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WO/2021/017793A1 |
A method for preparing a chemically synthesized acidic polypeptide, which mainly solves the disadvantages of difficult impurity purification and low yield of an acidic polypeptide compound. The method is high performance liquid chromatog...
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WO/2021/019167A1 |
The invention relates to a method for purifying a target substance starting from a fluid to be treated which comprises at least one impurity, said method comprising the following steps: – provision of a stream of the fluid to be treate...
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WO/2021/021559A1 |
The present disclosure relates to scalable processes for extracting, refining and remediating extracts of natural products, such as plant material and for providing well controlled refined extracts.
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WO/2021/019275A1 |
The present invention relates to a method for the production of chromoplastid carotenoids that can be isolated from fruits. The procedure of the invention allows to selectively isolate, on the basis of the size (Size Exclusion Chromatogr...
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WO/2021/015129A1 |
The present invention provides a hydrophobic zeolite having both high hydrophobicity and high organic compound adsorption capacity, which have not been able to be achieved by conventional zeolites. A hydrophobic zeolite which has a wat...
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WO/2021/011436A1 |
The present disclosure provides methods for the separation and quantification of empty and full viral capsids (e.g., AAV capsids) within a viral preparation, such as a viral pharmaceutical composition or drug product.
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WO/2021/011965A1 |
The present invention includes a method of controlling an oil spill through introduction of a plurality of magnetizable particles into the oil spill in an amount sufficient to form a colloidal mixture. An absorbent is also introduced int...
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WO/2021/011567A1 |
A process is described for removing formaldehyde from an aqueous glycolaldehyde composition including water, glycolaldehyde and formaldehyde, and in particular embodiments, from a sugars pyrolysis product mixture including at least water...
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WO/2021/007066A1 |
A process for removing Hg2+ toxins from bodily fluids is disclosed. The process involves contacting the bodily fluid with a titanium metallate ion exchanger to remove the metal toxins in the bodily fluid, including blood and gastrointest...
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WO/2021/007243A1 |
Provided herein, inter alia, are compositions, systems, and methods for the purification of granulocyte colony- stimulating factor (GCSF). Also provided are GCSF obtained by the disclosed methods and systems, pharmaceutical compositions ...
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WO/2021/004977A1 |
The invention relates to a new process for the purification of oligonucleotides which comprises the removal of an acid labile 5'hydroxy protecting group at the 5'- O-oligonucleotide terminus of the oligonucleotide by means of an on-colum...
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WO/2021/007065A1 |
A process for removing Sr2+ toxins from bodily fluids is disclosed. The process involves contacting the bodily fluid with an ion exchanger to remove the metal toxins in the bodily fluid, including blood and gastrointestinal fluid. Altern...
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WO/2021/005212A1 |
The present invention relates to a method for producing a porous, plastics-polymer-based material element, to the material element produced using the method, and to the use thereof, in particular in the purification of water systems. The...
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WO/2021/001387A1 |
The present invention relates to an ion exchange separation material with amino-acid based endgroups. This material is especially suitable for the separation and purification of ADCs.
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WO/2021/002874A1 |
An improved gas chromatography system is presented. The system comprises: an enclosure having an inlet and an outlet, such that the ventilation flow is from the inlet to the outlet; a chamber disposed in the enclosure; a monolithic gas a...
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WO/2021/001741A1 |
The invention relates to a Protein A chromatography step of a purification process for a therapeutic protein, wherein a load solution including the therapeutic protein is applied onto a Protein A chromatography medium. According to the i...
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WO/2021/001388A1 |
The present invention relates to a method for the separation and purification of glycoforms with an ion exchange separation material with amino-acid based endgroups.
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WO/2020/261321A1 |
According to the present invention, a first chromatogram is obtained through a size exclusion chromatography analysis performed on a second standard specimen using a first detector. Further, a second chromatogram is obtained through a si...
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WO/2020/260074A1 |
The present invention relates to a computer implemented method (600) performed by a chromatography apparatus (400) configured to separate molecules, having varying size, from an eluent, the method comprising obtaining (610) reference dat...
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WO/2020/260073A1 |
The present invention relates to a method for monitoring operational status in a column capture chromatography system configured for cyclical repetitive purification performed on a volume of sample feed comprising at least one product co...
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WO/2020/260028A1 |
The invention relates to a process for separating xylose in the liquid phase from a mixture of C5 and C6 sugars comprising at least xylose and glucose, by adsorbing the xylose on a zeolite adsorbent which is based on FAU zeolite crystals...
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WO/2020/258706A1 |
Provided are a combined chromatography apparatus, a seamless connection chromatography method, and a biological agent purification method. The combined chromatography apparatus comprises at least two basic chromatography devices and at l...
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WO/2020/260027A1 |
The invention relates to a process for separating glucose in the liquid phase from a mixture of C5 and C6 sugars comprising at least xylose and glucose, by adsorbing the glucose on a zeolite adsorbent which is based on FAU zeolite crysta...
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WO/2020/257937A1 |
An apparatus and method for recovering metal from a solution comprising a metal-selective sorbent disposed in a column. Additional embodiments provide for using a metal-selective membrane configured for selective transport, isolation, re...
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WO/2020/261505A1 |
The present invention addresses the problem of providing: a triglyceride analysis method using supercritical fluid chromatography; a method for quantifying triglyceride by means of supercritical fluid chromatography and sorting oil and f...
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WO/2020/261221A1 |
A sample preparation device is provided for enriching a component of a sample. The sample preparation device includes a surface in fluid communication with the sample, an alkylsilyl coating disposed on the surface, and an affinity ligand...
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WO/2020/258705A1 |
A modular chromatography device, comprising a plurality of basic chromatography modules (M1, M2, M3), each of which comprises a chromatography column (C1, C2, C3), a sample injection selector valve (Vs) and an outlet valve (Vx); the samp...
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WO/2020/256494A1 |
The present invention relates to a method for analyzing a copolycarbonate. More specifically, the present invention relates to a method for analyzing a copolycarbonate, wherein in a copolycarbonate having a polysiloxane structure introdu...
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WO/2020/061296A9 |
The present disclosure relates to methodologies, systems, and devices for screening lipids. The technique includes selecting a set of standards to identify at least one desired class of lipids, spiking the standards into a biological sam...
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WO/2020/254483A1 |
The current application provides a rapid and simple method for measuring residual pDADMAC in a sample containing a recombinant protein of interest based on the combination of use of reversed-phase hydrophobic interaction HPLC and charged...
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WO/2020/256088A1 |
Provided is a novel porous cellulose medium which has a large volume of large-diameter pores and can efficiently separate a large target molecule having a weight average molecular weight of about 105.0-105.5 in a standard sample. This ...
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WO/2020/254176A1 |
The present disclosure is directed to method (100) for separating a biomolecule from a fluid (2), wherein the biomolecule is produced by biological cells in a perfusion bioreactor (3), the method comprising: forwarding (110) a product fl...
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WO/2020/249834A1 |
The present invention provides a stationary phase for solid-phase microextraction (SPME) devices based on nickel and titanium alloy nuclei and a metal-organic framework (MOF) exterior, which may be used for chromatographic analysis in en...
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WO/2020/251000A1 |
Adsorbent particles comprising: support particles comprising an organic polymer including monomer units derived from a styrene-based monomer; a hydrophilic organic compound adherent to the surface of the support particles; and a diglycol...
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WO/2020/251003A1 |
An amine separation method using liquid chromatography, according to the present invention, wherein a separating agent, in which a ligand having a crown ether-like cyclic structure is supported on a carrier, is used as a stationary phase...
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WO/2020/245800A1 |
The present technology relates to a method of analyzing a sample including an analyte. The method includes injecting the sample including the analyte into a mobile phase. The mobile phase includes a metal chelator additive having a conce...
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WO/2020/247634A1 |
The present invention provides methods for cleaning or regenerating a chromatography materiel for reuse. The methods of the invention can be used for cleaning or regenerating ion exchange chromatography columns for reuse in the large-sca...
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WO/2020/244376A1 |
Provided are a method for manufacturing a chromatographic separation micro-column, a chromatographic separation micro-column, and a gas analysis micro-system. The manufacturing method comprises: A, manufacturing a substrate of the chroma...
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WO/2020/161173A9 |
The present disclosure relates to a method and system for label-free characterization of the behavior of a component in a complex liquid sample, which does not require pretreatment of either the complex liquid sample or the first component.
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WO/2020/238953A1 |
A reversible enrichment material, preparation therefor, and application thereof. The enrichment material comprises an inorganic carrier; and an activated metal salt, a first auxiliary metal salt, and a second auxiliary metal salt that ar...
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WO/2020/241999A1 |
The present invention relates to an affinity separation system and method using a switch-like adhesion reaction. An affinity separation system according to an embodiment of the present invention comprises: a ligand (10); a binder (20) to...
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WO/2020/243502A1 |
The present invention relates to a novel analytical method for detecting one or more analytes in a source sample by continuous flow 2D LC-MS/MS using a single LC system.
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WO/2020/242969A1 |
Tailored chromatographic media and methods for using the tailored chromatographic media to purify mixtures extracted from cannabis to obtain a cannabinoid having greater than about 90% purity. In an embodiment, the tailored chromatograph...
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WO/2020/242751A1 |
A composition includes a hybrid ligand. The hybrid ligand includes an amine group, an amide group or a sulfonamide group, and hydroxyl groups. A first method includes providing a solution containing a first polar analyte and a second pol...
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WO/2020/232559A1 |
A method of removing hydrogen interstitially dissolved within an object can include: positioning a sorption pad having a contact surface and comprising a sorptive material; urging the contact surface into metallurgical contact with the f...
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WO/2020/237153A1 |
A method of sorbing a PFAS compound from a contaminated environment can include admixing a modified clay sorbent with the environment. The modified clay can include a clay intercalated with a blend of mono-quaternary amine compound and d...
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WO/2020/231787A1 |
Presented herein is a new concept of uniformly spin coating a flat surface with a stationary phase and creating a gas chromatography column by pressing a grooved lid, with micro-stamped ridges, down onto the coated substrate. The lids ar...
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WO/2020/227816A1 |
Porous cellulose microparticles and their use in, inter alias, cosmetic and pharmaceutic preparations are provided. These microparticles comprise cellulose I nanocrystals aggregated together, thus forming the microparticles, and arranged...
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WO/2020/231985A1 |
In some embodiments, a self-aligned electrospray device can include a silicon wafer, a fluid reservoir, and a circuit. The silicon wafer can have a layer of electrically insulating material deposited on a top surface and a deposited laye...
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WO/2020/230054A1 |
The technology generally relates to tailoring a back pressure regulator in a chromatographic system to reduce unswept volume within the back pressure regulator to achieve better sample detection and a reduction in chromatographic band di...
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