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WO/2019/162149A1 |
The present invention relates to a process for preparing the hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hept
en-1-yl]- 3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl ester of formula ...
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WO/2019/159596A1 |
Provided is a method for preparing a coupled body represented by general formula (3), the coupled body being obtained by reacting a compound represented by general formula (1) and a compound represented by general formula (2) in the pres...
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WO/2019/154728A1 |
The present invention relates to processes for preparation of 1 -nitrobenzene-2- alkyloxycarbonyl-5-carboxylic acid. In particular, the present invention relates to preparation of 1 -nitrobenzene-2-alkyloxycarbonyl-5-carboxylic acid by p...
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WO/2019/111280A1 |
The present invention discloses a process for nitration of benzene. More particularly, the present invention discloses an efficient, environmental friendly process for the nitration of benzene using a modified solid acid catalyst.
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WO/2019/102388A1 |
The present invention relates to a stable pharmaceutical composition of tetrofosmin or pharmaceutically acceptable salts thereof. It also relates to a lyophilized non-radioactive kit which upon reconstitution with 99mTc -pertechnetate so...
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WO/2019/099371A1 |
Provided herein are compounds that are prodrugs for mesalazine. Generally, the compounds described herein correspond to a mesalazine molecule wherein the amino group is replaced by a novel protecting group. For example, in the compounds ...
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WO/2019/031774A1 |
The present invention relates to a method for preparing latanoprostene bunod, and an intermediate therefor. According to the preparation method of the present invention, latanoprostene bunod can be efficiently and economically prepared w...
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WO/2019/016110A1 |
The invention discloses a method for preparation of 5-fluoro-2-methyl-3-nitrobenzoic acid and its methyl ester by conversion of 5-fluoro-2-methylbenzoic acid with fuming nitric acid and oleum and subsequent conversion with methanol.
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WO/2019/011709A1 |
The invention pertains to a process for manufacturing a mixture of straight-chain higher ethyleneamines and non-straight-chain higher ethyleneamines selected from branched higher ethyleneamines and cyclic higher ethyleneamines, or the ur...
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WO/2018/187542A1 |
Amine-catalyzed formation of cyclic allylic nitro compounds via nitro-aldol reaction is disclosed. A greener solvent and a cheaper, more robust catalyst than in previous reports are used in the nitro-aldol reaction. After screening a ran...
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WO/2018/179808A1 |
Provided is a method for producing alkyl nitrite by bringing an aqueous solution containing nitric acid and an alkanol into contact with a gas containing nitrogen monoxide to generate alkyl nitrite, wherein the reaction temperature is 60...
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WO/2018/162427A1 |
The invention relates to a method for continuous production of nitrobenzene by means of nitration of benzene with nitric acid and sulphuric acid, in which load change (i.e. a reduction or increase in the quantity of nitric acid supplied ...
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WO/2018/149813A1 |
The present invention relates to a process for preparing substituted 2-nitrobiphenyls via Suzuki coupling using a palladium catalyst with specific phosphorus ligands and a solvent mixture containing water and an organic solvent which is ...
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WO/2018/141642A1 |
The present invention relates to an improved process for the preparation of 2-chloro-4-fluoro-5-nitrobenzotrichloride. The present invention further relates to a process for the purification of 2-chloro-4-fluoro-5-nitrobenzotrichloride, ...
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WO/2018/144101A1 |
Described herein are labeling agents, specifically [11C]fluoroform, [11C]difluoromethane, [11C]fluoromethyl iodide, [11C]fluoromethyl bromide, [11C]fluoromethyl chloride, [11C]fluoromethyl trifluoromethansulfonate, [11C]difluoromethyl io...
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WO/2018/141451A1 |
The invention relates to a method for preferably adiabatic nitriding of nitrable aromatic organic compounds (aromates) and to a corresponding system, in particular a production plant (nitration plant) for carrying out said method.
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WO/2018/116107A1 |
Provided are IDO inhibitor compounds of Formula (I) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases ...
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WO/2018/107450A1 |
This invention provides an electrochemical process for producing a propiolactone compound comprising reacting a compound having at least one ethylenically unsaturated carbon-carbon double bond with carbon dioxide in the presence of an el...
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WO/2018/068733A1 |
The present invention provides a method for preparing nintedanib. The method of the present invention is carried out by using 4-halo-3-nitro-benzoic acid methyl ester (compound II) and 3-oxo-3-phenylpropionate (compound III) as raw mater...
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WO/2018/033866A1 |
The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate comp...
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WO/2018/025295A1 |
The present invention relates to a process for preparing 3-pyrrolidine carboxylic acid derivatives, and particularly a simple process for preparing 5-substituted 3-pyrrolidine carboxylic acid derivatives. In addition, the present inventi...
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WO/2017/212059A1 |
The present invention relates to a new process of manufacturing of caged cyclofen-OH and derivatives thereof, of formula (I) or salts thereof, wherein n, R1, R1 ', R2, and R3 are as defined in the claims.
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WO/2017/195619A1 |
The purpose of the present invention to provide a method for producing a nitrobenzene compound represented by general formula (1), which is economically preferable, and suitable for industrialization. The present invention pertains to a ...
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WO/2017/156688A1 |
Disclosed in the present invention is a preparation method for a nitroolefin derivative, the method comprising the following steps: adding an ethylene compound, sodium nitrite, manganese dioxide and 2,2,6,6-tetramethylpiperidinyloxy to a...
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WO/2017/142028A1 |
A metal-supported macromolecule and a use thereof as a catalyst, said metal-supported macromolecule being obtained by causing a ligand to react with a zinc compound or a cobalt compound, said ligand having an imidazole group that is bond...
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WO/2017/114058A1 |
The present invention discloses a method for preparing an optically active carbonyl compound, comprising the following steps: subjecting an α,β-unsaturated aldehyde or an α,β-unsaturated ketone to an asymmetric hydrogenation catalyze...
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WO/2017/100985A1 |
Disclosed is a method for preparing 2,2-dihalo-1,3-dicarbonyl derivatives. The method is applicable in a broad range of 1,3-dicarbonyl derivatives, which have various types of readily available raw materials. The method is utilized to pr...
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WO/2017/090569A1 |
This catalyst contains neodymium, sodium, and a ligand which is a compound represented by structural formula (1), wherein the neodymium and the ligand form a complex at a molar ratio of 1 : 2 (neodymium : ligand).
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WO/2017/089492A1 |
The present invention concerns a method of synthesizing a iodo- or astatoarene comprising the reaction of a diaryliodonium compound with a iodide or astatide salt, respectively. The invention also relates to said iodo- or astatoarene and...
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WO/2017/051856A1 |
A method for producing a specific enantiomer in a larger amount than the other enantiomer, said method comprising reacting a reaction substrate in the presence of cellulose nanofiber or a derivative thereof and a catalyst so as to improv...
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WO/2017/046118A1 |
The invention discloses a method for the continuous preparation of n-butyl nitrite with a low content of n-butanol comprising the reaction of n-butanol, an acid and NaNO2 in a continuous way, in which the n-butanol, an acid and NaNO2 are...
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WO/2017/008832A1 |
Polymer supported fluorinated compound of formula I, wherein the meaning for each R1 is as disclosed in the description. These compounds are useful as catalysts, particularly in Michael addition reactions under continuous flow.
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WO/2017/005606A1 |
The invention discloses a method for the preparation of carboxylic acid chlorides starting from methyl ketones with a sulfur chloride and a chlorinating reagent.
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WO/2017/005907A1 |
The invention relates to zeolitic adsorbents based on agglomerated crystals of zeolite X comprising barium, potassium and sodium. These adsorbents are applicable in the separation of fractions of aromatic C8 isomers, especially xylenes.
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WO/2017/005908A1 |
The invention relates to zeolitic adsorbents based on agglomerated crystals of zeolite X comprising barium, potassium and sodium. These adsorbents are applicable in the separation of fractions of aromatic C8 isomers, especially xylenes.
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WO/2016/198921A1 |
A process for removing impurities from crude nitrated aromatic products obtained during the nitration of aromatic compounds. The nitrated aromatic products (1) are purified by treatment with ammonia washing (102) followed by caustic wash...
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WO/2016/173960A1 |
The invention relates to an optimized synthesis of pregabalin and additional 4-aminobutane acids using an improved method for producing conjugated nitroalkenes. This is achieved by a nitro-aldol reaction of an aliphatic aldehyde with a n...
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WO/2016/140358A1 |
The purpose of the present invention is to provide a catalyst composite body which has an excellent reducing action. The above-described problem is able to be solved by a catalyst composite body according to the present invention, which ...
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WO/2016/127723A1 |
The present invention relates to the field of organic compound synthesis. Disclosed are salicylic acid trans-(β)-farnesene analogues, and a preparation method therefor and uses thereof. The compound is obtained by: mixing salicylic acid...
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WO/2016/128147A1 |
Disclosed is an apparatus for producing polyethylene glycol dinitrate. The apparatus includes providing continuously an acid composition and a glycol composition to a reaction apparatus; reacting the acid composition and the glycol compo...
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WO/2016/128924A1 |
The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new c...
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WO/2016/127492A1 |
A tetra-phenolic compound/tetra-functionality epoxy resin, a preparation method and application thereof. The tetra-phenolic compound is obtained by reacting p-hydroxybenzaldehyde with an alkyl bromide, and then reacting the product there...
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WO/2016/125185A2 |
The present invention provides the process for the preparation of 4-substituted-1- (trifluoromethoxy) benzene compounds..
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WO/2016/118450A1 |
The present invention provides a process for nitrating aromatic compounds without the need for a solid catalyst and/or any organic solvents and/or any other additives. A typical process includes combining or admixing a nitric acid and an...
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WO/2016/114310A1 |
The purpose of the present invention is to provide a novel method for producing a nitro compound that is a precursor compound of a diamine compound, which is a raw material for a polyimide and/or polyamic acid used in a liquid crystal al...
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WO/2016/079759A9 |
The present invention relates to a novel simple, efficient and single-step process for esterification of aldehydes using a heterogeneous catalyst with high yields. More particularly, the present invention relates to a novel simple, effic...
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WO/2016/095684A1 |
The present invention provides a himbacine analogue and a method for preparing an intermediate thereof, and particularly provides a new method for preparing a compound A, a compound 4, a compound D and a compound C. In the solution for p...
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WO/2016/086722A1 |
Disclosed is a preparation method for an isoxazole compound and an intermediate thereof, the method comprising: a compound (I), as the starting material, is subjected to a substitution reaction with a compound (II) in the presence of a b...
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WO/2016/086710A1 |
Disclosed is a carboxylic acid preparation method. The method is characterized in that: a compound (II) reacts in the presence of hydrogen peroxide and a base to produce a target product (I) represented by the following equation: R1 is a...
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WO/2016/082780A1 |
The present invention relates to α-asary-laldehyde ester, a preparation method therefor, and an application thereof. The chemical structure of the related α-asary-laldehyde ester is represented by formula I. A related application is an...
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