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WO/2022/169363A1 |
The invention provides a method for the extraction of an organic acid (10) from a mixture (110), the method comprising: an extraction stage comprising providing the mixture (110) to a sorbent (150); an elution stage comprising passing an...
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WO/2022/167246A1 |
The present invention relates to soluble chelator-compounds, methods for their production and their use for the modification and/or immobilization of target molecules.
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WO/2022/152588A1 |
The present invention is directed towards a process for the synthesis of compounds with general formula (II) or their respective alkali metal salts by oxidation of compounds of general formula (I) with oxygen in the presence of a heterog...
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WO/2022/153187A1 |
Methods for producing a compound of Formula I, Formula I, wherein R1 and R2 are independently a i) linear or branched or cyclic, ii) saturated or unsaturated, and iii) substituted or unsubstituted hydrocarbon group comprising 8 to 20 car...
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WO/2022/152705A1 |
Compounds of Formula (I) wherein R1, R3, R11, R12, X, Y1, Y2, Y3, Y4 and formula (II) are as defined in the description. Medicaments.
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WO/2022/153962A1 |
The problem to be solved by the present invention is to provide: a compound useful as a hole transport material for photoelectric conversion elements whereby electric current can be efficiently taken out; and a photoelectric conversion e...
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WO/2022/152109A2 |
Provided herein are lipid compounds that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nuc...
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WO/2022/153003A1 |
The present invention relates to the field of perfumes and flavourings. More particularly, it relates to valencene derivatives and the use thereof as a perfuming or flavouring agent. It also relates to a perfuming or flavouring compositi...
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WO/2022/151995A1 |
Disclosed are a new crystal form of γ-aminobutyric acid and a preparation method therefor. The X-ray powder diffraction pattern of the crystal form has characteristic absorption peaks at diffraction angles 2θ of at least 22.3º ± 0.5Â...
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WO/2022/150927A1 |
The present disclosure is generally directed to a delivery device for the automatic injection of at least two doses of a fluid into the IM site of a subject during at least two different stages of operation. The delivery device generally...
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WO/2022/148456A1 |
Pharmaceutical compositions comprising a chemotherapeutic agent based on a β-substituted β-amino acid derivative are disclosed. The pharmaceutical compositions include a β-substituted β-amino acid derivative and a cyclodextrin deriva...
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WO/2022/136300A1 |
The present invention relates to the field of chemical manufacture. In particular, it relates to a method for manufacturing racemic methylglycinediacetic acid (MGDA) comprising the steps of contacting a solution comprising or being enric...
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WO/2022/134297A1 |
The present invention relates to a preparation method for a carboxylate ester compound, comprising: under the catalysis of a nitrite ester, reacting carboxylic acid and methanol in air, so as to obtain an ester compound. The preparation ...
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WO/2022/128692A1 |
Process for making a solid alkali metal salt (A) of an aminocarboxylate complexing agent, said process comprising the steps of(a) providing a 40 to 80% by weight aqueous solution or slurry comprising salt (A),(b) optionally, heating said...
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WO/2022/127153A1 |
Disclosed is a kettle-type continuous production method for glycine. The method comprises: carrying out hydantoin synthesis and hydrolysis reaction on glycolonitrile and ammonium carbonate, ammonium bicarbonate and water in a reactor wit...
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WO/2022/129020A1 |
The invention pertains to a process for manufacturing a nitrile compound through chain elongation of an alkylene amine compound containing three or more amine units in which at least two amine units are protected by a cyclic urea unit an...
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WO/2022/129284A1 |
The presently claimed invention relates to a method for obtaining crystalline diethylamino hydroxybenzoyl hexyl benzoate. Further, the presently claimed invention relates to crystalline diethylamino hydroxybenzoyl hexyl benzoate obtained...
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WO/2022/121854A1 |
The present invention relates to the technical field of pharmaceutical crystal forms, and specifically relates to 2-hydroxy-5-[2-(4-(trifluoromethylphenyl)ethylamino)]benzoic
acid crystal forms and a preparation method therefor. Crystal...
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WO/2022/121853A1 |
The present invention relates to the technical field of drug synthesis methods, and relates to a method for preparing 2-hydroxy-5-[2-(4-(trifluoromethylphenyl)ethylamino)]benzoic
acid. The method comprises steps such as protection, cond...
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WO/2022/121615A1 |
A method for preparing apalutamide. The method comprises the following steps: (a) in a solvent and optionally in the presence of a base, reacting a compound of formula A or a salt thereof with a compound of formula II, to obtain a compou...
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WO/2022/116338A1 |
The present application discloses a compound having vertical alignment properties, a liquid crystal display panel and a manufacturing method thereof. In the liquid crystal display panel of the present application, liquid crystal material...
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WO/2022/114135A1 |
Provided are: a crystal form that is stable in a use environment where a prodrug compound of an amino acid derivative exhibiting group 2 metabotropic glutamate receptor antagonism is used as a pharmaceutical product; and a method for pro...
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WO/2022/112855A1 |
A lipid compound of formula (I), including lipid nanoparticles thereof, and the manufacturing method and the use of pharmaceutical delivery are provided. The lipid compounds have formula (I): or a salt or an isomer thereof, wherein R1, R...
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WO/2022/114138A1 |
Provided is a novel method for producing a (1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(4-fluorophenyl)methoxy
]bicycle[3.1.0]hexane-2,6-dicarboxylic acid. This production method is characterized by relying on the conversion from a compound rep...
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WO/2022/106255A1 |
The present invention relates to a process for producing L-phenylalanine ester which comprises the reaction of L-phenylalanine with an alcohol in the presence of thionyl chloride.
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WO/2022/084834A1 |
The present invention concerns a novel process for preparing solriamfetol hydrochloride.
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WO/2022/082859A1 |
Provided is a refining method for an amino acid or derivatives thereof, comprising: (1) preparing a saturated aqueous solution of an amino acid or derivatives thereof from a crude product of the amino acid or derivatives thereof at prese...
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WO/2022/079394A1 |
The present invention relates to the sugar industry and concerns, in particular, a method for preparing a fermented molasses comprising at least one glycine betaine ester, said method comprising the steps of (1) providing a fermented bee...
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WO/2022/081750A1 |
The invention encompasses novel ionizable lipids compounds and their use in lipid nanoparticles delivery systems that are useful in the delivery of nucleic acids to a mammalian subject that can be included for use, for example, as cancer...
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WO/2022/076507A1 |
The present disclosure relates to compounds that are capable of inhibiting PRMT8 and/or upregulating SirTl. The disclosure further relates to methods of treating neurodegenerative diseases and disorders (e.g., Alzheimer's disease).
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WO/2022/075645A1 |
The present invention relates to: an aminoalcohol derivative; and a pharmaceutical composition for preventing or treating hypercholesteremia, containing same as an active ingredient, and a compound, a solvate thereof, a hydrate thereof o...
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WO/2022/061461A1 |
Disclosed herein are methods, processes and compositions for preparing a compound of formula 8: (8), and formula 18: (18). The methods and processes comprise performing a first allylic oxidation, a protection reaction, a second allylic o...
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WO/2022/064454A1 |
The present invention discloses a process for the synthesis of compound of formula (VII) or a salt thereof, wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The process further comprises the synthesis of an...
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WO/2022/064490A1 |
The present invention relates to novel herbicidally active compounds, agrochemical composition thereof, methods of preparation thereof, and uses thereof for controlling the growth of undesirable plants (e.g., weeds), for example in crop ...
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WO/2022/058916A1 |
The present invention disclosed a process for the synthesis of compound of formula (Z) or a salt thereof, wherein, R, R1, R2, R3 and R10 are as defined in the detailed description. The process further comprises the synthesis of an anthra...
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WO/2022/058733A1 |
The present invention relates to compounds for stabilising the native tetrameric form of transthyretin and protecting it from proteolytic cleavage; compounds for use in the prevention and treatment of transthyretin amyloidosis; and agent...
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WO/2022/054821A1 |
The present invention relates to a specimen extract or a specimen extraction method that includes a component capable of suppressing a false negative reaction which could not be suppressed by conventional methods, when detecting an antig...
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WO/2022/052926A1 |
An aromatic ethylene compound and preparation method therefor, and intermediate, pharmaceutical composition, and application thereof. The aromatic ethylene compound is represented by formula I-0. The aromatic ethylene compound has a sign...
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WO/2022/051979A1 |
A method for synthesizing a key intermediate compound 1 of fexuprazan, which is a potassium ion competitive blocker. The method comprises using 2,4-difluorobenzylamine as a raw material, and sequentially conducting condensation reaction,...
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WO/2022/056366A1 |
Compositions comprising at least one dialkyl amino acid ester salt as a cationic active are disclosed. The compositions are useful for hair care, as well as in other applications, such as cleaning compositions, fabric softening compositi...
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WO/2022/051804A1 |
Compounds of Formula (A) and methods for use as agricultural chemicals, including herbicides. Formula (A)
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WO/2022/049265A1 |
The presented invention relates to a process for preparation of Apalutamide, compound (1) (Formula 1) or a salt or a solvate thereof: The presented invention further relates to solid forms of Apalutamide, solvates of Apalutamide and to p...
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WO/2022/045231A1 |
This ester compound is represented by formula (1) [wherein R1 to R24 are each independently a hydrogen atom, a halogen atom, a hydrocarbon group, or a heteroatom-containing hydrocarbon group; R1 to R10, R23, and R24 may be bonded to each...
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WO/2022/040773A1 |
The present disclosure relates to compositions comprising an oil-in-water nano-emulsion dispersed in an external oil phase, methods for the preparation of such compositions as well as uses of such compositions, for example, for delivery ...
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WO/2022/037465A1 |
The present invention relates to a lipid nanoparticle. The lipid nanoparticle is formed by a compound of the following structure (I) or pharmaceutically acceptable salt, tautomer or stereisomer thereof. The present invention also provide...
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WO/2022/038477A1 |
The object of the invention concerns a quaternary ammonium salt of formula (I) wherein the substituents R5, R6 are independently chosen between hydrogen H and a radical R0, wherein the radical R0 consists of the structure of formula (II)...
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WO/2022/035228A1 |
The present application relates to: an amino acid extraction process for simultaneously performing racemization and enantioselective liquid-liquid extraction of amino acids in an aqueous solution by using a t-butyl ketone binaphthol deri...
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WO/2022/033303A1 |
The present invention relates to a benzylamine derivative, a preparation method therefor and use thereof, and in particular, to a benzylamine derivative as represented by general formula (I), or a pharmaceutically acceptable stereoisomer...
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WO/2022/028557A1 |
A 18F-labeled biphenyl compound, an intermediate thereof, a preparation method therefor, a pharmaceutical composition thereof, and application thereof. The biphenyl compound has a significant suppression effect on PD-1 and/or PD-L1, can ...
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WO/2022/027122A1 |
The present invention is related to compositions containing only natural products for the treatment of erectile and sexual dysfunction (ESD). More specifically relates to compositions containing Cannabis extract, and other herbal extract...
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