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WO/2017/089492A1 |
The present invention concerns a method of synthesizing a iodo- or astatoarene comprising the reaction of a diaryliodonium compound with a iodide or astatide salt, respectively. The invention also relates to said iodo- or astatoarene and...
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WO/2017/087207A1 |
The invention provides novel chemical compounds useful for treating various hematologic malignancies and inflammatory and autoimmune diseases or a related disease or disorder thereof, and pharmaceutical composition and methods of prepara...
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WO/2017/076879A1 |
Radiotracer compositions comprising a radiotracer compound comprising [18F]SO3F-, [18F]PF6 - or [18F]PO2F2 -, methods of synthesising such radiotracer compounds, kits for synthesising such compounds, and the use of such compounds in a di...
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WO/2017/079003A1 |
The invention provides novel chemical compounds useful for treating various blood cancers, or a related disease or disorder thereof, and pharmaceutical composition and methods of preparation and use thereof.
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WO/2017/078928A1 |
Novel FXR agonists are disclosed, embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subje...
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WO/2017/072200A1 |
The present invention relates to new and improved methods of synthesizing radiolabelling agents which can be used to label biomolecules for use as radiopharmaceuticals. It further relates to certain novel radiolabelling agents and their ...
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WO/2017/070752A1 |
The present invention provides certain thiosemicarbazone metal complexes which have advantageous properties in medical imaging. The thiosemicarbazone metal complexes can be safely and easily produced in real time, administered quickly af...
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WO/2017/065899A1 |
Described are deuterated chlorokynurenines and compositions, and their application as pharmaceuticals for the treatment of disease. Methods of modulating N-methyl-D-aspartate (NMDA) receptor activity, methods of treating disorders, inclu...
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WO/2017/055859A1 |
The invention provides a compound of formula (I): (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions co...
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WO/2017/055860A1 |
The invention provides a compound of formula (I): (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions co...
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WO/2017/050259A1 |
Provided are prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.
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WO/2017/029820A1 |
The present invention relates to: a radioactive halogen-labeled pyrido[1,2-a]benzimidazole derivative compound represented by a specific general formula or a salt thereof; or a radioactive medicine comprising the compound or the salt.
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WO/2017/006931A1 |
The present invention provides a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof. This compound is capable of specifically binding to an AMPA receptor, and shows extremely high brain u...
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WO/2016/201128A1 |
The present application provides, inter alia, chemical compounds useful as synthesis intermediates, said compounds comprising one or more guanidinium moieties and a hypervalent iodine atom. Methods for making these compounds are also pro...
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WO/2016/201125A1 |
This disclosure relates to radioiodinated compounds useful as bioconjugation reagents, and intermediates for making radioiodinated bioconjugation reagents.
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WO/2016/198374A1 |
Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a di...
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WO/2016/192586A1 |
Provided are a deuterium-substituted dehydrophenylahistin-like compound, preparation method thereof and use in a preparation of antitumor drugs. The deuterium-substituted dehydrophenylahistin-like compound has a structure of general form...
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WO/2016/194586A1 |
A radioactively labeled compound production device (100) is a production device for producing a radioactively labeled compound by introducing a radioactive isotope into a non-radioactively labeled precursor compound. The production devic...
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WO/2016/184980A1 |
The invention relates to a method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, which method comprises carrying out a first synthesis run comprising the steps of: a) providing water contai...
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WO/2016/176572A1 |
Disclosed are boron mimics of amino acids which are compounds, salts, solvates, or stereoisomers of the Formula (I): wherein A, R.1, R2, and R3 are defined herein, and processes for the preparation of the compounds, salts, solvates, or s...
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WO/2016/160945A1 |
This invention relates to novel, deuterated forms of VX-661 and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of t...
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WO/2016/153054A1 |
Provided are an efficient method for producing a nitrogen-containing compound or salt thereof to be used in the production of a treatment agent for diseases involving an integrin. Also provided is a production intermediate of the same. A...
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WO/2016/151295A1 |
The present invention relates to a process for producing an organic compound comprising an 18F atom, which process comprises treating a precursor organic compound comprising a –CY2X group with: (i) [18F] fluoride; and (ii) an activator...
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WO/2016/145156A1 |
This disclosure relates to compositions comprising substituted iminodiacetic acid ligands and metal tricarbonyl complexes containing the ligands and derivatives thereof. In certain embodiments, the metal tricarbonyl complexes are used as...
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WO/2016/142702A1 |
A method for preparing a complex comprising a radioisotope of gallium for use in radiotherapy or in a medical imaging procedure, said method comprising adding a gallium radioisotope solution obtained directly from a gallium radionuclide ...
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WO/2016/140118A1 |
A radioactive iodine labeled pyrido[1,2-a]benzoimidazole derivative compound represented by a definite general formula or a salt thereof, or a radioactive medicine comprising the same.
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WO/2016/124508A1 |
The invention relates to 9H-pyrrolo-dipyridine derivatives of formula I, processes for preparing them, pharmaceutical compositions containing them and their use as radiopharmaceuticals in particular as imaging agents for the detection of...
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WO/2016/116875A1 |
Preparation of novel 2-benzyl-5-methyl-2H-tetrazole derivatives of the formula (I) for use as PET imaging agents. The present invention relates to novel compounds of formula (I) their preparation and use as PET imaging agents for imaging...
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WO/2016/105547A1 |
This invention relates to novel deuterated pyrimidinedione derivatives of Formula (I), and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such c...
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WO/2016/087586A1 |
The invention is directed to a triazolopyridazine compound of formula (I), N-oxides, pharmaceutically acceptable salts and solvates thereof, wherein D represents deuterium, the use of such compounds as protein tyrosine kinase modulators,...
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WO/2016/089814A1 |
This invention relates to novel 4,4'-di(1H-imidazol-5-yl)-1,1'-biphenyl compounds, and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compo...
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WO/2016/086036A2 |
The invention relates to water soluble 18 F-prosthetic groups and the synthesis and use of 18 F-labeled biological molecules containing the 18 F-prosthetic groups for imaging various processes within the body, for detecting the location ...
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WO/2016/076384A1 |
The present invention provides an organic EL element which sequentially comprises at least a positive electrode, a hole injection layer, a first hole transport layer, a second hole transport layer, a light emitting layer, an electron tra...
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WO/2016/075261A1 |
The present invention provides a new chemical process, a new cassette configuration, and new software for the automated production of multiple batches of an [18F]-labelled compound on a single cassette. The invention allows one synthesiz...
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WO/2016/075259A1 |
The present invention provides a new chemical process, a new cassette configuration, and new software for the automated production of multiple batches of an [18F] labelled compound on a single cassette. The invention allows one synthesiz...
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WO/2016/072104A1 |
The present invention provides a phosphonium compound indicated by formula (II). Also provided is a production method for a quaternary phosphonium compound labelled with positron emitting radionuclides, that includes a step in which: an ...
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WO/2016/067145A1 |
A quantitative imaging system (100) for automating delivery of a radiopharmaceutical and imaging a patient. The system (100) includes a QI controller (102) that controls the operation of the system. The system (100) includes a producer (...
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WO/2016/066534A1 |
The present invention relates to a compound of formula (I), wherein R is defined as in the description and in the claims. The compound of formula (I) can be used as radiolabeled ligand.
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WO/2016/070074A1 |
A method of producing a radiofluorinated compound comprising the steps of forming a reaction mixture comprising a reactant having a formula of R-Y and a radiofluorinating agent having a formula of R'-18F; and contacting the reaction mixt...
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WO/2016/065435A2 |
New chelators such as H3L1, H3L2, H3L3, H3L26 and derivatives were synthesized for the complexation of {Al18F}2+. These new chelators are able to complex {AI18F}2+ with good radiochemical yields using a labeling temperature of 37 °C. Th...
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WO/2016/065322A1 |
The present disclosure provides purified forms of iobenguane and preparations of a precursor to iobenguane, such as a polymer, the polymer comprising a monomer of formula (I) or a pharmaceutically acceptable salt thereof, the preparation...
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WO/2016/063072A1 |
Certain embodiments of the present invention relate to a system and a method for producing a radiopharmaceutical, wherein the system is formed from and/ or provides a microfluidic flow system. In certain embodiments, the system comprises...
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WO/2016/037098A1 |
This invention relates to deuterium substituted analogs of sacubitril and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in me...
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WO/2016/036674A1 |
Deuterated and non-deuterated forms of tetrahydrocurcumin are described herein. Methods of making tetrahydrocurcumin in deuterated and non-deuterated forms and pharmaceutical formulations including tetrahydrocurcumin in deuterated and no...
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WO/2016/020532A1 |
The present invention relates to method for chiral resolution of chiral species contained in a liquid placed in a cell formed by an inner wall and an outer wall surrounding the inner wall over at least a portion of the inner wall, each o...
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WO/2016/019038A1 |
Methods of isotopic labeling are described herein. For example, a method of isotopically labeling an organic compound, in some embodiments, comprises providing a reaction mixture including the organic compound, an iron complex or a cobal...
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WO/2016/013184A1 |
[Problem] To provide an organic electroluminescent element having high efficiency, low driving voltage and long service life by combining, as materials for an organic electroluminescent element having high efficiency and high durability,...
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WO/2016/009823A1 |
Provided is an organic thin-film luminescent element which includes a monoamine derivative represented by a specific structure and hence combines a high luminescent efficiency with durability.
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WO/2016/001199A1 |
The present invention provides a composition comprising anti-1-amino-3-18F- fluorocyclobutyl-1-carboxylic acid (18F-FACBC) having an improved impurity profile compared with previous such compositions. Also provided is a method to obtain ...
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WO/2015/190613A1 |
The present invention provides radiolabeled compounds useful as radiotracers for quantitative imaging of CH24H in mammals. The compound of the present invention is represented by the formula (I): wherein each symbol is as defined in the ...
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