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WO/2022/167688A1 |
The present invention concerns an in vivo method for introducing a naked mRNA molecule into the cytosol of a cell(s) in a subject, by the use of photochemical internalization, wherein the photosensitising agent is a sulphonated meso-tetr...
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WO/2022/169961A1 |
The invention relates to compounds, compositions, and methods of treating viral infection, especially SARS-CoV-2 infection.
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WO/2022/169103A1 |
The present invention relates to a nanoparticle thermotherapy apparatus based on an open magnetic particle image. The nanoparticle thermotherapy apparatus based on an open magnetic particle image, according to one embodiment of the prese...
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WO/2022/169019A1 |
The present invention relates to a novel compound for photodynamic cancer therapy, a composition comprising same, and a photodynamic cancer therapy method, and more specifically to: a novel photosensitizer compound which is based on NpIm...
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WO/2022/165045A1 |
Provided herein are methods for treating β-globinopathies, such as sickle cell disease and β-thalassemia, by inducing fetal hemoglobin expression and/or embryonic hemoglobin expression.
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WO/2022/162160A1 |
The invention relates to a bioconjugate comprising a photosensitizer unit, in particular a phthalocyanine unit, and an elastin-like polypeptide conjugated thereto, said elastin-like polypeptide containing at least one occurrence of a mon...
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WO/2022/162399A1 |
The invention describes particles having a polypeptide shell. The polypeptide shell comprises at least one immunomodulatory polypeptide. Particles may be ultrasound-responsive particles, providing the ability to administer particles tran...
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WO/2022/098801A9 |
The present invention provides novel compositions and methods for targeted delivery of therapeutics. In particular, the invention provides compositions comprising a plurality of carriers, such as microbubbles, wherein at least one active...
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WO/2022/163377A1 |
Provided is a photosensitizer which has a specific structure, and has higher sensitivity than existing photosensitizers when light irradiation causes a rapid change from hydrophilicity to hydrophobicity. The present invention pertains to...
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WO/2022/156419A1 |
The present invention relates to the technical field of pharmaceutical preparations, and in particular to a preparation of a Ce6-loaded lipid-coated calcium carbonate carrier, a preparation method therefor and an application thereof. Li/...
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WO/2022/156424A1 |
An amphiphilic molecular self-assembly nanodrug for tumor treatment, a preparation method therefor and a use thereof. Specifically disclosed is an amphiphilic compound, which is a conjugate of a hydrazine group-modified organic photother...
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WO/2022/151672A1 |
An endogenous photothermal therapy device system having micro-nano quantum dots and a preparation method therefor, relating to the field of micro-nano quantum dot photoelectric devices for minimally invasive medical treatment. According ...
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WO/2022/151911A1 |
A clamping sleeve. The clamping sleeve is a replaceable disposable medium transmission clamping sleeve and is suitable for operation in a radioactive isotope purification preparation/radioactive drug label synthesis process. The clamping...
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WO/2022/149934A1 |
The present invention relates to an antibody-polyethylene glycol-photosensitizer conjugate for anticancer immunotherapy of cancer cells in which a specific receptor is overexpressed. The conjugate improves the cancer cell targeting abili...
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WO/2022/143101A1 |
A drug-carrying microsphere-microneedle array for controllable drug administration, a preparation method therefor, and application thereof. The method comprises: preparing drug-carrying microspheres with a uniform particle size on the ba...
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WO/2022/137171A2 |
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WO/2022/140779A2 |
The current disclosure fulfills a need in the art by providing biomarkers that can be used in more effective diagnostic and treatment methods for GBM patients. Accordingly, aspects of the disclosure relate to a method for treating a subj...
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WO/2022/140339A1 |
This document relates to methods and materials for assessing and/or treating mammals (e.g., humans) having prostate cancer. For example, methods and materials for determining whether or not a prostate cancer is likely to respond to a par...
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WO/2022/137733A1 |
The present invention inactivates viruses included in a protein medicine such as an antibody medicine while suppressing the formation of an aggregate. The virus inactivation method comprises an irradiation step for irradiating a soluti...
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WO/2022/136936A1 |
A treatment support system based on the exposure of a user or surface to solar radiation, comprising a server (WS), a plurality of terminals and one or more satellite and/or meteorological atmospheric data sources interfaced with each ot...
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WO/2022/140082A2 |
This invention is directed to pharmaceutical compositions and methods for increasing immunogenicity in a cancer cell by contacting a cancer cell with epigenetic inhibitors to prompt the cancer cell's production of MHC-I-associated tumor ...
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WO/2022/134862A1 |
An organic conjugated polymer photo-thermal reagent for treating malignant melanoma, a nanoparticle, and a preparation method therefor and the use thereof. The structure of the organic conjugated polymer photo-thermal reagent for treatin...
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WO/2022/133304A1 |
Radionuclide brachytherapy sources and systems for applying beta radiation to a target area, for example for maintaining functioning drainage blebs or functioning drainage holes in the eye, e.g,, to reduce intraocular pressure (IOP) of a...
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WO/2022/127578A1 |
A magneto-responsive drug-loaded microneedle robot, a preparation method therefor and an application thereof. The magneto-responsive drug-loaded microneedle robot is prepared by using a layer-by-layer template filling and replication met...
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WO/2022/132623A1 |
Disclosed are compounds and compositions that bind to the La-related protein 1 (LARP1). LARP1 has roles as both a repressor of translation and stabilizer of mRNA transcripts, and therefore functions as a molecular switch in cancer biolog...
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WO/2022/131054A1 |
The present invention addresses the problem of providing: a method for decomposing a light-sensitive dye by means of energy rays which can reach deeper portions of the living body than near-infrared light to activate the light-sensitive ...
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WO/2022/124544A1 |
The present invention relates to a dendritic cell-mimicked nanostructure and a fabrication method therefor and, more specifically, to a nanostructure in which a shell including a cell membrane of dendritic cell-derived lipid molecules is...
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WO/2021/228867A9 |
The disclosure relates to methods for treating tumors. In particular, the disclosure relates to a method of treating a tumor by magnetic resonance image-guided radiation therapy in a subject in need thereof, said method comprising the st...
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WO/2022/120059A1 |
Exemplary embodiments of the present disclosure provides biomaterials, systems, and methods that utilize upconversion biomaterials to stimulate optogenetic cells in three-dimensional settings. Provided is a biomaterial including chromoph...
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WO/2022/117529A1 |
The invention concerns a particle and a composition comprising particles and their use in oncology. Specifically, the particles are porous, high-Z and carbon-free particles having internal pores, of longest dimension of at least 0.5 nm, ...
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WO/2022/116672A1 |
A tumor microenvironment response-type OFF-ON upconversion fluorescent probe, a preparation method therefor, and an application thereof. The preparation method is: synthesizing upconversion fluorescent nanoparticles UCNPs by means of hig...
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WO/2022/117564A1 |
The synthetic antiferromagnet disk-shaped particle comprises a first ferromagnetic layer, a second ferromagnetic layer and a non-magnetic interlayer arranged between the first and the second ferromagnetic layer, wherein each of the first...
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WO/2022/112944A1 |
The invention relates to a nanosystem for the diagnosis, image-guided treatment of tumors and monitoring of the tumor microenvironment. The nanosystem is a contrast agent comprising a polymer shell based on a hyaluronic acid nanogel, sup...
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WO/2022/114481A1 |
The present invention relates to a skin disease treatment device and a skin disease treatment system, which: have high efficacy in the treatment of not only bacteria but also fungi by inducing the generation of active oxygen in a photose...
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WO/2022/112206A1 |
The present invention relates to a composition comprising a liquid or a hydrogel comprising reactive oxygen and nitrogen species (RONS) and a STAT3 inhibitor, as well as to the use of said composition in the treatment of cancer.
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WO/2022/114829A1 |
The present invention relates to a beamforming device for a boron neutron capture therapy apparatus, and a boron neutron capture therapy apparatus comprising same, the beamforming device comprising: a shielding housing including a space ...
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WO/2022/115443A1 |
The present invention proves mitochondria-targeting nanofibers that are formed by assembly of small-molecule building blocks of amphiphilicity to improve photodynamic cancer therapy. Monomers derived from a pheophorbide a and quinolinium...
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WO/2022/107573A1 |
Provided is a near infrared photoimmunotherapy (NIR-PIT) targeting an immune checkpoint molecule expressed in a tumor. This NIR-PIT, which targets an immune checkpoint molecule, not only destroys cancer cells by light but also activates ...
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WO/2022/106787A1 |
The present disclosure relates to nanoparticles and the uses thereof in medicine, in particular for the treatment of tumours.
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WO/2022/100729A1 |
An adjuvant containing zinc aluminum risedronate, an immunogenic composition comprising the adjuvant and an immunogen, and uses of the adjuvant and the immunogenic composition.
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WO/2022/104097A2 |
Provided herein are MK2 activators, and compositions comprising an MK2 activator, for the treatment of a vascular disorder or an endothelial barrier disorder in a patient in need thereof, whereby the MK2 activator has a molecular weight ...
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WO/2022/100750A1 |
The present application relates to the technical field of medicines, and relates to a preparation available for photodynamic therapy or diagnosis. Particularly, provided is a preparation, and the preparation takes a compound represented ...
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WO/2022/104102A2 |
The present disclosure relates to materials and methods for treating or preventing corneal dysfunction or ocular surface disease.
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WO/2022/101666A1 |
A process for preparing a sterile polyclonal immunoglobulin composition includes pooling a plurality of plasma samples from donors exposed to an infectious agent or an antigenic component thereof to produce a pooled plasma composition, i...
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WO/2022/099088A1 |
Provided are methods, systems, and devices that pertain to siRNA-based nanobowl-mediated intervention for COVID-19.
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WO/2022/097473A1 |
Nanoparticles including at least one amphiphilic molecule and a polymer compound having a structural unit represented by formula (1). (In formula (1), Ar1 and Ar2 represent a trivalent aromatic hydrocarbon ring group or a trivalent aro...
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WO/2022/096291A1 |
The invention relates to nanoparticles and/or aggregates of nanoparticles and a composition comprising nanoparticles and/or aggregates of nanoparticles and their use in oncology. Specifically, the nanoparticles and/or aggregates of nanop...
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WO/2022/082816A1 |
Disclosed is use of red blood cells in the preparation of a photothermal conversion material, and further disclosed is use of red blood cells in the preparation of a tumor photothermal therapy formulation. Red blood cells have a good hea...
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WO/2022/086907A1 |
The present disclosure relates to a method of treating a Pseudomonas aeruginosa infection, comprising: administering an effective amount of thermally activated clay, wherein the thermally activated clay absorbs pyocyanin and siderophore ...
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WO/2022/087110A1 |
Provided herein are methods and compositions related to cryo-shocked cells useful as therapeutic agents. The cryo-shocked cells may be formulated as a vaccine. Disclosed are methods of preparing dead cryo-shocked cells. Disclosed are als...
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