
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WO/2016/052928A1 |
The present invention relates to an alpha-aminoamide derivative compound and a pharmaceutical composition comprising the same. According to various embodiments of the present invention, provided is a therapeutic agent which can overcome ...
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WO/2016/053212A1 |
The present invention relates to a process for the preparation of gelling free, flowable and pumpable aqueous betaine solution with a betaine content of < %32 having the general formula (I), in which R is a mixture of C8-C18 alkyl and C8...
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WO/2016/046833A2 |
Provided herein are improved, commercially viable and industrially advantageous processes for the preparation of Agomelatine, in high yield and purity, using novel intermediates.
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WO/2016/046398A1 |
The present invention relates to a novel chiral synthesis of N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]tr
iazolo[4,3-a]pyrazines of Formula (I), avoiding the use of protection/deprotection steps.
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WO/2016/038543A1 |
The invention describes phospho-amino pincer-type ligands, metal complexes thereof, and catalytic methods comprising such metal complexes for conversion of carbon dioxide to methanol, conversion of aldehydes into alcohols, conversion of ...
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WO/2016/039393A1 |
The purpose of the present invention is to provide a method for high-yield, inexpensive, and safe industrial production of a lacosamide having high optical purity. The present invention addresses said issue by providing a method for high...
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WO/2016/034327A1 |
Novel 2,2'-diamino biaryls of formula (I), (II) and (III), wherein R1-R10, R1'-R10', X1 - X3 and X1-X3' are defined in claim 1. The invention also relates to an electrochemical method for the production thereof.
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WO/2016/034330A1 |
Novel 2,2'-diamino biaryls of formula (I), (II) and (III), wherein R1-R10, R1'-R10' and X1-X3 are defined in claim 1. The invention also relates to an electrochemical method for the production thereof.
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WO/2016/034126A1 |
A compound of formula (I) is disclosed, which has a low toxicity, can significantly inhibit the migration and invasion of tumor cells in vitro, and can inhibit tumor metastasis in vivo in mice at low concentration, while showing notable ...
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WO/2016/035080A1 |
The present invention relates to novel Ruthenium complexes of formulae A1-A4 and their use, inter alia, for (1) dehydrogenative coupling of alcohols to esters; (2) hydrogenation of esters to alcohols (including hydrogenation of cyclic es...
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WO/2016/034328A1 |
The invention relates to novel 2,2'-diamino biaryls of formula (I), (IIa), (IIb) and (III), wherein R1-R10, R1'-R10' and X1-X3 are defined in claim 1. The invention also relates to an electrochemical method for the production thereof.
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WO/2016/032911A1 |
The present invention is directed to a process of making alkanolamides wherein the "aging" time is reduced and the diethanol amide to ester ratio in the finished product is increased. Further provided is an additive composition comprisin...
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WO/2016/030329A1 |
Novel efficient, time-saving and reliable radiofluorination procedures for the production of 18F-labelled active esters via nucleophilic substitution of the corresponding onium precursors with 18F- are described. The active ester includi...
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WO/2016/030911A2 |
An improved, cost effective process for the preparation of Lacosamide is disclosed. A novel intermediate of formula (IV) and a process for preparation of the novel intermediate is also disclosed. wherein, X is halogen.
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WO/2016/021711A1 |
The present invention addresses the problem of providing a method for inexpensively, stably and industrially producing, at high yields, lacosamide having high optical purity. The abovementioned problem is solved by providing a method for...
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WO/2016/018553A1 |
Cure accelerators for anaerobic curable compositions, such as adhesives and sealants, are provided, and which are defined with reference to the aromatic amides shown in structure I where R and R" are each independently C1-10 alkyl, and R...
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WO/2016/017713A1 |
Provided is an oil and water separation device that can easily and inexpensively separate and collect the oil component from a mixed fluid comprising water and oil. This oil and water separation device gravity-filters a mixed fluid compr...
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WO/2016/017754A1 |
This filter medium for separating a liquid containing water and oil and having a channel for the liquid also has a substrate constituting the channel, and one or more types of nitrogen-containing fluorine-based compounds present on the s...
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WO/2016/017768A1 |
This hydrophilic oil-repellent complex includes one or more types of nitrogen-containing fluorine compounds, and an inorganic compound that has an electric charge or ionic group. The nitrogen-containing fluorine compound includes, within...
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WO/2016/017686A1 |
This hydrophilic oil repellent agent includes at least one species of nitrogen-containing fluorine compound. The nitrogen-containing fluorine compound includes, in the molecule thereof, any one hydrophilicity-imparting group selected fro...
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WO/2016/013033A1 |
The present invention discloses a novel vinylic 3-amino-1,2 diol compounds of formula (I) and a one pot cost-effective process for the synthesis of vinylic-3-amino-1,2-diols of formula (I) which comprises tandem α-amination-benzoyloxyal...
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WO/2016/013032A1 |
The present invention discloses tricyclic compounds of formula (I) or salt thereof and their process for synthesis. Further, the present invention relates to the use of these novel tricyclic compounds of formula (I) or salt thereof as in...
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WO/2016/005407A1 |
The present invention refers to the first one-pot synthesis of squaramides. The one-pot synthesis of squaramides described herein is an easy and straightforward procedure to obtain squaramide derivatives which saves energy, avoids time c...
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WO/2016/003161A1 |
The present invention provides a preparation method capable of commercially mass-producing agomelatine-resorcinol and agomelatine-hydroquinone cocrystals by using a solvent-antisolvent method. The cocrystals prepared by the preparation m...
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WO/2015/193911A1 |
The present invention relates to a process for the preparation of 2-(trihalomethyl) benzamide from a 2-(trihalomethyl) benzoyl chloride in the presence of isopropanol or cold water.
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WO/2015/192282A1 |
The present invention mainly pertains to a catalytic process for preparing a formamide,comprising reacting a formic acid ester with an aromatic amine carrying at least one electron withdrawing group in the presence of a catalyst of fluor...
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WO/2015/165352A1 |
The present invention provides a compound with a structure represented by general formula I or a pharmaceutically acceptable salt thereof, a preparation method for the compound or the salt, and a use of the compound or the pharmaceutical...
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WO/2015/162144A1 |
The invention relates to a novel method for producing substituted biphenylamides of general formula (V), characterized in that anilides of formula (II) are reacted in a solvent which is different from tetrahydrofuran, having an organobor...
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WO/2015/156251A1 |
The present invention pertains to a method for producing a vinyl-amine-unit-containing polymer, the method having a step for preparing a mixture for polymerization (a) that contains N-vinylformamide as a monomer component by using crude ...
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WO/2015/156346A1 |
Provided is a method for producing a synthetic intermediate of a heterocyclic compound having a renin inhibitory activity and effective as a prophylactic or therapeutic drug against diabetic renal disease, hypertension, and the like. A m...
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WO/2015/144902A1 |
The present invention relates generally to an eco-friendly methodology for the conversion of alcohols and aldehydes to amines and amides using an integrated enzyme cascade system with metal-and organocatalysis. More specifically, the pre...
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WO/2015/140057A1 |
The invention relates to a method for separating ammonia out of an alcoholic solution in the presence of carbonic acid compounds while avoiding formation of deposits, in that the solution to be separated is charged in the upper part of a...
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WO/2015/141585A1 |
Provided are an oligoaniline derivative represented by formula (1), a charge-transporting varnish comprising the oligoaniline derivative, and an organic EL element. (In the formula, R1 is a hydrogen atom or optionally substituted alkyl g...
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WO/2015/129813A1 |
The present invention provides: a deuteration method that is both cost effective and has an excellent deuteration rate; a method for selectively replacing a leaving group of an aromatic compound with deuterium; and a deuteration catalyst...
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WO/2015/121357A1 |
The invention relates to a method for hydrogenating carbon dioxide into a formamide, comprising the following steps: providing an organic phase, comprising an organic solvent and a catalyst dissolved or suspended in the organic solvent, ...
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WO/2015/122470A1 |
The present invention provides a well-balanced resist and compound for said resist with which sensitivity, resolution and line edge roughness (LER) can be improved without compromising basic physical properties as a chemically amplifying...
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WO/2015/109979A1 |
The present invention relates to a royal jelly acid derivative, which is characterized in that a chemical formula structure of the royal jelly acid derivative is (I). A beneficial effect of the present invention is: royal jelly acid is u...
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WO/2015/103901A1 |
Disclosed is a stearoyl amino acid salt. The stearoyl amino acid salt has a structural formula represented by a general formula (I), R1 indicating H or an aromatic base capable of substituted by one or more substituents, or C1-4 straight...
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WO/2015/086428A1 |
An effective process of making adamantanamide, which process is fast, does not the use of organic solvents or labor-intensive isolation or purification of the product, by removal of organic solvent or by-products, and has improved yield ...
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WO/2015/082719A1 |
An alternative acetylation process for the synthesis of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisoph
thalamide ("Compound A"), an intermediate in the industrial preparation of non-ionic X-ray contrast agents, is described...
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WO/2015/082718A1 |
Alternative continuous downstream processes for the production of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisoph
thalamide ("Compound A") are described. Compound A is a key intermediate in the production of iodixanol and io...
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WO/2015/082847A1 |
The invention relates to a method for the industrial synthesis of the compound of formula (I).
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WO/2015/082720A1 |
Alternative continuous downstream processes for the production of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisoph
thalamide ("Compound A") are described. Compound A is a key intermediate in the production of iodixanol and io...
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WO/2015/076296A1 |
The present invention relates to: a bromine-containing N-phenyldi(meth)acrylimide derivative represented by general formula (1) (wherein R1, R2, m and k are as described in the description and claims), which is useful as a reactive flame...
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WO/2015/074750A1 |
The invention relates to a partially crystalline N-alkyl-N-acylglucamine composition comprising at least two different acylglucamines with acyl groups selected from among saturated or unsaturated C6-C22 acyls, the composition having a pa...
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