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WO/2009/080755A1 |
A process for the continuous production of a compound of Formula (II), HO-R1-ONO2 (II) wherein R1 is a straight chain alkyl radical having from 3 to 6 carbon atoms, in a two-phase solvent system, comprising contacting a compound of Formu...
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WO/2009/049961A2 |
The present invention refers to new NO-donors aspirin derivatives, a process for their preparation and pharmaceutical compositions containing them.
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WO/2009/046992A1 |
The present invention relates to a process for the preparation of organic nitrates having at least one nitryloxy and at least one hydroxy group, wherein the at least one hydroxy group may be present in form of an esterified hydroxy resid...
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WO/2009/007230A1 |
The present invention relates to nitrooxyderivative of antioxidant compounds of formula (I) and pharmaceutically acceptable salts or stereoisomers thereof for the treatment of chronic pain, in particular chronic neuropathic pain. The inv...
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WO/2009/004990A1 |
It is intended to provide a prostaglandin F2α receptor agonist (FP receptor agonist), which comprises a biphenyl derivative represented by the following general formula (I) (wherein m represents an integer of 0 to 2; n represents an int...
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WO/2009/000723A1 |
The present invention relates to a process for the preparation of 1,4-butanediol mononitrate as intermediate for large scale preparation of high purity nitrooxybutyl ester of pharmaceutically active compounds.
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WO/2008/157537A2 |
Disclosed herein are novel compositions and methods for treating or preventing a variety of disorders and conditions associated with lipid metabolism. The methods generally include administering to a patient in need thereof a therapeutic...
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WO/2008/128832A1 |
Non-peptidic renin inhibitors nitroderivatives of general formula (I) : A1- (Xa-ONO2) j wherein A1 is selected from the group consisting offormula (Ia), (Ib), (Ic), Id), (Ie) and (If). They can be employed for treating or preventing card...
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WO/2008/113863A2 |
The present invention relates to nitrosated derivatives of 2,5- dihydroxybenzene compounds that are useful in the preparation of medicinal products for the treatment of different diseases. The diseases in question are, in particular: (a)...
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WO/2008/095841A2 |
The invention relates to nitric oxide donor compounds and their use for treating cardiovascular diseases, inflammation, pain, fever, gastrointestinal disorders, ophthalmic diseases, hepatic disorders, renal diseases, respiratory disorder...
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WO/2008/092809A1 |
Branched decyl nitrates of the formula R1 R2 CH-CH 2-O-NO 2, wherein R1 denotes an n-propyl or iso-propyl group and R2 is a linear or branched alkyl group having 5 carbon atoms, are suited as combustion improvers and/or cetane number imp...
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WO/2008/071421A1 |
Nitroderivatives of carbonic anhydrase inhibitors having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma, ocular hypertension, age-related macular degeneration...
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WO/2007/060112A1 |
The present invention refers to O-acyl salicylic acid derivatives (I) bearing a NO donor moiety, a process for their preparation and pharmaceutical compositions containing them. (I) wherein : D is ONO2 or (A).
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WO/2006/130982A1 |
The present invention is directed to compounds, combinations, compositions and methods for enhancing nitric oxide (NO) delivery to target sites, and in particular to muscle, both normal and dystrophic. Enhanced NO delivery according to t...
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WO/2006/029532A1 |
Nitrate esters and methods for mitigating neurodegeneration, affecting neuroprotection, affecting cognition enhancement, and/or preventing or mitigating tissue and/or cellular damage in a subject are described. Neurological or cognitive ...
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WO/2006/015930A1 |
The present invention relates to the use of a compound of the general formula (I): wherein: n is an integer from 1 to 20; R is H, an halogen atom, a linear or branched (C1-C10)- alkoxy group, an hydroxy group, -CF3, -NHR' wherein R' is H...
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WO/2006/008196A1 |
The present invention relates to a process for preparing nitrooxy esters, nitrooxy thioesters, nitrooxy carbonates and nitrooxy thiocarbonates of compounds having at least a hydroxyl or thiol functional group, according to the following ...
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WO/2005/070868A1 |
The invention is directed to a method for treating a cyclooxygenase-2 mediated disease or condition in a mammalian patient at risk of a thrombotic cardiovascular event, wherein the patient is on aspirin therapy to reduce the risk of the ...
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WO/2005/065361A2 |
Compounds are disclosed with activity towards killing dysproliferative cells in vitro and treating cancer in vivo. Cancers such as cancer of the colon, pancreas, prostate, lung, breast, urinary bladder, skin and liver are exemplary. Comp...
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WO/2005/060603A2 |
The invention describes novel pyruvate compounds comprising at least one nitric oxide releasing group and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one pyruvate compound comprising at least one...
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WO/2005/053685A1 |
The present invention relates to β-adrenergic blockers nitrooxyderivatives of general formula (I): A-(Y-ONO2)s, wherein s is an integer equal to 1 or 2; A is selected from the following β-adrenergic blockers residues of formula (II), w...
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WO/2005/034960A1 |
Compounds and methods are provided for treating patients suffering from health condition associated with an expression state of a gene such as fertility disorders, cancer, proliferative dis5ases, vascular diseases, wounds requiring thera...
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WO/2004/062598A2 |
The invention encompasses compounds of Formula (I), which are antis inflammatory and anti-thrombotic agents. The invention also encompasses certain pharmaceutical compositions and methods for treatment of cyclooxygenases (COX-1 and COX-2...
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WO/2004/043897A1 |
A process for the purification of 1,4-butanediol mononitrate from 1,4-butanediol dinitrate and 1,4-butanediol, by selective extraction with solvents is herein disclosed.
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WO/2004/043898A1 |
A process for the preparation of compounds of formula: HO-A-ONO2 (I) wherein A is a C2-C6 alkylene chain by nitration of the corresponding alkanediols with 'stabilised' nitric acid is herein disclosed. The process is safer to operators a...
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WO/2004/020384A1 |
The present invention refers to a process for preparing a compound of general formula (A), wherein R is a radical of naproxen or bromonaproxen and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independently an integer...
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WO/2004/020385A1 |
The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of a drug and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independent...
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WO/2004/012506A2 |
Novel antimicrobial compounds are disclosed. Representative antimicrobial compounds have the following chemical structure. (I)
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WO/2004/004648A2 |
The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound ...
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WO/2003/045896A1 |
The present invention relates to a new process for the preparation of the ($i(S))-naproxen 4-nitrooxybutyl ester and to new intermediates obtained and used therein. The invention further relates to the use of the new intermediates for th...
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WO/2003/014059A1 |
The invention relates to a continuous method for producing alkyl nitrites and alkyl dinitrites. According to said method, (i) an alkanol or dialkanol is mixed with an aqueous solution of a mineral acid, whereby on average no more than 1....
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WO/2003/000642A2 |
Nitro-oxyderivative compounds or salts thereof having the following general formula (I): A-(B)¿b0?-(C)¿c0?-NO¿2? wherein: c0 is an integer and is 0 or 1, b0 is an integer and is 0 or 1, A = R-T¿1?-, wherein R is the radical of an ana...
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WO/2003/000643A1 |
Nitrooxyderivative compounds or salts thereof having the following general formula (I): A-(B)¿b0?-(C)¿co?-NO¿2? (I) wherein: c0 is an integer and is 0 or 1, b0 is an integer and is 0 or 1, A = R-T¿1?-, wherein R is the radical of for...
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WO/2002/100824A1 |
The present invention is to provide a novel colchicine derivative represented by the formula (I) with halogen or nitric ester group, or pharmaceutically acceptable salts thereof, pharmaceutical compositions containing the same as effecti...
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WO/2002/034260A1 |
The present invention provides compositions useful for the treatment of inflammation in humans, and related methods of treatment for the same. In one embodiment the composition is In another embodiment, the composition is In yet another ...
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WO/2002/030867A2 |
Use for the diabetes treatment of compounds or salts thereof, having the following general formula (I): A-(B)¿b0?-(C)¿c0?-NO¿2? wherein A contains the radical of a drug having an antiiflammatory or analgesic activity, B is a bivalent ...
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WO/2002/030866A1 |
Use for the treatment of diseases having an inflammatory basis of compounds or salts thereof, having the following general formula (I): A-X¿1?-L-(W)¿p?-NO¿2? wherein A contains the radical of a drug, X¿1? and W are bivalent radicals,...
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WO/2001/074754A1 |
The invention concerns a method for preparing alkyl nitrites of formula (I) R ONO wherein R represents a C¿1?-C¿20?, advantageously C¿2?-C¿10? linear or branched alkyl group. The invention is characterised in that it consists in grad...
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WO/2001/049275A2 |
Methods and therapeutic compounds for treating pain, mitigating inflammation, effecting analgesia and/or effecting sedation in a subject are described. A subject is administered an effective amount of a therapeutic compound which is a ni...
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WO/2001/028975A2 |
The invention relates to a method for production of 3-nitryloxy-2,2-bis(nitryloxymethyl)-propanal.
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WO/2001/012584A2 |
Compounds or their salts of general formula (I): A$m(Y)B$m(Y)N(O)¿s? wherein: s is an integer equal to 1 or 2; A = R$m(Y)T¿1?-, wherein R is the drug radical and T¿1? = (CO)¿t? or (X)¿t'?, wherein X = O, S, NR¿1c?, R¿1c? is H or a...
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WO/2001/010814A1 |
A process for obtaining nitroxyalkylesters of the 2-(S)-(6-methoxy-2-naphthyl)-propanoic acid having an enantiomeric excess higher than or equal to 95 %, preferably higher than or equal to 98 %, characterized in that an halide of the 2-(...
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WO/2001/004082A1 |
A process for obtaining (nitroxymethyl)phenyl esters of salicylic acid derivatives of formula (I) wherein R¿1? is the OCOR¿3? group characterized in that it comprises the following steps: a) reaction of a halide of a salicylic acid der...
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WO/2001/002336A1 |
A method for preparing either the 1,2-dinitrate or the 1,3-dinitrate of glycerol involves protecting glycidol respectively with either trialkylsilyl ether group or an acetate group then nitrating with dinitrogen pentoxide under anhydrous...
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WO/2001/000563A1 |
Compounds of formula A-X¿1?-ONO¿2? (I) in a partially or completely amorphous form and pharmaceutical compositions thereof.
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WO/2000/069803A1 |
A process for the preparation of nitro compounds by reacting an organic substrate with nitrogen dioxide either in the presence of oxygen or under such conditions that the nitrogen dioxide/organic substrate ratio is less than 1 by mole. T...
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WO/2000/061537A2 |
Compounds or their salts having general formulas (I) and (II): wherein s is and integer equal to 1 or 2, preferably s = 2; A is the radical of a drug and is such as to meet the pharmacological tests reported in the description, C and C¿...
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WO/2000/058261A1 |
A solid nitrating reagent comprises either a montmorillonite clay or a zeolite material incorporating an amount of gaseous dinitrogen pentoxide. The clay material can be type K10 and suitable zeolites include those designated ZSM-5, zeol...
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WO/2000/054756A2 |
Compounds and methods for mitigating neurodegeneration, effecting neuroprotection and/or effecting cognition enhancement in a subject are described. Neurological or cognitive conditions are treated by administering to a subject an effect...
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WO/2000/044705A1 |
The invention describes a method for the synthesis of nitroxymethylphenyl esters of aspirin derivatives.
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