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WO/2019/189795A1 |
To provide a method for producing a large amount of novel yeast-derived microparticles at once without using any special device or reagent, provided is a method that comprises: step (A1) for heating a yeast suspension in which a yeast is...
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WO/2019/177142A1 |
The present invention provides: a prophylactic or therapeutic agent for hypoxic injury, ischaemia-reperfusion injury and inflammation; a cell protection agent for transplantation; and a bio-preservation agent. A prophylactic or therapeut...
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WO/2019/090003A9 |
Provided herein are chimeric antigen receptors (CARs), comprising an extracellular BCMA-binding domain, in particular a scFv. The CAR also comprises a spacer of at least 125 amino acids in length, a transmembrane domain, and an intracell...
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WO/2019/174003A1 |
Disclosed are Lactobacillus plantarum CCFM1019, a fermented food thereof and the use of same in preparing a drug. The bacterium is not only superior to the resident intestinal flora Escherichia coli and Enterococcus faecalis, but is also...
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WO/2019/169484A1 |
Doxorubicin (Dox), a potent anti-cancer drug, can cause cardiac dysfunction and failure. Endogenous Fibroblast Growth Factor-2 (FGF2), a protein implicated in cardioprotection, regulates cardiac vulnerability to Dox. In wild type mice an...
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WO/2019/172454A1 |
[Problem] To provide an emulsion composition with which it is possible to improve the absorption of various carotenoids into the body, the emulsion composition having excellent compatibility with soft capsules so as to enable soft-capsul...
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WO/2019/173159A1 |
Provided herein are methods and compositions for maintaining and/or increasing vitamin C in a cell or organism. The methods and compositions are based, in part, on the synergistic effect of ergothioneine, or a derivative thereof, on vita...
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WO/2019/172747A1 |
The present invention relates to processes and composition meant for delaying ageing process in a subject comprising of palm fruit juice whole or its fractions, alone or in combination with other components in the form of a composition. ...
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WO/2019/166475A1 |
The present invention relates to synthetic receptors for ionophoric compounds, such as ionophoric toxins. Hence, the invention provides synthetic molecules capable of binding different ionophoric compounds, thereby being suitable for use...
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WO/2019/167663A1 |
The purpose of the present invention is to provide a reduced coenzyme Q10-containing composition which is highly soluble in water and has an excellent storage stability and a method for producing the same. Provided are: a powdery composi...
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WO/2019/167177A1 |
The problem addressed by the present invention is to obtain a yeast culture having improved properties such as odor and color and to use the yeast culture as an aqueous base of a cosmetic having a skin condition-improving action. A topic...
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WO/2019/167547A1 |
One of the fish powders of this invention is a fish powder derived from Lampris guttatus in a dried state. This fish powder contains imidazole dipeptides, in particular extremely high levels of Balenine. Therefore, taking this fish powde...
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WO/2019/160654A1 |
The present invention provides a method for inhibiting chondroitinase activity in a substrate by introducing a non-substrate glycosaminoglycan (GAG) to the substrate containing the chondroitinase. non-substrate GAG is undegradable by cho...
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WO/2019/156510A1 |
The present invention relates to a novel synthesis method of DHPV and, more specifically, to a novel synthesis method of 5-3',4'-dihydroxyphenyl)-γ-valerolactone (DHPV) which is a major metabolite of cacao. The method has advantages in ...
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WO/2019/154161A1 |
The present application relates to a pharmaceutical composition for treating male diseases. The pharmaceutical composition comprises the following component in parts by mass: 10-30 parts of a hot water extract of Maca, 10-30 parts of a h...
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WO/2019/150087A1 |
The invention relates to compounds that provide protective effects against mitochondrial DNA damage. In particular, it relates to mangiferin, ideally in the form of a naturally-occurring mangiferin extract, and to mangiferin-containing c...
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WO/2019/148282A1 |
The present disclosure concerns methods and formulations for delivery of hydrophobic agents (such as ubiquinone or poorly soluble drugs) for therapeutic and bioanalytical use. It further concerns use of lipopeptides (e.g. caspofungin) or...
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WO/2019/134620A1 |
Disclosed is a use of E3 ligase FBW7 in preparing a drug for delaying aging and for preventing and treating aging-related diseases by means of inhibiting telomere damage, wherein the amino acid sequence of the FBW7 is as shown in SEQ. No...
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WO/2019/128499A1 |
The present invention relates to a ginkgo diterpene lactone composition. The composition has the effect of improving a depressive state; the composition can prolong a tail flick interval time and a swimming interval time of a mouse to di...
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WO/2019/131774A1 |
The present invention relates to a composition for inhibiting active oxygen production, the composition including, as an active ingredient: a triterpene acid that has an acetyl group; or a salt thereof.
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WO/2019/132004A1 |
A prophylactic agent or therapeutic agent for Alzheimer's disease characterized by containing a GM1 gangliosidosis prophylactic agent or therapeutic agent as an active ingredient. A screening method for prophylactic agents or therapeutic...
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WO/2019/128175A1 |
Disclosed are a cocrystal of tocopherol and proline and a preparation method therefor. The cocrystal is in crystalline or partially crystalline form in the environment of normal pressure and room temperature. Compared to the existing toc...
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WO/2019/132631A1 |
The present invention relates to a method for constructing an aging-regulating effectiveness factor by using stem cells, a method for screening an aging-regulating material by using the same, and an anti-aging material derived therefrom ...
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WO/2019/119938A1 |
Disclosed is a health wine, comprising 90-99% of white spirit, 0.05-1% of turtle shell, 0.05-1% of shark cartilage and 0.5-1% of garlic calculated by weight percentage. The method for preparing the health wine comprises: (1) drying the s...
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WO/2019/119664A1 |
A comprehensive antioxidant health care food product, consisting essentially of the following ingredients in percent by mass: 10% to 60% of a grape seed extract, 0.05% to 30% of a Polygonum cuspidatum extract, 0.05% to 30% of a radix cur...
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WO/2019/122123A1 |
Gender specific synthetic nutritional compositions comprising lycopene in concentrations reflecting those found in human milk produced by mothers of infants of the corresponding gender at the corresponding stage of lactation, and nutriti...
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WO/2019/122116A1 |
Synthetic nutritional compositions tailored for infants of specific ages comprising Lycopene in concentrations reflecting those found in human milk produced for infants of the same age, and nutritional systems comprising them.
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WO/2019/113645A1 |
The present invention relates to compounds with high chemical stability and methods for inhibiting the pathological activity of extracellular histones in a subject. In particular, the invention relates to compounds with high chemical sta...
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WO/2019/114647A1 |
A SUMO modification can occur at locus K288 of a NAD-reliant deacetylase SIRT3 in mitochondria and the activity thereof can be regulated; at the same time, a SUMO specific protease 1 (SENP1) can regulate the SUMO modification of SIRT3, t...
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WO/2019/113861A1 |
A ginkgo biloba extract medicinal raw material and a preparation method therefor, the ginkgo biloba extract medicinal raw material comprising a mixture formed by compounding a general lactone purification product and a general flavonoid ...
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WO/2019/109576A1 |
The present invention discloses a novel use of benzopyran compound, preparation of benzopyrone hamaudol and sec-O-Glucosylhamaudol, and an extract containing a rich benzopyran lactone, a preparation method, and a medical use thereof. The...
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WO/2019/113599A1 |
The presently disclosed subject matter is generally directed to novel nanobodies that can be used to neutralize bacterial toxins in a subject affected with harmful bacteria, such as bacteria associated with anthrax exposure and toxic sho...
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WO/2019/109346A1 |
Disclosed is a method for preparing a lycopene micro-capsule powder, wherein lycopene is fully mixed with an aqueous phase to obtain a lycopene emulsified liquid, and the emulsified liquid is then ground to a particle size less than 1 µ...
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WO/2019/106865A1 |
Provided are: an acyl novel steryl glucoside; and a method for producing an acyl steryl glucoside by using labyrinthula as a raw material. This acyl steryl glucoside is represented by structural formula (I), structural formula (II), or s...
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WO/2019/101700A1 |
A composition comprising at least one of oleuropein or curcumin can treat or prevent sarcopenia, reduce a loss of at least one of muscle quality or muscle mass, increase at least one of muscle quality or muscle mass, and/or improve recov...
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WO/2019/101924A1 |
The present invention relates to a von Willebrand factor composition for the prophylaxis and/or the treatment of a pathology mediated by angiogenesis.
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WO/2019/102353A1 |
The present disclosure relates to reversal agents, which specifically bind to anti-Factor XI and/or anti-Factor XIa antibodies, and reverse one or more anticoagulant effects of the anti- Factor XI and/or anti-Factor XIa antibodies, as we...
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WO/2019/103139A1 |
Provided are: an optically active trans-astaxanthin derivative or a salt thereof, which has excellent antioxidative activity, while having excellent water solubility and the like; and a composition which contains this derivative or a sal...
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WO/2019/103915A1 |
The present invention includes compositions and methods for treating an eye disease caused by oxidative damage in a subject in need thereof, the method comprising: identifying that the subject has a compromised blood-retinal barrier; and...
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WO/2019/102341A1 |
The object of the present invention is the use of Metadoxine as hepatoprotector against hepatic toxicity induced in patients undergoing treatment with Methotrexate, preferably in patients affected by rheumatoid arthritis. The invention f...
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WO/2019/099671A1 |
Disclosed are methods of reducing age-dependent lysosome impairment and/or treating an age related neurodegenerative disease, fibrotic disease, or rheumatological disease in a subject comprising administering to the subject a therapeutic...
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WO/2019/097187A1 |
The invention relates to compounds of the echinocandin family or a semi-synthetic derivative thereof or a salt thereof or an ester thereof, or an ester salt thereof, intended to be used as a cytoprotective drug, particularly as a drug fo...
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WO/2019/096114A1 |
An application of an oral pharmaceutical composition in manufacturing of a medication for regulating fibroblast growth and treating or preventing organ fibrosis. The pharmaceutical composition comprises a homogeneous mixture of an edible...
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WO/2019/094383A1 |
The present invention includes pharmaceutical composition comprising (2R,2R')- 3,3'-disulfanediyl bis(2-acetamidopropanamide)(diNACA) or D3-N-acetyl cysteine amide, or a physiologically acceptable salt thereof, having a deuterium enrichm...
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WO/2019/090976A1 |
A jerusalem artichoke capsule capable of lowering a blood pressure and a blood sugar and resisting against oxidation, and a preparation method therefor. The jerusalem artichoke capsule is prepared by using the following raw materials in ...
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WO/2019/086569A1 |
The present invention relates to alpha-1-microglobulin (A1M) for use in the protection of bone marrow cells in a subject.
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WO/2019/082128A1 |
The invention is directed to pharmaceutical compositions such as tablets that exhibit delayed release properties when administered as either whole or half tablets. The invention is also directed to delayed release tablets comprising defe...
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WO/2019/082339A1 |
Provided are: an anti-protein-toxin (anti-endotoxin and/or anti-enterotoxin) agent for livestock and fish, containing smectite as an active ingredient; and a method for preventing the action of a protein toxin on livestock through oral a...
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WO/2019/084460A1 |
The disclosure provides for methods and treatments of ischemic injury, reperfusion injury, stroke and myocardial infarctions by administering within minutes to hours an antibody or antibody fragment that bind to and inhibits the biologic...
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WO/2019/074404A1 |
The invention relates to the pharmaceutical industry and to medicine, and more particularly to complex polyionic infusion solutions that have a detoxifying effect as a result of antihypoxic, antioxidant and hepatoprotective properties. A...
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