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JP6225358B2 |
The present invention provides a method for producing a benzaldehyde in which an amino group is bonded in the 2 position, a halogeno group or an alkoxy group is bonded in the 3 position, and a hydrogen atom, an alkyl group, a halogeno gr...
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JP2017531635A |
The present disclosure describes a method of coupling a first compound to a second compound, wherein the method provides a first compound having a fluorosulfonic acid substituent and a second compound containing an amine. The first compo...
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JP6219681B2 |
A method for making fluoroacyl arylamines is disclosed.
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JP6212056B2 |
The present invention pertains to novel enaminoketones containing a CF 3 O-group, novel pyrazole-derivatives containing a CF 3 O group as well as to a novel process for their preparation comprising aminoformylation of CF 3 O-ketones and ...
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JP6209125B2 |
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JP6185020B2 |
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JP6147345B2 |
Disclosed is a novel process for the reduction of nitro groups to amino derivatives, based on the use of trichlorosilane and an organic base, which is efficient from the chemical standpoint and of wide general applicability.
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JP2016204334A |
To provide a quantitative analysis method of (aminomethyl)aryl alkali metal salt capable of sampling collecting a part in a reaction and quantitatively analyzing it.Purity of aminomethyl aryl alkali metal salt (1) is measured by quantita...
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JP6033767B2 |
According to the invention there is provided a compound of Formula (I) in which: A is a C 2-8 alkylene group; R 1 , R 2 , R 3 , and R 4 are independently selected from hydrogen, C 1-4 alkyl, C 2-4 dihydroxyalkyl in which the carbon atom ...
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JP2016108332A |
To provide a method for producing an amino compound by reduction reaction of an azide compound with high yields, by a method showing consideration for the environment, conveniently and efficiently.The present invention provides a method ...
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JP5930975B2 |
A process is described for the preparation of 3-(5-formyl-2-hydroxyphenyl)-3-phenylpropylamine derivatives, intermediates which can be used for preparation of agents for urinary incontinence therapy, specifically to 2-(3-(diisopropylamin...
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JP2016510320A |
Equation (I):Compounds or pharmaceutically acceptable salts thereof are described herein. In equation (I), N, R1, R4a, R4b, R5, R7And R8Is as defined herein. The compounds of the present disclosure have activity as SHIP1 modulators and c...
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JP5854345B2 |
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JP2016501869A |
In the present invention, α- (3,5-dimethoxybenzylidene) -α'-hydrogen group methylene cyclic ketone having the composition of formula (I) or (II) (where R is an aryl group or an alkyl group) As a method for producing the same, cyclic ke...
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JP2015209402A |
To provide an alicyclic amine compound capable of being used as an intermediate of medicine, an intermediate material for industrial products, and an additive; and to provide a method for producing the same.This invention relates to: an ...
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JP5786621B2 |
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JP5782331B2 |
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JP5763599B2 |
The Invention relates to novel ketones of formulae (I) and (II) wherein R1, R2, R3 and R4 are, for example, C1-C8alkyl, R5 is, for example, hydrogen, A is CI, Br, -0-R7, -NR8R9 or -S-R16, A' is -O-, -NH- or -NR8-, X and Y are each indepe...
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JP5758844B2 |
One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and car...
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JP5725299B2 |
1,4 naphthoquinones derivatives, of formula (I) wherein A is selected from the following rings: their preparation and their application as antimalarial agents
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JP5701832B2 |
The present invention provides a method represented by Scheme 1: wherein X represents I, Br, Cl, alkylsulfonate, or arylsulfonate; Z represents optionally substituted aryl, heteroaryl or alkenyl; L represents hydrogen or a negative charg...
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JP2015501316A |
The present invention provides compounds useful for the treatment of hepatitis C virus (HCV) infections. This compound has the formula (1) [formulation] or a salt thereof, an N-oxide, a metamutant or a steric isomer, in which A is CH or ...
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JP5650530B2 |
Aldehyde compounds (I) are new. Aldehyde compounds of formula (O=CH-C(R 1>)(R 2>)-CH(R 3>)-N(R 4>)(R 5>)) (I) are new. Either R 1>, R 2>an univalent 1-12C-hydrocarbon; or R 1>R 2>a bivalent 4-12C hydrocarbon (whose one part is optionally...
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JP2014210715A |
To provide a new hydrophilic and neutral compound having ultraviolet A wave (UVA) absorbing properties and a method for producing the same, and to provide an ultraviolet absorber and a skin external preparation using the same.There is pr...
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JP5599974B2 |
The present invention relates to processes for the preparation of 4-hydroxy-±'-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-b
enzenedimethanol 1-hydroxy-2-naphthoate (salmeterol xinafoate) (12a), the preparation of 4-hydroxy-±'-[[[6-(4...
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JP2014172847A |
To provide an industrially advantageous method for producing a corresponding aromatic amine compound from an aromatic nitro compound.There are provided: a method for producing an aromatic amine compound which comprises a step of hydrogen...
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JP2014523899A |
The manufacturing method of an amino pro pin including the process to which metal acetylide, amine, and a carbonyl content compound are made to react, or enemy non is provided under existence of a transition metal catalyst. The manufactu...
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JP5591714B2 |
Ligands for transition metals are disclosed herein, which may be used in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The disclosed methods provide improvements in many features of the tr...
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JP5548182B2 |
A process for the preparation of indanones of the formula II from indanones of the formula I or of indanones of the formula IIa from indanones of the formula Ia comprises reacting an indanone of the formula I or Ia with a coupling compon...
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JP5543150B2 |
To provide a catalyst for selectively and economically hydrogenating only a nitro group even when the nitro group, a carbon-carbon double bond, a halogen atom bonded to an aromatic ring, and groups such as an aromatic ketonic carbonyl gr...
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JP5529591B2 |
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JP5514218B2 |
A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]p
ropan-1-amine of formula (I) i.e. Cinacalcet and its intermediates of formulae (V), (Va) and (Vb).
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JP5508738B2 |
Producing ketone compounds (I), comprises reacting alpha-oxocarboxylate compounds (II) with aryl bromide compounds (III) in the presence of two transition metals or compounds as catalyst. Producing ketone compounds of formula (R-C(=O)-R1...
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JP5391372B2 |
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JP5342887B2 |
To provide a method for producing an α-aminoketone compound in one step by using a tri- or more hydric alcohol. The method for producing the α-aminoketone compound comprises reaction of the tri- or more hydric alcohol (B) with a second...
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JP5291854B2 |
The present invention provides a method represented by Scheme 1: wherein X represents I, Br, Cl, alkylsulfonate, or arylsulfonate; Z represents optionally substituted aryl, heteroaryl or alkenyl; L represents hydrogen or a negative charg...
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JP2013533267A |
The disclosure relates to a process for preparing benzofuran derivatives of general formula I: in which R, R1, and R2 are as defined in the disclosure; by coupling the hydroxylamine with a diketone of general formula III: in order to for...
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JP5266499B2 |
The present invention provides a method represented by Scheme 1: wherein X represents I, Br, Cl, alkylsulfonate, or arylsulfonate; Z represents optionally substituted aryl, heteroaryl or alkenyl; L represents hydrogen or a negative charg...
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JP5209832B2 |
Derivatives of aryl and heterocyclic ureido and aryl and heterocyclic carboxamido phenoxy isobutyric acids have been found to inhibit the nonenzymatic glycation of proteins which often results in formation of advanced glycation endproduc...
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JP5203468B2 |
A process for preparing 3-amino-3-cyclobutylmethyl-2-hydroxypropionamide of the Formula I: or a salt thereof involves providing a compound of the Formula VI described herein in a solution comprising predominately dimethylsulfoxide (DMSO)...
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JP5197320B2 |
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JP5142178B2 |
The invention provides a novel immobilized Lewis acid catalyst which exhibits high catalytic activity in an aqueous solution and which permits recovery and reuse or long-term continuous use. The invention relates to an immobilized Lewis ...
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JP5125008B2 |
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JP5105413B2 |
A process for the preparation of indanones of the formula II from indanones of the formula I or of indanones of the formula IIa from indanones of the formula Ia comprises reacting an indanone of the formula I or Ia with a coupling compon...
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JP5105296B2 |
Functional group-selective hydrogenation catalyst for an organic compound containing at least a functional group of an aliphatic carbon carbon double or triple bond, an aromatic formyl group and an aromatic nitro group, comprises a carri...
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JP2012532993A |
Disclosed are processes for the use of bis-ketoiminate copper precursors for the deposition of copper-containing films via Plasma Enhanced Atomic Layer Deposition (PEALD) or Plasma Enhanced Chemical Vapor Deposition (PECVD).
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JP5093798B2 |
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JP5085930B2 |
The Invention relates to novel ketones of formulae (I) and (II) wherein R1, R2, R3 and R4 are, for example, C1-C8alkyl, R5 is, for example, hydrogen, A is CI, Br, -0-R7, -NR8R9 or -S-R16, A' is -O-, -NH- or -NR8-, X and Y are each indepe...
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JP2012525372A |
Methods for producing amrubicin and structural analogs thereof. The present invention encompasses synthetic pathways for the production of amrubicin (Formula I) and structural analogs thereof. The synthetic pathways of the present invent...
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JP2012197273A |
To provide a method for industrially and advantageously producing an aromatic amine compound with a high selectivity.There is provided the method for producing the aromatic amine compound by carrying out a hydrogenation reaction using an...
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