| Document |
Document Title |
|
WO/2012/153684A1 |
Provided is a ruthenium complex that is represented by general formula (1*) and is useful as an asymmetric reduction catalyst. (In the formula, * is an asymmetric carbon atom; R1 is an arenesulfonyl group, and the like; R2 and R3 are a p...
|
|
WO/2012/147897A1 |
With the method for producing an amine compound (5) according to the present invention, that includes the following steps, it is possible to produce an amine compound regardless of the presence of inorganic salts. Step (1), a step in whi...
|
|
WO/2012/147925A1 |
Provided is a method for simply producing, by a short step and at a good yield, a stereospecific asymmetric five-membered ring-containing compound that serves as the synthesis intermediate for the formation of a five-membered ring such a...
|
|
WO/2012/137460A1 |
The present invention provides: a novel ruthenium complex which has excellent catalytic activity with respect to reactivity in the reduction of a multiple bond, in particular, in the asymmetric reduction of a carbonyl compound, enantiose...
|
|
WO/2012/121079A1 |
Provided is a compound represented by general formula (1). Also provided is a method for producing a compound represented by formula (1) that comprises a reaction step for reacting a compound represented by general formula (2), a compoun...
|
|
WO/2012/108367A1 |
A quaternary ammonium salt shown by formula (5) (in the formula, R1 represents a C1-4 alkyl group; R2 represents a C1-10 alkyl group; R3 represents a C1-10 alkyl group optionally substituted with one or more phenyl groups or a phenyl gro...
|
|
WO/2012/104866A1 |
Chiral l-(4-methylphenylmethyl)-5-oxo-{N-[(3-t-butoxycarbonyl-amino
methyl)]- piperidin-l-yl}-pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion The present invention provides chiral (2S)-l-(4-m...
|
|
WO/2012/093565A1 |
A method for producing α-amino-γ-butyrolactone or a salt thereof, which comprises a step wherein methionine and a haloacetic acid, namely chloroacetic acid or bromoacetic acid, are caused to react with each other in a solvent, and whic...
|
|
WO/2012/081585A1 |
The present invention provides a method for diastereo-selectively and enantioselectively producing an optically active alcohol compound indicated in formula (IIIa), etc., that includes hydrogenation of a carbonyl compound indicated in fo...
|
|
WO/2012/081582A1 |
The present invention provides a method for diastereo-selectively synthesizing an alcohol compound, that includes hydrogenation of a carbonyl compound indicated in formula (I) in the presence of a ruthenium compound indicated in formula ...
|
|
WO/2012/073991A1 |
[Problem] To provide: a pyrrole derivative useful as an immunosuppressing agent; and a process for producing the pyrrole derivative. [Solution] A process for producing a compound represented by general formula (I) by heating a compound r...
|
|
WO/2012/074075A1 |
The purpose of the present invention is to provide a method for manufacturing optically active menthol, which is composed of a few steps that are all catalytic reaction steps, and therefore produces little environment-polluting waste and...
|
|
WO/2012/074128A1 |
The present invention provides a catalyst used for manufacturing an optically active carbonyl compound by selective asymmetric hydrogenation of an α, β-unsaturated carbonyl compound, which is insoluble in a reaction mixture, and a meth...
|
|
WO/2012/065571A1 |
The present invention relates to a chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof. The chiral spiro-pyridylamidophosphine compound is a compound having a structure of Formula (I), a ...
|
|
WO/2012/063843A1 |
An optically active ketone represented by formula (2) (wherein Ar1 represents a furyl group, a thienyl group, or a C6-20 aryl group; X1 represents a halogen atom; and * represents an asymmetric point) is produced by stereoselectively red...
|
|
WO/2012/057093A1 |
The present invention provides a method for commercially advantageously producing, at low cost, an optically active form of an anti-(3S,4R)-3-alkylcarbamoyl-4-hydroxy pyrrolidine derivative or an enantiomer thereof that is a key intermed...
|
|
WO/2012/053565A1 |
Provided is a novel process for producing an optically active β-amino aldehyde compound from an imine compound. The present invention provides a process for producing an optically active β-amino aldehyde compound (3), which comprises a...
|
|
WO/2012/053564A1 |
Provided is a novel process for producing an optically active 4-chloro-3-hydroxybutanal compound. Specifically provided is a process for producing an optically active 4-chloro-3-hydroxybutanal compound (2), which comprises a step of reac...
|
|
WO/2012/051473A1 |
Disclosed herein are processes for preparing aqueous γ-hydroxybutyrate having a pH of about 8 or less (upon reaching equilibrium). The disclosed processes include both continuous processes and batch processes wherein the ratio of reacta...
|
|
WO/2012/048887A1 |
A process for the synthesis of chiral propargylic alcohols.
|
|
WO/2012/011516A1 |
Disclosed is a method that is for producing 1-bromo-1-[3,5-bis(trifluoromethyl)phenyl] ethane having high optical purity, and that is a method containing a step for brominating optically active 1-[3,5-bis(trifluoromethyl)phenyl] ethanol ...
|
|
WO/2012/008228A1 |
Disclosed is a method for oxidizing alcohols, wherein it is possible to efficiently oxidize primary alcohols and secondary alcohols and to achieve high reaction efficiency even when air is used as the bulk oxidant. Specifically disclosed...
|
|
WO/2012/005200A1 |
An industrially advantageous method for producing an optically active 1,2-bis(dialkylphosphino)benzene derivative, wherein borane is removed from a phosphine-borane compound (1), followed by lithiation, then the reaction product is react...
|
|
WO/2012/002203A1 |
Disclosed is a production method for obtaining an optically active β-aminocarbonyl compound by a Mannich reaction of an aldimine in which nitrogen is protected and a malonic acid diester, in the presence of optically active BINOL and 1-...
|
|
WO/2011/145352A1 |
A process for the preparation of optically active cyano compounds, which includes a step of reacting an α,β-unsaturated compound having a prescribed structure with a cyanating agent in the presence of a titanium-containing catalyst tha...
|
|
WO/2011/129365A1 |
Disclosed is an antitumor agent which has higher antitumor activity than conventional antitumor agents, while having low toxicity. Specifically disclosed is an antitumor agent which is characterized by containing a phosphine transition m...
|
|
WO/2011/126045A1 |
Provided is a process for the preparation of optically active 2,3-bisphosphinopyrazine derivatives, which is industrially advantageous and by which any isomer can be easily prepared. Specifically provided is a process for the preparation...
|
|
WO/2011/126082A1 |
An acyloxypyranone compound represented by formula (II) (wherein R1 represents an acyl group) is produced by causing an acylating agent and a hydrolase to act on hydroxypyranone represented by formula (I) in a hydrous organic solvent; an...
|
|
WO/2011/121797A1 |
A low cost, viable and modular method to prepare new, highly selective "catalytic membranes" and their use in various types of reactors is described. The membranes are versatile and reusable with negligible catalyst leaching, particularl...
|
|
WO/2011/118625A1 |
Disclosed is a method for producing an N-monoalkyl-3-hydroxy-3-arylpropylamine compound which is represented by general formula (2) (therein, Ar represents an optionally substituted aryl group or an optionally substituted heteroaryl grou...
|
|
WO/2011/111677A1 |
Disclosed is a novel bisphosphate compound that can be used with a wide range of reaction substrates and reactions as a catalyst for asymmetric reactions and can achieve an asymmetric reaction with a high yield and high asymmetric yield....
|
|
WO/2011/108672A2 |
Disclosed is a catalyst for producing an optically active aldehyde or optically active ketone, which are optically active carbonyl compounds, by the selective asymmetric hydrogenation of an α, β-unsaturated carbonyl compound, particula...
|
|
WO/2011/102388A1 |
Provided is a novel method for producing (1R,2S)/(1S,2R)-1-amino-1-alkoxycarbonyl-2-vinylcyclopropane
which is useful as an intermediate for synthesizing a therapeutic agent for hepatitis C, and also provided is a novel method for produ...
|
|
WO/2011/098160A1 |
The present invention relates to enantiomerically enriched aminodiphosphine ligands where the chirality is located in the phosphorus atom and their preparation process, to catalysts containing them and their preparation process, as well ...
|
|
WO/2011/078172A1 |
A process for producing an optically active 3-substituted glutaric acid monoamide, characterized by mixing a mixed solution of an optically active 3-substituted glutaric acid monoamide represented by formula (2) (wherein * represents an ...
|
|
WO/2011/073173A1 |
The present invention relates to an improved method for the synthesis of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular argyrin and derivatives thereof.
|
|
WO/2011/073362A1 |
A catalytic process for the preparation of optically active compounds and their conversion thereafter to desired drug substances. In particular, the process relates to the preparation of (S)-3-(1-Dimethylamino-ethyl)-phenol using asymmet...
|
|
WO/2011/073487A1 |
High-yield procedure for the preparation of compounds of formula (I) or a salt thereof, or any substantially pure enantiomeric form thereof, comprising the nucleophilic addition of organozinc compounds of formula (Rz)2Zn to compounds of ...
|
|
WO/2011/070028A1 |
Whilst methodologies for the Kinetic Resolution of alcohols are well established, no analogous direct methods exist for the highly selective, direct catalytic Kinetic Resolution of thiols (i.e., R-SH). The present invention relates to a ...
|
|
WO/2011/071058A1 |
Disclosed is an efficient industrial preparation method for an optically active 2-hydroxycycloalkane carboxylic acid ester that is useful as an intermediate for the production of pharmaceutical products. Specifically disclosed is a metho...
|
|
WO/2011/062280A1 |
Disclosed is a method for obtaining an optically active alcohol by highly enantioselective secondary alkylation, while suppressing side reactions. Specifically disclosed is a method for producing an optically active alcohol, which compri...
|
|
WO/2011/062139A1 |
Provided is a three-step method for manufacturing optically active 3-tert-butoxycarbonylamino-2-fluoro-1-propanol. The provided method can dramatically reduce the amount of a palladium catalyst used and can complete the reaction in one c...
|
|
WO/2011/061934A1 |
The disclosed method for producing a bicyclo [3.1.0] hexane represented by formula I or a salt thereof contains: a step for causing oxygen to act on a non-optically-active compound represented by formula II causing an asymmetric acylatio...
|
|
WO/2011/056737A1 |
The invention relates to a series of novel chiral phosphorus ligands of formulae (Ia) and (Ib): wherein R, 1 - rR> 4 and X are as defined herein. The invention also relates to chiral metal complexes prepared with these chiral phosphorus ...
|
|
WO/2011/048727A1 |
Provided is a ruthenium carbonyl complex represented by general formula (1). (1) RuXY(CO)(L) (In general formula (1), X and Y represent anionic ligands and may be the same as each other or different from each other; and L represents a tr...
|
|
WO/2011/043272A1 |
Disclosed are: a ligand for an asymmetric synthesis catalyst; and a process for producing an α-alkenyl cyclic compound using the ligand. Specifically disclosed are: a ligand for an asymmetric synthesis catalyst, which is represented by ...
|
|
WO/2011/035445A1 |
Novel polymeric rhodium catalysts having repeating subunits of Formula (I), wherein R1-R8, X, A, m, n and p are as defined in the application, are described along with methods of using these catalysts, as well as precursors therefor, in ...
|
|
WO/2011/026682A1 |
The invention relates to immobilized rhodium (III), ruthenium (II), or iridium (III) catalysts for asymmetric hydrogenation reactions.
|
|
WO/2011/019066A1 |
An optically active 1-amino-2-vinylcyclopropanecarboxylic acid ester represented by formula (4), which is useful as an intermediate in synthesizing a medicine, can be produced by a method comprising a step for subjecting an optically act...
|
|
WO/2011/012687A2 |
The present invention relates to phosphine borane compounds comprising imidazol groups, optically active ligands produced using said compounds, transition metal complexes comprising such ligands, and catalyzers comprising said transition...
|
